| MP:0000022 | abnormal ear shape | "malformation of the pattern of the external ear" [J:65038] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
|
| MP:0000087 | absent mandible | "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: ApcMin/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1.1Tno/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * BALB/cJ * C57BL/6
|
| MP:0000116 | abnormal tooth development | "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
|
| MP:0000124 | absent teeth | "missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
|
| MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000158 | absent sternum | "missing long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62577] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000162 | lordosis | "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022] |
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Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J
|
| MP:0000164 | abnormal cartilage development | "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000166 | abnormal chondrocyte morphology | "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Apctm1Tno/Apc+,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(Car1-cre)5Flt/0
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm2Rak/Apc+,Tg(Car1-cre)5Flt/0
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
|
| MP:0000324 | increased mast cell number | "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apctm1Kk/Apctm1Kk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
|
| MP:0000350 | abnormal cell proliferation | "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm2.1Rak/Apc+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
|
| MP:0000351 | increased cell proliferation | "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/?,Tg(Il17f-cre)1Awai/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
Allelic Composition: Apctm1.1Alew/Apc+
Genetic Background: B6.129-Apctm1.1Alew
|
| MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
|
| MP:0000417 | short hair | "reduced average length of the hairs" [J:64948] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
|
| MP:0000422 | delayed hair appearance | "late onset of the first appearance of the fur" [J:17792] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0000428 | abnormal craniofacial morphology | "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000438 | abnormal skull morphology | "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000458 | abnormal mandible morphology | "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000462 | abnormal digestive system morphology | "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm1Hsa/Apctm1Hsa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000465 | gastrointestinal hemorrhage | "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1.1Tno/Apc+
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0000474 | abnormal foregut morphology | "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
|
| MP:0000477 | abnormal intestine morphology | "malformation of the digestive tube passing from the stomach to the anus" [J:48968] |
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Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1Mmt/Apc+,Ptgs2tm1Jed/Ptgs2+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Apctm1Mmt/Apc+,Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J
|
| MP:0000488 | abnormal intestinal epithelium morphology | "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2r+
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: ApcMin/Apc+,Elp3tm1.1Tac/Elp3tm1.1Tac,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
Allelic Composition: Apctm1Tno/Apctm1Tno,Elp3tm1.1Tac/Elp3tm1.1Tac,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
|
| MP:0000490 | abnormal crypts of Lieberkuhn morphology | "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm1Hsa/Apctm1Hsa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/ApcMin,Rr27tm1Rohl/Rr27+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2r+
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic Background: involves: C57BL/6J
|
| MP:0000493 | rectal prolapse | "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm1Cip/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1Tno/Apc+,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(Car1-cre)5Flt/0
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
| MP:0000495 | abnormal colon morphology | "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0000496 | abnormal small intestine morphology | "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Phox2a/Inppl1tm1Ssch/Inppl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt
Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
|
| MP:0000511 | abnormal intestinal mucosa morphology | "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1Kk/Apctm1Kk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
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| MP:0000540 | abnormal urinary bladder epithelium morphology | "malformation of the epithelial layer of the urinary bladder" [MGI:tc] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129X1/SvJ * FVB/N
Allelic Composition: Apctm1Tno/Apctm1Tno,Gsk3atm1Jrw/Gsk3atm1Jrw,Gsk3btm2Jrw/Gsk3btm2Jrw
Genetic Background: involves: 129 * C57BL/6 * CBA
Allelic Composition: Apctm1Tno/Apctm1Tno,Ptentm1Hwu/Ptentm1Hwu,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0000550 | abnormal forelimb morphology | "malformation of the entire anterior extremities" [MGI:tc] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0000556 | abnormal hindlimb morphology | "malformation of the entire posterior extremities" [MGI:tc] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0000585 | kinked tail | "a sharp bend or zig-zag in the tail" [J:61295] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(CDX2-cre*)189Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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| MP:0000592 | short tail | "reduced length of tail compared to control " [J:55583] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(CDX2-cre*)189Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
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| MP:0000619 | salivary gland epithelial hyperplasia | "increased cell number in the epithelium of the salivary gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0000628 | abnormal mammary gland development | "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
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| MP:0000630 | mammary gland hyperplasia | "increased size of mammary gland due to increased cell number" [J:63229] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: B6(AKR)-ApcMin
|
| MP:0000639 | abnormal adrenal gland morphology | "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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| MP:0000659 | prostate gland hyperplasia | "increased cell number in the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2
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| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
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| MP:0000703 | abnormal thymus morphology | "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0000706 | small thymus | "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167] |
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Allelic Composition: Apctm1Kk/Apctm1Kk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0000715 | decreased thymocyte number | "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
Allelic Composition: ApcMin/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1.1Tno/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * BALB/cJ * C57BL/6
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| MP:0000925 | abnormal floor plate morphology | "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
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| MP:0000934 | abnormal telencephalon development | "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840] |
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Allelic Composition: Ctnnb1tm1.2Wvv/Ctnnb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001130 | abnormal ovarian folliculogenesis | "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
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| MP:0001131 | abnormal ovarian follicles | "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
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| MP:0001132 | absent mature ovarian follicles | "failure of ovarian follicle differentiation" [J:35782] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
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| MP:0001134 | absent corpora lutea | "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
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| MP:0001140 | abnormal vaginal epithelium | "malformation of the epithelial layer of the vagina" [J:54637, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
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| MP:0001192 | scaly skin | "skin covered with shedding scales or flakes" [J:65146] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0001208 | blistering | "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001210 | thick skin ridges | "long raised strips of skin, usually aligned to the proximal-distal axis" [J:51296] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0001211 | wrinkled skin | "irregular folds and/or indentations on the skin" [J:19212] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0001247 | dermal cysts | "abnormal membranous sacs appearing in the dermis" [J:53379] |
