ENSDARG00000058868


Danio rerio

Features
Gene ID: ENSDARG00000058868
  
Biological name :apc
  
Synonyms : adenomatous polyposis coli / apc
  
Possible biological names infered from orthology : APC, WNT signaling pathway regulator / P25054
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 1849874
Gene end: 1893095
  
Corresponding Affymetrix probe sets: Dr.19924.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000139275
Ensembl peptide - ENSDARP00000123835
NCBI entrez gene - 386762     See in Manteia.
RefSeq - NM_001143840
RefSeq - XM_005155523
RefSeq - XM_017357938
RefSeq Peptide - NP_001137312
swissprot - F8W4Z3
swissprot - A0A0R4IWH7
ZFIN ID - ZDB-GENE-031112-7
Ensembl - ENSDARG00000058868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APCENSGALG00000000220Gallus gallus
 APCENSG00000134982Homo sapiens
 ApcENSMUSG00000005871Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
apc2 / adenomatosis polyposis coli 2 / O95996* / APC2, WNT signaling pathway regulator*ENSDARG0000006300728


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR009223  Adenomatous polyposis coli protein repeat
 IPR009224  SAMP
 IPR009232  EB-1 binding
 IPR009234  Adenomatous polyposis coli protein basic domain
 IPR009240  Adenomatous polyposis coli protein, 15 residue repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR026818  Adenomatous polyposis coli (APC) family
 IPR026831  Adenomatous polyposis coli protein
 IPR026836  Adenomatous polyposis coli
 IPR027397  Catenin binding domain superfamily
 IPR032038  Adenomatous polyposis coli, N-terminal dimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001754 eye photoreceptor cell differentiation IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0003157 endocardium development IMP
 biological_processGO:0003170 heart valve development IMP
 biological_processGO:0003306 Wnt signaling pathway involved in heart development IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007026 negative regulation of microtubule depolymerization IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0022006 zona limitans intrathalamica formation IMP
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0030855 epithelial cell differentiation IMP
 biological_processGO:0030917 midbrain-hindbrain boundary development IMP
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0033334 fin morphogenesis IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035118 embryonic pectoral fin morphogenesis IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0044030 regulation of DNA methylation IMP
 biological_processGO:0048384 retinoic acid receptor signaling pathway IGI
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0048920 posterior lateral line neuromast primordium migration IMP
 biological_processGO:0055001 muscle cell development IGI
 biological_processGO:0055123 digestive system development IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0061031 endodermal digestive tract morphogenesis IMP
 biological_processGO:0061380 superior colliculus development IMP
 biological_processGO:0070365 hepatocyte differentiation IMP
 biological_processGO:0071599 otic vesicle development IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0090244 Wnt signaling pathway involved in somitogenesis IGI
 biological_processGO:1900052 regulation of retinoic acid biosynthetic process IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000006 ball ball deformed , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle mislocalised radially , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta blood circulation decreased process quality , abnormal
dorsal aorta blood decreased fluid flow , abnormal
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 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer disorganized , abnormal
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 ZFA:0000040 median fin fold median fin fold laminin complex increased amount , abnormal
median fin fold epithelial cell proliferation decreased occurrence , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
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 ZFA:0000051 otic vesicle otic vesicle increased size , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000056 pharynx pharynx immature , abnormal
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 ZFA:0000059 postoptic commissure postoptic commissure morphology , abnormal
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 ZFA:0000084 yolk yolk increased size , abnormal
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 ZFA:0000100 cerebellum cerebellum morphology , abnormal
cerebellum disorganized , abnormal
cerebellum dorsal region curved , abnormal
cerebellum dorsal region increased size , abnormal
cerebellum ventral region decreased thickness , abnormal
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 ZFA:0000101 diencephalon diencephalon decreased size , abnormal
diencephalon flattened , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000109 forebrain forebrain wholly dorsalized , abnormal
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 ZFA:0000112 gut gut deformed , abnormal
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 ZFA:0000114 heart heart decreased contractility , abnormal
heart quality , abnormal
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 ZFA:0000123 liver liver increased size , abnormal
liver has extra parts of type hepatocyte , abnormal
liver apoptotic , abnormal
liver neoplastic, spontaneous , abnormal
liver adenoma present , abnormal
liver aplastic , abnormal
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 ZFA:0000124 liver primordium liver primordium increased size , abnormal
