ENSGALG00000039942


Gallus gallus

Features
Gene ID: ENSGALG00000039942
  
Biological name :CTBP1
  
Synonyms : CTBP1 / C-terminal-binding protein 1
  
Possible biological names infered from orthology : O88712 / Q13363
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 85212799
Gene end: 85346817
  
Corresponding Affymetrix probe sets: Gga.3495.1.S1_s_at (Chicken Array)   GgaAffx.12741.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048555
NCBI entrez gene - 422904     See in Manteia.
RefSeq - NM_001012890
RefSeq Peptide - NP_001012908
swissprot - Q5ZIZ6
Ensembl - ENSGALG00000039942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:136929ENSDARG00000019213Danio rerio
 CTBP1ENSG00000159692Homo sapiens
 Ctbp1ENSMUSG00000037373Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTBP2 / C-terminal binding protein 2 / P56545* / P56546*ENSGALG0000000973881
CTBPLENSGALG0000000764280
PHGDH / phosphoglycerate dehydrogenase / O43175* / Q61753* / D-3-phosphoglycerate dehydrogenase *ENSGALG0000000298826


Protein motifs (from Interpro)
Interpro ID Name
 IPR006139  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
 IPR006140  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
 IPR016040  NAD(P)-binding domain
 IPR029752  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
 IPR029753  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0031065 positive regulation of histone deacetylation IEA
 biological_processGO:0035067 negative regulation of histone acetylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0050872 white fat cell differentiation IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0090241 negative regulation of histone H4 acetylation IEA
 biological_processGO:1903758 negative regulation of transcription from RNA polymerase II promoter by histone modification IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016618 hydroxypyruvate reductase activity IBA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030267 glyoxylate reductase (NADP) activity IBA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex
SUMOylation of transcription cofactors
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000220 APC / APC, WNT signaling pathway regulator / P25054*  / complex
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000008883 TCF7L2 / transcription factor 7 like 2 / Q924A0* / Q9NQB0* / transcription factor 7 like 2, T cell specific, HMG box*  / complex / reaction
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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