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1.1Rsmi/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
|
| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
Allelic Composition: Apctm1Tno/Apc+,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(Car1-cre)5Flt/0
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR
|
| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0001272 | increased metastatic potential | |
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Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
Allelic Composition: Aestm1.1Mmt/Aestm1.1Mmt,Apctm1Mmt/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA * SJL
Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm2Rak/Apc+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL
Allelic Composition: ApcMin/Apc+,Hltftm1.1Hdin/Hltftm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N
|
| MP:0001282 | short vibrissae | "decreased length of the vibrissae" [J:30249] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0001344 | blepharoptosis | "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0001382 | abnormal nursing | "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm2.1Rak/Apc+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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| MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
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Allelic Composition: Apctm2.1Alew/Apctm2.1Alew
Genetic Background: B6.129-Apctm2.1Alew
Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Apctm2Cip/Apc+,Cdkn2atm1Cjs/Cdkn2atm1Cjs,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0001548 | hyperlipidemia | "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Apctm2Tno/Apc+
Genetic Background: involves: C57BL/6J
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| MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: C57BL/6J-ApcMin
Allelic Composition: Apctm2Tno/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm2Rak/Apc+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL
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| MP:0001554 | increased circulating free fatty acid level | "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: C57BL/6J-ApcMin
Allelic Composition: Apctm2Tno/Apc+
Genetic Background: involves: C57BL/6J
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| MP:0001570 | abnormal circulating enzyme level | "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1Cip/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm2.1Rak/Apc+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm1.1Tno/Apc+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
Allelic Composition: Apctm1Tno/Apc+,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm1Tno/Apc+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: ApcMin/Apc+,Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Apctm1.1Rsmi/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Apctm1.1Tyj/Apc+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Apctm2Rak/Apc+,Tg(Car1-cre)5Flt/0
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm1.1Alew/Apc+
Genetic Background: B6.129-Apctm1.1Alew
Allelic Composition: Apctm2.1Alew/Apc+
Genetic Background: B6.129-Apctm2.1Alew
Allelic Composition: ApcMin/Apc+
Genetic Background: B6(AKR)-ApcMin
Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J
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| MP:0001654 | hepatic necrosis | "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0001661 | extended life span | "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Inpp5em1Tc/Inpp5em1Tc
Genetic Background: involves: C57BL/6J * FVB/N
Allelic Composition: ApcMin/Apc+
Genetic Background: (MA/MyJ x C57BL/6J-ApcMin)F1
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| MP:0001663 | abnormal digestive system physiology | "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tmprss6m2Btlr/Tmprss6m2Btlr
Genetic Background: C57BL/6J-Tmprss6m2Btlr
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| MP:0001672 | abnormal embryogenesis/ development | "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Irx6tm1Chow/Irx6tm1Chow,Vsx1tm1Mci/Vsx1tm1Mci
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ
Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6 * POMOD
|
| MP:0001697 | abnormal embryo size | "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Irx6tm1Chow/Irx6tm1Chow,Vsx1tm1Mci/Vsx1tm1Mci
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ
|
| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6 * POMOD
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| MP:0001701 | incomplete embryo turning | "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+
Genetic Background: C57BL/6J-ApcMin
Allelic Composition: Apctm1Tno/Apc+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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| MP:0001790 | abnormal immune system physiology | "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
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Allelic Composition: Apctm1Kk/Apctm1Kk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0001825 | arrested T cell development | "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apctm1Kk/Apctm1Kk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0001860 | liver inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0001883 | mammary adenocarcinoma | "higher than normal incidence of malignant tumors of the mammary gland" [J:62919] |
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Allelic Composition: Apctm1Cip/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Tno/Apc+,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: B6.129P2-Apctm2Rfo
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: 129P2/OlaHsd-Apctm2Rfo
Allelic Composition: Apctm2Rfo/Apc+,Smad4E6sad/Smad4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcM1Tno/Apc+
Genetic Background: either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)
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| MP:0002013 | pilomatriculoma | "hair follicle tumor" [J:51296] |
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Allelic Composition: ApcM1Tno/Apc+
Genetic Background: either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)
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| MP:0002016 | ovarian cysts | "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL
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| MP:0002018 | malignant tumors | "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427] |
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Allelic Composition: Fen1tm1Rak/Fen1+,Apctm1Rak/Apc+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL/J
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| MP:0002019 | abnormal tumor incidence | "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129S-Rag2tm1Fwa Mmp9tm1Tvu
Allelic Composition: ApcMin/Apc+,Igf2bp1tm1Vssp/Igf2bp1tm1Vssp,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL
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| MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1Tno/Apc+,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm1Rak/Apc+,Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2
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| MP:0002021 | increased incidence of induced tumors | "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
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| MP:0002038 | carcinoma | "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Apctm2Rak/Apctm2Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm2Rak/Apctm2Rak,Krastm4Tyj/Kras+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL
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| MP:0002044 | colonic adenoma | "benign tumors of the large intestine" [J:38772] |
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv
Allelic Composition: ApcMin/Apc+
Genetic Background: C57BL/6J-ApcMin
Allelic Composition: Apctm1Cip/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+,Recql4tm1Glu/Recql4tm1Glu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J
Allelic Composition: ApcMin/ApcMin,Rr27tm1Rohl/Rr27+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: ApcMin/Apc+,Slc5a8tm1.1Boet/Slc5a8tm1.1Boet
Genetic Background: involves: C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Foxl1tm1Khk/Foxl1tm1Khk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(CDX2-cre*)189Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: ApcMin/Apc+,Rab25tm1Jrgo/Rab25tm1Jrgo
Genetic Background: B6.Cg-Rab25tm1Jrgo ApcMin
Allelic Composition: Apctm1Tyj/Apc+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Apctm1.1Tyj/Apc+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: ApcMin/Apc+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Apctm2Rak/Apctm2Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm2Rak/Apctm2Rak,Krastm4Tyj/Kras+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL
Allelic Composition: ApcGt(XA018)Byg/Apc+
Genetic Background: B6.129P2-ApcGt(XA018)Byg
Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N
Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J
