ENSMUSG00000030970


Mus musculus

Features
Gene ID: ENSMUSG00000030970
  
Biological name :Ctbp2
  
Synonyms : Ctbp2 / C-terminal-binding protein 2 / P56546
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 132987563
Gene end: 133124354
  
Corresponding Affymetrix probe sets: 10568605 (MoGene1.0st)   1422887_a_at (Mouse Genome 430 2.0 Array)   1434705_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127701
Ensembl peptide - ENSMUSP00000133269
Ensembl peptide - ENSMUSP00000132892
Ensembl peptide - ENSMUSP00000132558
Ensembl peptide - ENSMUSP00000132399
Ensembl peptide - ENSMUSP00000130727
Ensembl peptide - ENSMUSP00000130294
Ensembl peptide - ENSMUSP00000129590
Ensembl peptide - ENSMUSP00000129312
Ensembl peptide - ENSMUSP00000128944
Ensembl peptide - ENSMUSP00000033269
Ensembl peptide - ENSMUSP00000126126
Ensembl peptide - ENSMUSP00000127448
NCBI entrez gene - 13017     See in Manteia.
MGI - MGI:1201686
RefSeq - XM_006507315
RefSeq - XM_006507314
RefSeq - XM_006507312
RefSeq - XM_006507311
RefSeq - NM_001170744
RefSeq - XM_006507309
RefSeq - XM_006507308
RefSeq - NM_009980
RefSeq - XM_006507310
RefSeq Peptide - NP_001164215
RefSeq Peptide - NP_001334552
RefSeq Peptide - NP_034110
swissprot - E9Q4S8
swissprot - E9Q815
swissprot - P56546
swissprot - Q3UGL5
swissprot - Q91YZ2
swissprot - E9PX05
swissprot - E9PZG2
swissprot - E9Q0T4
swissprot - E9Q0V8
swissprot - E9Q123
swissprot - E9PWQ9
swissprot - E9QA96
Ensembl - ENSMUSG00000030970
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctbp2aENSDARG00000044062Danio rerio
 CTBP2ENSGALG00000009738Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctbp1 / O88712 / C-terminal-binding protein 1 / Q13363*ENSMUSG0000003737335
Phgdh / Q61753 / D-3-phosphoglycerate dehydrogenase / O43175* / phosphoglycerate dehydrogenase*ENSMUSG0000005339812


Protein motifs (from Interpro)
Interpro ID Name
 IPR006139  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
 IPR006140  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
 IPR029753  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035563 positive regulation of chromatin binding IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048386 positive regulation of retinoic acid receptor signaling pathway ISO
 biological_processGO:0050872 white fat cell differentiation IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0097470 ribbon synapse IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003713 transcription coactivator activity IGI
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016618 hydroxypyruvate reductase activity IBA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0030267 glyoxylate reductase (NADP) activity IBA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0042974 retinoic acid receptor binding IPI
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1+,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1+,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1+,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1+,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2Gt(ROSA61)Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1+,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Ctbp1tm1Sor/Ctbp1tm1Sor,Ctbp2Gt(ROSA61)Sor/Ctbp2Gt(ROSA61)Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
Show

Allelic Composition: Nkx2-9tm1Jlck/Nkx2-9tm1Jlck
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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