liver primordium aplastic , abnormal
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 ZFA:0000137 optic stalk optic stalk morphology , abnormal
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 ZFA:0000140 pancreas pancreas decreased size , abnormal
pancreas aplastic , abnormal
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 ZFA:0000152 retina retina morphology , abnormal
retina immature , abnormal
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 ZFA:0000155 somite somite decreased amount , abnormal
somite morphology , abnormal
somite flattened , abnormal
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 ZFA:0000159 tectal ventricle tectal ventricle collapsed , abnormal
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 ZFA:0000243 neuromast neuromast has extra parts of type neuromast hair cell , abnormal
neuromast mitotic cell cycle increased rate , abnormal
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 ZFA:0000320 caudal commissure caudal commissure morphology , abnormal
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 ZFA:0000435 cranial nerve II cranial nerve II malformed , abnormal
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 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
optic tectum flattened , abnormal
optic tectum apoptotic , abnormal
optic tectum opaque , abnormal
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 ZFA:0001056 myotome myotome slow muscle cell hypertrophic , abnormal
myotome slow muscle cell hyperplastic , abnormal
myotome fast muscle cell disorganized , abnormal
myotome fast muscle cell hypertrophic , abnormal
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 ZFA:0001069 ventral fin fold ventral fin fold morphology , abnormal
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 ZFA:0001076 intestinal bulb intestinal bulb hypoplastic , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism curved , abnormal
whole organism dead , abnormal
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 ZFA:0001108 anterior commissure anterior commissure morphology , abnormal
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 ZFA:0001114 head head shape , abnormal
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 ZFA:0001120 neuroectoderm neuroectoderm anterior region decreased size , abnormal
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 ZFA:0001153 tooth placode tooth placode agenesis , abnormal
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 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium spatial pattern , abnormal
posterior lateral line primordium increased distribution , abnormal
posterior lateral line primordium decreased distribution , abnormal
posterior lateral line primordium morphology , abnormal
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 ZFA:0001161 pectoral fin pectoral fin absent , abnormal
pectoral fin decreased length , abnormal
pectoral fin ruffled , abnormal
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 ZFA:0001180 epidermal basal stratum epidermal basal stratum decreased height , abnormal
epidermal basal stratum epithelial cell morphogenesis decreased process quality , abnormal
epidermal basal stratum canonical Wnt signaling pathway increased process quality , abnormal
epidermal basal stratum ecto-epithelial cell elongated , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton immature , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal obstructed , abnormal
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 ZFA:0001318 cardiac jelly cardiac jelly increased volume , abnormal
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 ZFA:0001320 endocardium endocardium hyperplastic , abnormal
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 ZFA:0001338 intestine intestine neoplastic, spontaneous , abnormal
intestine adenoma present , abnormal
intestine adenomatous polyp present , abnormal
intestine morphology , abnormal
intestine lacks all parts of type intestinal villus , abnormal
intestine lacks all parts of type columnar/cuboidal epithelial cell , abnormal
intestine immature , abnormal
intestine poorly differentiated , abnormal
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 ZFA:0001344 zona limitans intrathalamica zona limitans intrathalamica morphology , abnormal
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 ZFA:0001383 fin bud fin bud immature , abnormal
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 ZFA:0001390 pancreatic bud pancreatic bud decreased size , abnormal
pancreatic bud aplastic , abnormal
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 ZFA:0001616 atrioventricular canal endocardium atrioventricular canal endocardium decreased amount , abnormal
atrioventricular canal endocardium fused with atrioventricular canal endocardium , abnormal
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 ZFA:0001625 optic nerve head optic nerve head decreased thickness , abnormal
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 ZFA:0001718 presumptive atrium heart tube presumptive atrium heart tube mislocalised radially , abnormal
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 ZFA:0005064 atrioventricular valve atrioventricular valve malformed , abnormal
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 ZFA:0005124 intestinal epithelium intestinal epithelium aplastic , abnormal
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 ZFA:0009111 hepatocyte hepatocyte increased amount , abnormal
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 ZFA:0009115 skeletal muscle cell skeletal muscle cell hypertrophic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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