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| MP:0002045 | renal cystadenoma | "benign cystic neoplasm of the kidney derived from glandular epithelium origin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR
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| MP:0002052 | decreased tumor incidence | "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: ApcMin/Apc+,Mbd2tm1Bh/Mbd2tm1Bh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Mbd2tm1Bh/Mbd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J
Allelic Composition: ApcMin/Apc+,Dnmt3btm1Jae/Dnmt3btm1Jae,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * FVB/N
Allelic Composition: ApcMin/Apc+,Atp5a1Mom2/Atp5a1Mom2
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: ApcMin/Apc+,Atp5a1Mom2/Atp5a1+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: ApcMin/ApcMin,Sat1tm1Alh/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: ApcMin/Apc+,Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.Cg-Nos2tm1Lau ApcMin
Allelic Composition: ApcMin/Apc+,Nos2tm1Lau/Nos2+
Genetic Background: B6.Cg-Nos2tm1Lau ApcMin
Allelic Composition: ApcMin/Apc+,Hdac2Gt(W035F03)Joe/Hdac2Gt(W035F03)Joe
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: ApcMin/Apc+,Erbb3tm1.1Dwt/Erbb3tm2.1Dwt,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Apctm1Mmt/Apc+,Mmp7tm1Lmm/Mmp7tm1Lmm,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Allelic Composition: ApcMin/Apc+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm1Tno/Apctm1Tno,Ctnnb1tm4.1Wbm/Ctnnb1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: ApcMin/Apc+,Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL
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| MP:0002053 | decreased incidence of induced tumors | "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886] |
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: ApcMin/Apc+,Mom5129P2/OlaHsd/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Mmt/Apc+,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: ApcMin/ApcMin,Asphtm1Jed/Asphtm1Jed
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * C57BL/6NTac
Allelic Composition: ApcMin/Apc+
Genetic Background: C57BL/6J-ApcMin
Allelic Composition: Apctm2Tno/Apc+
Genetic Background: Not Specified
Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1Cip/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
Allelic Composition: ApcMin/Apc+,Mbd2tm1Bh/Mbd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Zbtb33tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm2.1Rak/Apc+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: ApcMin/Apc+,Mbd4tm1Bird/Mbd4tm1Bird
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm1.1Tno/Apc+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak +/+ Smad4E6sad
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: B6.129P2-Apctm1Rak
Allelic Composition: Apctm2.1Cip/Apc+,Krastm4Tyj/Kras+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Apctm1Mmt/Apc+,Smad2tm2Kato/Smad2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J
Allelic Composition: Apctm1Mmt/Apc+,Smad2tm1Kato/Smad2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J
Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6 * C57BL/6J
Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Fen1tm1Rak/Fen1+,Apctm1Rak/Apc+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL/J
Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(CDX2-cre*)189Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm1Tno/Apc+,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm1Rak/Apc+,Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: B6.129P2-Apctm2Rfo
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: 129P2/OlaHsd-Apctm2Rfo
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
Allelic Composition: ApcMin/Apc+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J
Allelic Composition: Apctm1.1Rsmi/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Apctm1.1Tyj/Apc+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: ApcMin/Apc+,Pms2tm1Lisk/Pms2tm1Lisk
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(Car1-cre)5Flt/0
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: ApcMin/Apc+,Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL
Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR
Allelic Composition: Apctm1.1Alew/Apc+
Genetic Background: B6.129-Apctm1.1Alew
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
Allelic Composition: ApcMin/Apc+
Genetic Background: B6(AKR)-ApcMin
Allelic Composition: ApcMin/Apc+,Cd44tm1Stpa/Cd44tm1Stpa
Genetic Background: involves: C57BL/6J * C57BL/6JIco
Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2
Allelic Composition: Apctm1Cip/Apc+,Nrip1tm1Mpk/Nrip1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcM1Tno/Apc+
Genetic Background: involves: C57BL/6 * DBA/2JJcl
Allelic Composition: ApcM1Tno/Apc+
Genetic Background: either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)
Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N
Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Apctm1Tno/Apctm1Tno,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Apctm2Rak/Apc+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J
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| MP:0002084 | abnormal developmental patterning | "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
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| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: involves: 129X1/SvJ * C57BL/6N
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| MP:0002095 | abnormal skin pigmentation | "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm2.1Rak/Apc+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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| MP:0002113 | abnormal skeleton development | "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002145 | abnormal T lymphocyte development | "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm1Kk/Apctm1Kk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
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| MP:0002166 | altered tumor susceptibility/resistance | "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sor/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sor ApcMin
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm2.1Rak/Apc+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0002396 | abnormal hematopoietic system morphology/development | "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: ApcMin/Apc+,Myctm1Jlc/Myc+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J
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| MP:0002404 | intestinal adenoma | "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Apctm1Mmt/Apc+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+
Genetic Background: C57BL/6J-ApcMin
Allelic Composition: Apctm2Tno/Apc+
Genetic Background: Not Specified
Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Eregtm1Dwt/Eregtm1Dwt
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Apctm1Cip/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J
Allelic Composition: Apctm1Kk/Apctm1Kk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Apctm4Mmt/Apc+
Genetic Background: B6.129X1-Apctm4Mmt
Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
Allelic Composition: ApcMin/Apc+,Zbtb33tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: Apctm2.1Rak/Apc+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: ApcMin/Apc+,Ptgdstm1Ohy/Ptgdstm1Ohy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Hpgdstm1Urad/Hpgds+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Hpgdstm1Urad/Hpgdstm1Urad
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Tg(CAG-PGDS)S-55Hjl/0
Genetic Background: involves: C57BL/6J * FVB/N
Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Mbd4tm1Bird/Mbd4tm1Bird
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/ApcMin,Rr27tm1Rohl/Rr27+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Apctm1.1Tno/Apc+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak +/+ Smad4E6sad
Allelic Composition: Apctm1Mmt/Apc+,Smad2tm2Kato/Smad2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J
Allelic Composition: Apctm1Mmt/Apc+,Smad2tm1Kato/Smad2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J
Allelic Composition: Apctm2Mmt/Apc+
Genetic Background: involves: 129X1/SvJ
Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2r+
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+,Mom5C57BL/6J/Mom5C57BL/6J
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Rab25tm1Jrgo/Rab25tm1Jrgo
Genetic Background: B6.Cg-Rab25tm1Jrgo ApcMin
Allelic Composition: ApcMin/Apc+,Rab25tm1Jrgo/Rab25+
Genetic Background: B6.Cg-Rab25tm1Jrgo ApcMin
Allelic Composition: Apctm1.1Rsmi/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Apctm1Tyj/Apc+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Apctm1.1Tyj/Apc+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: ApcMin/Apc+,Pms2tm1Lisk/Pms2tm1Lisk
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(Car1-cre)5Flt/0
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm2Rak/Apc+,Tg(Car1-cre)5Flt/0
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: ApcMin/Apc+,Gpa33tm1(GNAS)Wtsi/Gpa33+,Hprttm1(CMV-cre)Brd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL
Allelic Composition: ApcMin/Apc+,Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: ApcMin/Apc+,Tcf7l2tm2.2Mrc/Tcf7l2+
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1.1Alew/Apc+
Genetic Background: B6.129-Apctm1.1Alew
