ENSDARG00000044062


Danio rerio

Features
Gene ID: ENSDARG00000044062
  
Biological name :ctbp2a
  
Synonyms : ctbp2a / C-terminal binding protein 2a
  
Possible biological names infered from orthology : CTBP2 / C-terminal binding protein 2 / P56545 / P56546
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 8595588
Gene end: 8727748
  
Corresponding Affymetrix probe sets: Dr.2550.1.S1_s_at (Zebrafish Array)   NM_131715_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000049235
Ensembl peptide - ENSDARP00000123819
Ensembl peptide - ENSDARP00000123977
Ensembl peptide - ENSDARP00000124033
Ensembl peptide - ENSDARP00000124211
Ensembl peptide - ENSDARP00000145330
Ensembl peptide - ENSDARP00000148839
Ensembl peptide - ENSDARP00000006342
Ensembl peptide - ENSDARP00000017286
Ensembl peptide - ENSDARP00000123768
Ensembl peptide - ENSDARP00000124257
Ensembl peptide - ENSDARP00000124329
Ensembl peptide - ENSDARP00000124471
Ensembl peptide - ENSDARP00000124751
Ensembl peptide - ENSDARP00000124822
Ensembl peptide - ENSDARP00000134141
NCBI entrez gene - 65230     See in Manteia.
RefSeq - NM_001195491
RefSeq - NM_131715
RefSeq Peptide - NP_001182420
RefSeq Peptide - NP_571790
swissprot - F1QMW3
swissprot - F1RA12
swissprot - F8W377
swissprot - F8W3Q3
swissprot - F8W3U1
swissprot - F8W438
swissprot - F8W4E9
swissprot - F8W509
swissprot - F8W571
swissprot - Q6NZ25
swissprot - Q7SZN5
swissprot - Q9DEG6
ZFIN ID - ZDB-GENE-010130-2
Ensembl - ENSDARG00000044062
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTBP2ENSGALG00000009738Gallus gallus
 CTBP2ENSG00000175029Homo sapiens
 Ctbp2ENSMUSG00000030970Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zgc:136929 / CTBP1* / O88712* / Q13363* / C-terminal binding protein 1*ENSDARG0000001921349
ctbp1 / C-terminal binding protein 1ENSDARG0000005700746
phgdh / phosphoglycerate dehydrogenase / O43175* / Q61753* / D-3-phosphoglycerate dehydrogenase *ENSDARG0000000187315


Protein motifs (from Interpro)
Interpro ID Name
 IPR006139  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
 IPR006140  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016040  NAD(P)-binding domain
 IPR029753  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0014013 regulation of gliogenesis IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045634 regulation of melanocyte differentiation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060386 synapse assembly involved in innervation IGI
 biological_processGO:0070073 clustering of voltage-gated calcium channels IGI
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016618 hydroxypyruvate reductase activity IBA
 molecular_functionGO:0030267 glyoxylate reductase (NADP) activity IBA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye movement quality , abnormal
Show

 ZFA:0000152 retina retina apoptotic , abnormal
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 ZFA:0001114 head head melanocyte increased amount , abnormal
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 ZFA:0001115 trunk trunk glial cell projection mislocalised , abnormal
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 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer decreased amount , abnormal
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 ZFA:0001330 retinal outer plexiform layer retinal outer plexiform layer absent , abnormal
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 ZFA:0009091 melanocyte melanocyte increased amount , abnormal
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 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell cytoskeleton of presynaptic active zone decreased length , abnormal
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 ZFA:0009318 retinal bipolar neuron retinal bipolar neuron cytoskeleton of presynaptic active zone morphology , abnormal
Show

 ZFA:0009321 rod bipolar cell rod bipolar cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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