ENSGALG00000000220


Gallus gallus

Features
Gene ID: ENSGALG00000000220
  
Biological name :APC
  
Synonyms : APC / APC, WNT signaling pathway regulator
  
Possible biological names infered from orthology : P25054
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 46027195
Gene end: 46082742
  
Corresponding Affymetrix probe sets: Gga.10382.1.S1_s_at (Chicken Array)   GgaAffx.137.1.S1_at (Chicken Array)   GgaAffx.20763.1.S1_at (Chicken Array)   GgaAffx.25327.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000000295
Ensembl peptide - ENSGALP00000057743
Ensembl peptide - ENSGALP00000053288
Ensembl peptide - ENSGALP00000050374
NCBI entrez gene - 415607     See in Manteia.
RefSeq - XM_015280450
RefSeq - XM_015280445
RefSeq - XM_015280446
RefSeq - XM_015280448
RefSeq - XM_015280449
RefSeq - XM_001233410
RefSeq - XM_004949280
RefSeq - XM_004949281
RefSeq - XM_004949282
RefSeq - XM_004949283
RefSeq - XM_004949285
RefSeq - XM_004949286
RefSeq - XM_015280443
RefSeq - XM_015280444
swissprot - E1BZS9
swissprot - A0A1D5PXP6
swissprot - A0A1D5PKD1
swissprot - A0A1D5PC88
Ensembl - ENSGALG00000000220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apcENSDARG00000058868Danio rerio
 APCENSG00000134982Homo sapiens
 ApcENSMUSG00000005871Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
APC2 / adenomatous polyposis coli protein 2 / O95996* / APC2, WNT signaling pathway regulator*ENSGALG0000004215333


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR009223  Adenomatous polyposis coli protein repeat
 IPR009224  SAMP
 IPR009232  EB-1 binding
 IPR009234  Adenomatous polyposis coli protein basic domain
 IPR009240  Adenomatous polyposis coli protein, 15 residue repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR026818  Adenomatous polyposis coli (APC) family
 IPR026831  Adenomatous polyposis coli protein
 IPR026836  Adenomatous polyposis coli
 IPR032038  Adenomatous polyposis coli, N-terminal dimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007026 negative regulation of microtubule depolymerization IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031274 positive regulation of pseudopodium assembly IEA
 biological_processGO:0032886 regulation of microtubule-based process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051988 regulation of attachment of spindle microtubules to kinetochore IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1904781 positive regulation of protein localization to centrosome IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0016342 catenin complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030877 beta-catenin destruction complex IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0019887 protein kinase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045295 gamma-catenin binding IEA
 molecular_functionGO:0051010 microtubule plus-end binding IEA
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Deactivation of the beta-catenin transactivating complex
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000031474 ZRANB1 / zinc finger RANBP2-type containing 1 / Q7M760* / Q9UGI0* / zinc finger, RAN-binding domain containing 1*  / complex / reaction
 ENSGALG00000039942 CTBP1 / C-terminal-binding protein 1 / O88712* / Q13363*  / complex
 ENSGALG00000010638 CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*  / reaction






 

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