Allelic Composition: Apctm2.1Alew/Apc+
Genetic Background: B6.129-Apctm2.1Alew
Allelic Composition: ApcMin/Apc+,Col1a1tm9(tetO-Dnmt3b_i1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm2.1Cip/Apc+,Lrig1tm1.1(cre/ERT2)Rjc/Lrig1+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+,Il22ra2tm2Vlcg/Il22ra2tm2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: ApcMin/Apc+
Genetic Background: B6(AKR)-ApcMin
Allelic Composition: ApcGt(XA018)Byg/Apc+
Genetic Background: B6.129P2-ApcGt(XA018)Byg
Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Apctm2Cip/Apc+,Cdkn2atm1Cjs/Cdkn2atm1Cjs,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: ApcMin/Apc+,Cd44tm1Stpa/Cd44tm1Stpa
Genetic Background: involves: C57BL/6J * C57BL/6JIco
Allelic Composition: ApcMin/Apc+,Cd44tm1Stpa/Cd44tm2Stpa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Hsd11b2tm1.1Mzz/Hsd11b2tm1.1Mzz,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Mir10atm1.1Ahl/Mir10atm1.1Ahl
Genetic Background: B6.Cg-Mir10atm1.1Ahl Apcmin
Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Dnd1Ter/Dnd1+
Genetic Background: involves: 129P3/J * C57BL/6J
Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J
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| MP:0002435 | abnormal effector T cell morphology/development | "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic Background: involves: BALB/cJ
|
| MP:0002463 | abnormal neutrophil physiology | "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: C57BL/6J-ApcMin
Allelic Composition: Apctm2Tno/Apc+
Genetic Background: involves: C57BL/6J
|
| MP:0002656 | abnormal keratinocyte differentiation | "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum
" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0002691 | small stomach | "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0002732 | trichoepithelioma | "benign hair follicle tumors that lack mature hair follicles, derived from basal cells of the hair follicles enclosing small keratin cysts" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: ApcM1Tno/Apc+
Genetic Background: either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)
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| MP:0002816 | colitis | "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: ApcMin/Apc+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6J
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| MP:0002896 | abnormal bone mineralization | "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0002957 | intestinal adenocarcinoma | "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Mmt/Apc+,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: ApcMin/Apc+,Ppardtm1Jps/Ppardtm1Jps
Genetic Background: involves: 129/Sv * AKR/J * C57BL/6 * C57BL/6J
Allelic Composition: Apctm1Cip/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak +/+ Smad4E6sad
Allelic Composition: Apctm2.1Cip/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Apctm2.1Cip/Apc+,Krastm4Tyj/Kras+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Apctm1Rak/Apc+,Cdh1tm1Cbm/Cdh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Tgfbr1tm1Bopa/Tgfbr1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J
Allelic Composition: ApcMin/Apc+,Tgfbr1tm1Bopa/Tgfbr1+
Genetic Background: B6.Cg-Tgfbr1tm1Bopa ApcMin
Allelic Composition: Apctm1Cip/Apc+,H19tm1Lda/H19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+
Genetic Background: B6(AKR)-ApcMin
Allelic Composition: ApcMin/Apc+
Genetic Background: (AKR/J x C57BL/6J-ApcMin)F1
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J
|
| MP:0003068 | enlarged kidney | "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR
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| MP:0003085 | abnormal egg cylinder morphology | "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: involves: 129X1/SvJ * C57BL/6N
Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: AKR/J * C57BL/6J
|
| MP:0003104 | acrania | "complete or partial absence of a skull; usually associated with anencephaly" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:33716] |
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Allelic Composition: ApcMin/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1.1Tno/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * BALB/cJ * C57BL/6
|
| MP:0003257 | abnormal abdominal wall | "malformation in the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0003269 | colonic polyps | "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Apctm1Mmt/Apc+,Ptgs2tm1Jed/Ptgs2+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt
Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: B6.129P2-Apctm1Rak
Allelic Composition: ApcMin/Apc+,Tg(Rorc-EGFP)1Ebe/?
Genetic Background: involves: C57BL/6
Allelic Composition: ApcMin/Apc+,Foxl1tm1Khk/Foxl1tm1Khk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Cip/Apc+,H19tm1Lda/H19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: ApcMin/Apc+,Rab25tm1Jrgo/Rab25tm1Jrgo
Genetic Background: B6.Cg-Rab25tm1Jrgo ApcMin
Allelic Composition: Apctm2Rak/Apc+,Tg(Car1-cre)5Flt/0
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm1.1Klne/Apctm1.1Klne
Genetic Background: B6.129-Apctm1.1Klne
|
| MP:0003270 | intestinal obstruction | "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1.1Tno/Apc+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1Tno/Apc+,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm1.1Rsmi/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0003272 | duodenal atresia | "congenital blockage or absence of the lumen of the duodenum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Mpzl3rc/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3rc/Mpzl3tm1(KOMP)Mbp
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| MP:0003292 | melena | "dark colored, foul-smelling feces due to the presence of blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0003293 | rectal hemorrhage | "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Cip/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm2.1Rak/Apc+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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| MP:0003299 | gastric polyps | "abnormal tissue masses that protrude into the lumen of the stomach and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak +/+ Smad4E6sad
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: B6.129P2-Apctm1Rak
Allelic Composition: ApcMin/Apc+,Foxl1tm1Khk/Foxl1tm1Khk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1.1Klne/Apctm1.1Klne
Genetic Background: B6.129-Apctm1.1Klne
|
| MP:0003303 | peritoneal inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
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| MP:0003331 | hepatocellular carcinoma | "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
Allelic Composition: Apctm1Tno/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1Tno/Apc+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: ApcMin/Apctm1Tno,Ctnnb1tm4.1Wbm/Ctnnb1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
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| MP:0003414 | epidermal cyst | "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm1Mmt/Apc+,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
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| MP:0003447 | reduced tumor growth/size | "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383] |
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Allelic Composition: ApcMin/Apc+,Mbd2tm1Bh/Mbd2tm1Bh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Zbtb33tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.Cg-Nos2tm1Lau ApcMin
Allelic Composition: ApcMin/Apc+,Nos2tm1Lau/Nos2+
Genetic Background: B6.Cg-Nos2tm1Lau ApcMin
Allelic Composition: Apctm1Mmt/Apc+,Mmp7tm1Lmm/Mmp7tm1Lmm,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Allelic Composition: ApcMin/Apc+,Tg(Vil1-PPARGC1A)#Amos/0
Genetic Background: involves: C57BL/6J * FVB/N
Allelic Composition: Apctm1Tno/Apc+,Il23atm1Ngh/Il23atm1Ngh,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL/J
Allelic Composition: Apctm1Tno/Apc+,Il17ratm1Koll/Il17ratm1Koll,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL/J
Allelic Composition: Apctm1Tno/Apc+,Il23rtm1.2Trin/Il23rtm1.2Trin,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu,Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: ApcGt(XA018)Byg/Apc+
Genetic Background: (B6.129P2-ApcGt(XA018)Byg x C3H/HeJ)F1
Allelic Composition: ApcMin/Apc+,Hsd11b2tm1.1Mzz/Hsd11b2tm1.1Mzz,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Spata13tm1Taki ApcMin
Allelic Composition: ApcMin/Apc+,Spata13tm1Taki/Spata13+
Genetic Background: B6J.Cg-Spata13tm1Taki ApcMin
Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki ApcMin
Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4+
Genetic Background: B6J.Cg-Arhgef4tm1Taki ApcMin
Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin
Allelic Composition: Apctm1Tno/Apctm1Tno,Elp3tm1.1Tac/Elp3tm1.1Tac,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
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| MP:0003448 | altered tumor morphology | "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2r+
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1.1Alew/Apc+
Genetic Background: B6.129-Apctm1.1Alew
Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1+,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0003449 | abnormal intestinal goblet cells | "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0003574 | abnormal oviduct morphology | "malformation of the tube through which the ova pass from the ovary to the uterus" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL
