ENSMUSG00000037373


Mus musculus

Features
Gene ID: ENSMUSG00000037373
  
Biological name :Ctbp1
  
Synonyms : Ctbp1 / C-terminal-binding protein 1 / O88712
  
Possible biological names infered from orthology : Q13363
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B1
Gene start: 33247723
Gene end: 33274994
  
Corresponding Affymetrix probe sets: 10529273 (MoGene1.0st)   10338138 (MoGene1.0st)   10338730 (MoGene1.0st)   10338815 (MoGene1.0st)   10339439 (MoGene1.0st)   10339589 (MoGene1.0st)   10340460 (MoGene1.0st)   10340495 (MoGene1.0st)   10340571 (MoGene1.0st)   10341048 (MoGene1.0st)   10341253 (MoGene1.0st)   10342696 (MoGene1.0st)   10338267 (MoGene1.0st)   10338672 (MoGene1.0st)   10338831 (MoGene1.0st)   10338848 (MoGene1.0st)   10339051 (MoGene1.0st)   10339131 (MoGene1.0st)   10339187 (MoGene1.0st)   10339363 (MoGene1.0st)   10339979 (MoGene1.0st)   10340942 (MoGene1.0st)   10341620 (MoGene1.0st)   10341669 (MoGene1.0st)   10341884 (MoGene1.0st)   10341898 (MoGene1.0st)   10342919 (MoGene1.0st)   10343313 (MoGene1.0st)   10343573 (MoGene1.0st)   10344097 (MoGene1.0st)   10344467 (MoGene1.0st)   1415702_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143877
Ensembl peptide - ENSMUSP00000144672
Ensembl peptide - ENSMUSP00000144596
Ensembl peptide - ENSMUSP00000144554
Ensembl peptide - ENSMUSP00000144303
Ensembl peptide - ENSMUSP00000144251
Ensembl peptide - ENSMUSP00000144029
Ensembl peptide - ENSMUSP00000144024
Ensembl peptide - ENSMUSP00000078682
NCBI entrez gene - 13016     See in Manteia.
MGI - MGI:1201685
RefSeq - NM_013502
RefSeq - NM_001310535
RefSeq - NM_001198859
RefSeq - NM_001198860
RefSeq - NM_001198861
RefSeq Peptide - NP_038530
RefSeq Peptide - NP_001185788
RefSeq Peptide - NP_001185789
RefSeq Peptide - NP_001185790
RefSeq Peptide - NP_001297464
swissprot - O88712
swissprot - A0A0J9YVC3
swissprot - A0A0J9YUR5
swissprot - A0A0J9YUM4
swissprot - A0A0J9YU66
swissprot - A0A0J9YU62
swissprot - A0A0J9YTW3
swissprot - A0A0J9YVI3
Ensembl - ENSMUSG00000037373
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:136929ENSDARG00000019213Danio rerio
 CTBP1ENSGALG00000039942Gallus gallus
 CTBP1ENSG00000159692Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctbp2 / P56546 / C-terminal-binding protein 2 ENSMUSG0000003097078
Phgdh / Q61753 / D-3-phosphoglycerate dehydrogenase / O43175* / phosphoglycerate dehydrogenase*ENSMUSG0000005339825


Protein motifs (from Interpro)
Interpro ID Name
 IPR006139  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
 IPR006140  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
 IPR029752  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
 IPR029753  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031065 positive regulation of histone deacetylation IEA
 biological_processGO:0035067 negative regulation of histone acetylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0050872 white fat cell differentiation IDA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0090241 negative regulation of histone H4 acetylation IEA
 biological_processGO:1903758 negative regulation of transcription from RNA polymerase II promoter by histone modification IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016618 hydroxypyruvate reductase activity IBA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030267 glyoxylate reductase (NADP) activity IBA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0051287 NAD binding ISS
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex
SUMOylation of transcription cofactors
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1+,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctbp1tm1Sor/Ctbp1+,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Ctbp1tm1Sor/Ctbp1+,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1+,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Ctbp1tm1Sor/Ctbp1+,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2Gt(ROSA61)Sor
Genetic Background: involves: 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction






 

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