ENSG00000175029


Homo sapiens

Features
Gene ID: ENSG00000175029
  
Biological name :CTBP2
  
Synonyms : CTBP2 / C-terminal binding protein 2 / P56545
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q26.13
Gene start: 124984317
Gene end: 125161170
  
Corresponding Affymetrix probe sets: 201218_at (Human Genome U133 Plus 2.0 Array)   201219_at (Human Genome U133 Plus 2.0 Array)   201220_x_at (Human Genome U133 Plus 2.0 Array)   210554_s_at (Human Genome U133 Plus 2.0 Array)   210835_s_at (Human Genome U133 Plus 2.0 Array)   215377_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436285
Ensembl peptide - ENSP00000434630
Ensembl peptide - ENSP00000481909
Ensembl peptide - ENSP00000311825
Ensembl peptide - ENSP00000338615
Ensembl peptide - ENSP00000357816
Ensembl peptide - ENSP00000410474
Ensembl peptide - ENSP00000434424
NCBI entrez gene - 1488     See in Manteia.
OMIM - 602619
RefSeq - XM_017015757
RefSeq - NM_001083914
RefSeq - NM_001290214
RefSeq - NM_001290215
RefSeq - NM_001321012
RefSeq - NM_001321013
RefSeq - NM_001321014
RefSeq - NM_001329
RefSeq - NM_022802
RefSeq - XM_005269571
RefSeq - XM_005269572
RefSeq - XM_006717642
RefSeq - XM_011539349
RefSeq - XM_011539351
RefSeq - XM_011539353
RefSeq - XM_011539354
RefSeq - XM_011539355
RefSeq - XM_011539357
RefSeq - XM_011539358
RefSeq - XM_017015756
RefSeq - XM_005269561
RefSeq - XM_005269564
RefSeq - XM_005269567
RefSeq - XM_005269568
RefSeq - XM_005269569
RefSeq Peptide - NP_001077383
RefSeq Peptide - NP_001277143
RefSeq Peptide - NP_001277144
RefSeq Peptide - NP_001307941
RefSeq Peptide - NP_001307942
RefSeq Peptide - NP_001307943
RefSeq Peptide - NP_001320
RefSeq Peptide - NP_073713
swissprot - P56545
swissprot - Q5SQP8
swissprot - A0A087WYL1
Ensembl - ENSG00000175029
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctbp2aENSDARG00000044062Danio rerio
 CTBP2ENSGALG00000009738Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTBP1 / Q13363 / C-terminal binding protein 1ENSG0000015969235
PHGDH / O43175 / phosphoglycerate dehydrogenaseENSG0000009262112


Protein motifs (from Interpro)
Interpro ID Name
 IPR006139  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
 IPR006140  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
 IPR029753  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019079 viral genome replication TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048386 positive regulation of retinoic acid receptor signaling pathway IMP
 biological_processGO:0050872 white fat cell differentiation ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0017053 transcriptional repressor complex ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016618 hydroxypyruvate reductase activity IBA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030267 glyoxylate reductase (NADP) activity IBA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Repression of WNT target genes
TCF7L2 mutants dont bind CTBP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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