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| MP:0003579 | ovarian carcinoma | |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR
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| MP:0003702 | abnormal chromosome morphology | "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt
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| MP:0003704 | abnormal hair follicle development | "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0003721 | increased tumor growth/size | "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: ApcMin/Apc+,Recql4tm1Glu/Recql4tm1Glu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Apctm1.1Tyj/Apc+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: ApcMin/Apc+,Col1a1tm9(tetO-Dnmt3b_i1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Il22ra2tm2Vlcg/Il22ra2tm2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: ApcGt(XA018)Byg/Apc+
Genetic Background: B6.129P2-ApcGt(XA018)Byg
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| MP:0003789 | osteosarcoma | "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: ApcM1Tno/Apc+
Genetic Background: either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)
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| MP:0003868 | abnormal feces composition | "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm2Rak/Apc+,Tg(Car1-cre)5Flt/0
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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| MP:0003884 | decreased macrophage count | "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: C57BL/6J-ApcMin
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| MP:0003886 | abnormal embryonic epiblast morphology | "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: involves: 129X1/SvJ * C57BL/6N
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| MP:0003887 | increased hepatocyte apoptosis | "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0003934 | abnormal pancreas development | "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mpzl3rc/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3rc/Mpzl3tm1(KOMP)Mbp
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| MP:0003963 | abnormal corticosterone level | "anomalous blood or tissue concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: ApcMin/Apc+,Hsd11b2tm1.1Mzz/Hsd11b2tm1.1Mzz,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0004024 | aneuploidy | "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: (AKR/J x C57BL/6J-ApcMin)F1
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| MP:0004045 | abnormal cell cycle checkpoint function | "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt
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| MP:0004066 | abnormal Henson s node morphology | "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
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| MP:0004187 | cardia bifida | "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
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| MP:0004200 | reduced fetal size | "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004344 | scapular bone hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, in either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004499 | increased incidence of chemically-induced tumors | "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: Apctm1Tno/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Apctm2Rak/Apc+,Tg(Car1-cre)5Flt/0
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: ApcMin/Apc+
Genetic Background: (AKR/J x C57BL/6J-ApcMin)F1
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| MP:0004500 | increased incidence of ionizing radiation-induced tumors | "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: T/tAE5
Genetic Background: Not Specified
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| MP:0004502 | decreased incidence of chemically-induced tumors | "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sor/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sor ApcMin
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| MP:0004672 | short ribs | "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004713 | split notochord | "the appearance of an abnormal division in the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
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| MP:0004733 | abnormal thoracic cavity | "any structural anomaly of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004790 | absent upper incisors | "missing the upper pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0004833 | ovary atrophy | "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
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| MP:0004841 | abnormal small intestine crypts of Lieberkuhn morphology | "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0004842 | abnormal large intestine crypts of Lieberkuhn morphology | "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
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| MP:0004843 | abnormal Paneth cell morphology | "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
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| MP:0004894 | uterus atrophy | "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
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| MP:0004973 | increased regulatory T cell number | "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
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| MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apctm1.1Tno/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * BALB/cJ * C57BL/6
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| MP:0005090 | increased double-negative T cells count | "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Apctm1Kk/Apctm1Kk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0005141 | liver hyperplasia | "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
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| MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: ApcMin/Apc+,Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Apctm2Cip/Apc+,Cdkn2atm1Cjs/Cdkn2atm1Cjs,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm2Tno/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm2Rak/Apc+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL
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| MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0005220 | abnormal exocrine pancreas morphology | "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mir122tm1.1Kgh/Mir122+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0005296 | abnormal humerus morphology | "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005565 | increased blood urea nitrogen level | "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR
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| MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm1Rak/Apc+,Mbd4tm1Wed/Mbd4tm1Wed
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: ApcMin/Apc+,Foxl1tm1Khk/Foxl1tm1Khk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Fen1tm1Rak/Fen1+,Apctm1Rak/Apc+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL/J
Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J
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| MP:0006000 | abnormal corneal epithelium | "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt
Allelic Composition: Apctm1.1Alew/Apc+
Genetic Background: B6.129-Apctm1.1Alew
Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Apctm2Cip/Apc+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0006043 | decreased apoptosis | "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt
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| MP:0006108 | abnormal hindbrain development | "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
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| MP:0006279 | abnormal limb development | "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0006401 | absent preputial gland | "a lack of the sebaceous glands of the corona and neck of the glans penis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0006422 | mammary adenoacanthoma | "higher than normal incidence of malignant tumors in which some cells have undergone squamous metaplasia in the mammary gland" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0008000 | ovary tumor | "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL
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| MP:0008011 | intestinal polyps | "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Mmt/Apc+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: ApcMin/Apc+,Ppardtm1Jps/Ppardtm1Jps
Genetic Background: involves: 129/Sv * AKR/J * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1Kk/Apctm1Kk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Apctm4Mmt/Apc+
Genetic Background: B6.129X1-Apctm4Mmt
Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm1.1Tno/Apc+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: B6.129P2-Apctm1Rak
Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: involves: 129X1/SvJ * C57BL/6N
Allelic Composition: ApcMin/Apc+,Myctm1Jlc/Myc+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2r+
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Tg(Rorc-EGFP)1Ebe/?
Genetic Background: involves: C57BL/6
Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(CDX2-cre*)189Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: ApcMin/Apc+,Dnmt1tm1Pwl/Dnmt1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: ApcMin/Apc+,Dnmt1tm1Jae/Dnmt1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: ApcMin/Apc+,Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: B6.Cg-Pla2g4atm1Jvb ApcMin
Allelic Composition: ApcMin/Apc+,Erbb3tm1.1Dwt/Erbb3tm2.1Dwt,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Allelic Composition: ApcMin/Apc+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: ApcMin/Apctm1Tno,Ctnnb1tm4.1Wbm/Ctnnb1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: ApcMin/Apc+,Pms2tm1Lisk/Pms2tm1Lisk
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: ApcMin/Apc+,Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL
Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne
Allelic Composition: ApcMin/Apc+,Rr21tm1.1Jta/Rr21tm1.1Jta
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: ApcMin/Apc+,Rr21tm1Jta/Rr21+
Genetic Background: involves: C57BL/6
Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6
Allelic Composition: Apctm2Tno/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcGt(XA018)Byg/Apc+
Genetic Background: B6.129P2-ApcGt(XA018)Byg
Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2+,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N
Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J
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| MP:0008012 | duodenal polyps | "development of numerous growths that are connected to and protrude from the mucous membrane of the duodenum" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J
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| MP:0008019 | liver tumor | "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: B6.129P2-Apctm2Rfo
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: 129P2/OlaHsd-Apctm2Rfo
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| MP:0008039 | increased NK T cell number | "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0008040 | decreased NK T cell number | "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
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| MP:0008042 | abnormal NK T cell physiology | "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0008045 | decreased NK cell number | "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0008058 | abnormal DNA repair | "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281] |
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Allelic Composition: ApcMin/Apc+,Mbd4tm1Bird/Mbd4tm1Bird
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0008078 | increased CD8-positive T cell number | "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
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| MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008272 | abnormal endochondral bone ossification | "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008466 | enlarged mesenteric lymph nodes | "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: ApcMin/Apc+,Tg(Rorc-EGFP)1Ebe/?
Genetic Background: involves: C57BL/6
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| MP:0008528 | polycystic kidney | "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR
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| MP:0008533 | abnormal anterior visceral endoderm | "any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
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| MP:0008553 | increased circulating tumor necrosis factor level | "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Apctm1Kk/Apctm1Kk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
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| MP:0008567 | decreased interferon-gamma secretion | "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0008657 | increased interleukin-1 beta secretion | "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
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| MP:0008660 | increased interleukin-10 secretion | "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510] |
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
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| MP:0008699 | increased interleukin-4 secretion | "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0008713 | abnormal cytokine level | "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2Rak/Apc+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL
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| MP:0008721 | abnormal chemokine level | "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0008762 | embryonic lethality | "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Slc5a8tm1.1Boet/Slc5a8tm1.1Boet
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0008780 | pancreatic acinar cell carcinoma | "presence of an adenocarcinoma arising from cells of the pancreas that secrete digestive enzymes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mir122tm1.1Kgh/Mir122+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008800 | increased small intestinal crypt cell apoptosis | "increase in the number of small intestinal crypt cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl
Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008866 | chromosomal instability | "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840] |
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Allelic Composition: ApcMin/Apc+,Hltftm1.1Hdin/Hltftm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0008874 | decreased sensitivity to xenobiotics | "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin
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| MP:0008877 | abnormal DNA methylation | "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306] |
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Allelic Composition: ApcMin/Apc+,Col1a1tm9(tetO-Dnmt3b_i1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
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| MP:0008883 | abnormal enterocyte proliferation | "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Esr2tm1Mma/Esr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: ApcMin/Apc+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Apctm1.1Klne/Apctm1.1Klne
Genetic Background: B6.129-Apctm1.1Klne
Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne
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| MP:0008885 | increased enterocyte apoptosis | "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Cd44tm1Stpa/Cd44tm2Stpa
Genetic Background: involves: C57BL/6J
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| MP:0009078 | adrenal gland hyperplasia | "overdevelopment or increased size, usually due to a increased number of cells, of the endocrine glands located above the kidney and responsible for hormone and epinephrine secretion" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
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| MP:0009092 | endometrium hyperplasia | "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL
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| MP:0009114 | decreased pancreatic beta cell mass | "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpzl3rc/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3rc/Mpzl3tm1(KOMP)Mbp
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| MP:0009151 | pancreatic ductal adenocarcinoma | "adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750] |
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Allelic Composition: Apctm1Mmt/Apc+,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0009153 | pancreas tumor | "tumors or cancer of the pancreas" [MESH:C04.588.274.761] |
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Allelic Composition: Apctm2Rak/Apc+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL
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| MP:0009168 | decreased pancreatic islet number | "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414] |
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Allelic Composition: Mpzl3rc/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3rc/Mpzl3tm1(KOMP)Mbp
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| MP:0009209 | abnormal internal female genitalia morphology | "any structural anomaly of the internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0009219 | prostate intraepithelial neoplasia | "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2
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| MP:0009220 | prostate adenocarcinoma | "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2
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| MP:0009266 | abnormal mesendoderm development | "failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm3Mmt/Apc+
Genetic Background: B6.129X1-Apctm3Mmt
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| MP:0009308 | adenocarcinoma | "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm2Rak/Apctm2Rak,Krastm4Tyj/Kras+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL
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| MP:0009309 | small intestine adenocarcinoma | "malignant neoplasm of epithelial cells in the small intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Tno/Apc+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: ApcMin/Apc+,Hdac2Gt(W035F03)Joe/Hdac2Gt(W035F03)Joe
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Apctm1.1Rsmi/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Aestm1.1Mmt/Aestm1.1Mmt,Apctm1Mmt/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA * SJL
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J
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| MP:0009310 | large intestine adenocarcinoma | "malignant neoplasm of epithelial cells in the large intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1.1Rsmi/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0009314 | colon adenocarcinoma | "malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aestm1.1Mmt/Aestm1.1Mmt,Apctm1Mmt/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA * SJL
Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J
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| MP:0009339 | decreased splenocyte number | "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0009539 | abnormal Hassall s corpuscle morphology | "any strucutral anomaly of the small spherical bodies of epithelial cells found in the medulla of the thymus, that are arranged in a concentric pattern around clusters of degenerating lymphocytes, eosinophils and macrophages" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0009661 | abnormal pregnancy | "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: B6(AKR)-ApcMin
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| MP:0009733 | absent nipple | "absence of the erectile projection at the apex of the mammary gland where the lactiferous ducts open" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
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| MP:0009764 | decreased sensitivity to induced morbidity/mortality | "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu,Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0009814 | increased prostaglandin level | "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: ApcMin/Apc+
Genetic Background: C57BL/6J-ApcMin
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| MP:0009815 | decreased prostaglandin level | "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: ApcMin/Apc+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0009828 | delayed tumor appearance | "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: ApcMin/Apc+,Elp3tm1.1Tac/Elp3tm1.1Tac,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
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| MP:0009850 | embryonic lethality between implantation and placentation | "death anytime after implantation but before placentation (Mus: E4.5 to less than E9)" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6 * POMOD
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| MP:0010144 | abnormal tumor vascularization | "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin
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| MP:0010155 | abnormal intestine physiology | "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
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| MP:0010156 | abnormal small intestinal crypt cell physiology | "altered function of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Elp3tm1.1Tac/Elp3tm1.1Tac,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
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| MP:0010158 | abnormal intestine development | "abnormal formation of the digestive tube passing from the stomach to the anus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0010269 | decreased mammary gland tumor incidence | "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6
Allelic Composition: ApcMin/Apc+,Mmom1C57BL/6J/Mmom1FVB/NTac,Mmom3C57BL/6J/Mmom3FVB/NTac
Genetic Background: involves: C57BL/6J * FVB/NTac
Allelic Composition: ApcMin/Apc+,Mmom2C57BL/6J/Mmom2FVB/NTac
Genetic Background: involves: C57BL/6J * FVB/NTac
Allelic Composition: ApcMin/Apc+,Mmom2129X1/SvJ/Mmom2C57BL/6J
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: ApcMin/Apc+,Mmom2C57BL/6J/Mmom2FVB/NTac,Mmom3C57BL/6J/Mmom3FVB/NTac
Genetic Background: involves: C57BL/6J * FVB/NTac
Allelic Composition: ApcMin/Apc+,Mmom2C57BL/6J/Mmom2FVB/NTac,Mmom4C57BL/6J/Mmom4FVB/NTac
Genetic Background: involves: C57BL/6J * FVB/NTac
Allelic Composition: ApcMin/Apc+,Mmom4C57BL/6J/Mmom4FVB/NTac
Genetic Background: involves: C57BL/6J * FVB/NTac
Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sor/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sor ApcMin
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| MP:0010273 | increased classified tumor incidence | "greater than the expected number of tumors with a specific classification type in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J
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| MP:0010274 | increased organ/body region tumor incidence | "greater than the expected number of tumors originating in a specific body region or organ in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2Rak/Apctm2Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm2Rak/Apctm2Rak,Krastm4Tyj/Kras+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL
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| MP:0010279 | increased gastrointestinal tumor incidence | "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/ApcMin,Asphtm1Jed/Asphtm1Jed
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * C57BL/6NTac
Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J
Allelic Composition: ApcMin/Apc+,Hptm1Skl/Hptm1Skl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm2.1Rak/Apc+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Apctm1Rak/Apc+,Mbd4tm1Wed/Mbd4tm1Wed
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: ApcMin/Apc+,Tgfbr1tm1Bopa/Tgfbr1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J
Allelic Composition: ApcMin/Apc+,Tgfbr1tm1Bopa/Tgfbr1+
Genetic Background: B6.Cg-Tgfbr1tm1Bopa ApcMin
Allelic Composition: Fen1tm1Rak/Fen1+,Apctm1Rak/Apc+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL/J
Allelic Composition: Apctm1Tno/Apc+,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm1Tno/Apc+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm1.1Rsmi/Apc+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: 129P2/OlaHsd-Apctm2Rfo
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
Allelic Composition: Apctm2Rfo/Apc+,Smad4E6sad/Smad4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J
Allelic Composition: ApcMin/Apc+,Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Apctm1.1Rsmi/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: ApcMin/Apc+,Esr2tm1Mma/Esr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: ApcMin/Apc+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Apctm1Tno/Apc+,Tg(CDX2-cre/ERT)#Erf/0
Genetic Background: involves: 129S4/SvJae
Allelic Composition: ApcMin/Apc+,Mir10atm1.1Ahl/Mir10atm1.1Ahl
Genetic Background: B6.Cg-Mir10atm1.1Ahl Apcmin
Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N
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| MP:0010287 | increased reproductive system tumor incidence | "greater than the expected number of tumors originating in the reproductive system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0010299 | increased mammary gland tumor incidence | "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcMin/Apc+,Brca2tm1Mbn/Brca2+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: B6.129P2-Apctm2Rfo
Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
Allelic Composition: ApcMin/Apc+
Genetic Background: B6(AKR)-ApcMin
Allelic Composition: ApcM1Tno/Apc+
Genetic Background: involves: C57BL/6 * DBA/2JJcl
Allelic Composition: ApcM1Tno/Apc+
Genetic Background: either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)
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| MP:0010300 | increased skin tumor incidence | "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: ApcM1Tno/Apc+
Genetic Background: involves: C57BL/6 * DBA/2JJcl
Allelic Composition: ApcM1Tno/Apc+
Genetic Background: either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)
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| MP:0010301 | increased stomach tumor incidence | "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Rak/Apc+,Cdh1tm1Cbm/Cdh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
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| MP:0010313 | increased osteoma incidence | "greater than the expected number of benign neoplasms derived from lamellar bone, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcM1Tno/Apc+
Genetic Background: involves: C57BL/6 * DBA/2JJcl
Allelic Composition: ApcM1Tno/Apc+
Genetic Background: either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)
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| MP:0010318 | increased salivary gland tumor incidence | "greater than the expected number of neoplams in the salivary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0010338 | increased desmoid tumor incidence | "greater than the expected number of a monoclonal, fibroblastic proliferation arising in musculoaponeurotic structures in a specific population in a given time period; this connective tissue hyperplasia infiltrates locally, recurs frequently after resection but does not metastasize; this tumor may occur at the site of any fascia, but in particular in muscle" [PMID:18023087] |
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Allelic Composition: Apctm2Rfo/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
Allelic Composition: Apctm1Rak/Apc+
Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1
Allelic Composition: Apctm1.1Rsmi/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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| MP:0010352 | gastrointestinal tract polyps | "abnormal tissue masses that protrude into the lumen of the gastrointestinal tract and are tethered to the wall of the gastrointestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1.1Alew/Apc+
Genetic Background: B6.129-Apctm1.1Alew
Allelic Composition: Apctm2.1Alew/Apc+
Genetic Background: B6.129-Apctm2.1Alew
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| MP:0010377 | abnormal gut flora balance | "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
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| MP:0010383 | increased adenoma incidence | "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035] |
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Allelic Composition: ApcMin/Apc+,Recql4tm1Glu/Recql4tm1Glu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Apctm1Cip/Apc+,H19tm1Lda/H19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1.1Alew/Apc+
Genetic Background: B6.129-Apctm1.1Alew
Allelic Composition: Apctm2.1Alew/Apc+
Genetic Background: B6.129-Apctm2.1Alew
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| MP:0010639 | altered tumor pathology | "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm2.1Alew/Apc+
Genetic Background: B6.129-Apctm2.1Alew
Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin
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| MP:0010769 | abnormal survival | "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Cd44tm1Stpa/Cd44tm1Stpa
Genetic Background: involves: C57BL/6J * C57BL/6JIco
Allelic Composition: ApcMin/Apc+,Cd44tm1Mak/Cd44tm1Mak
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Spata13tm1Taki ApcMin
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(CDX2-cre*)189Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm1Rsmi/Apctm1Rsmi,Tg(Col2a1-cre)1Rsjo/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Apctm2Rfo/Apctm2Rfo
Genetic Background: B6.129P2-Apctm2Rfo
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Eaf2tm1Zhow/Eaf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: ApcMin/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1.1Tno/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * BALB/cJ * C57BL/6
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi,Tg(Col2a1-cre)1Rsjo/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Apctm1Hsa/Apctm1Hsa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm2.1Alew/Apctm2.1Alew
Genetic Background: B6.129-Apctm2.1Alew
Allelic Composition: Apctm1.1Alew/Apctm1.1Alew
Genetic Background: B6.129-Apctm1.1Alew
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Apctm1Mmt/Apc+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Apctm1Rak/Apc+,Ctnnb1tm1.2Wvv/Ctnnb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm2Rfo/Apc+,Ctnnb1tm1.2Wvv/Ctnnb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ
Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6 * POMOD
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| MP:0011096 | complete embryonic lethality before somite formation | "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith] |
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Allelic Composition: ApcMin/ApcMin,Ctnnb1tm4.1Wbm/Ctnnb1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss
Allelic Composition: Apctm3Mmt/Apctm3Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6N
Allelic Composition: ApcM1Tno/ApcM1Tno
Genetic Background: involves: C57BL/6 * DBA/2JJcl
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| MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: ApcMin/Apc+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6J
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| MP:0011106 | partial embryonic lethality before somite formation | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska
Genetic Background: involves: C57BL/6 * CBA
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| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: ApcMin/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
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| MP:0011278 | increased ear pigmentation | "visually detectable excess of pigment present in the outer ear" [MGI:csmith] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0011635 | abnormal mitochondrial crista morphology | "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061] |
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Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J
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| MP:0011710 | increased osteoblast differentiation | |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi,Tg(Col2a1-cre)1Rsjo/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0012087 | absent midbrain | "absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna] |
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Allelic Composition: Apctm3Mmt/Apctm3Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6N
Allelic Composition: ApcMin/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1.1Tno/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * BALB/cJ * C57BL/6
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| MP:0012135 | embryonic-extraembryonic boundary constriction | "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith] |
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Allelic Composition: Apctm3Mmt/Apctm3Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6N
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| MP:0012136 | absent forebrain | "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853] |
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Allelic Composition: Apctm3Mmt/Apctm3Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6N
Allelic Composition: ApcMin/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Apctm1.1Tno/Apctm1Tno
Genetic Background: involves: 129/Sv * 129S4/SvJae * BALB/cJ * C57BL/6
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| MP:0012156 | rostral-caudal axis duplication | "partial or complete duplication of rostral-caudal axis structures" [MGI:anna] |
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Allelic Composition: Apctm3Mmt/Apctm3Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6N
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| MP:0012157 | rostral body truncation | "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith] |
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Allelic Composition: Apctm3Mmt/Apctm3Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6N
Allelic Composition: Apctm1Rak/Apc+,Ctnnb1tm1.2Wvv/Ctnnb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apctm2Rfo/Apc+,Ctnnb1tm1.2Wvv/Ctnnb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0012165 | absent neural folds | "absence of the elevated margins of the neural groove" [MGI:csmith] |
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Allelic Composition: Apctm3Mmt/Apctm3Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6N
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| MP:0012176 | abnormal head development | "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323] |
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Allelic Composition: Apctm3Mmt/Apctm3Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6N
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| MP:0012411 | increased granulosa cell tumor incidence | "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432] |
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0012424 | decreased alimentary system tumor incidence | "less than the expected number of tumors originating in the alimentary system in a given population in a given time period" [MGI:csmith] |
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Allelic Composition: ApcMin/Apc+,Tg(Vil1-PPARGC1A)#Amos/0
Genetic Background: involves: C57BL/6J * FVB/N
Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sor/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sor ApcMin
Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J
Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1
Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Apctm2Cip/Apc+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Bmi1tm1.1Lees/Bmi1tm1.1Lees,Apctm2Cip/Apc+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: ApcMin/Apc+,Tniktm1Teya/Tniktm1Teya
Genetic Background: involves: C57BL/6J
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| MP:0012431 | increased lymphoma incidence | "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith] |
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Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0012434 | decreased intestinal adenoma incidence | "less than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period" [MGI:csmith] |
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl
Allelic Composition: ApcMin/Apc+
Genetic Background: (AKR/J x C57BL/6J-ApcMin)F1
Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1
Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Apctm2Cip/Apc+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Bmi1tm1.1Lees/Bmi1tm1.1Lees,Apctm2Cip/Apc+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: ApcMin/Apc+,Cd44tm2Stpa/Cd44tm2Stpa
Genetic Background: involves: C57BL/6J
Allelic Composition: ApcMin/Apc+,Cd44tm1Mak/Cd44tm1Mak
Genetic Background: involves: C57BL/6J
Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
Allelic Composition: ApcMin/Apc+
Genetic Background: (MA/MyJ x C57BL/6J-ApcMin)F1
Allelic Composition: ApcMin/Apc+,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Spata13tm1Taki ApcMin
Allelic Composition: ApcMin/Apc+,Spata13tm1Taki/Spata13+
Genetic Background: B6J.Cg-Spata13tm1Taki ApcMin
Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki ApcMin
Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4+
Genetic Background: B6J.Cg-Arhgef4tm1Taki ApcMin
Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin
Allelic Composition: ApcMin/Apc+,Elp3tm1.1Tac/Elp3tm1.1Tac,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
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| MP:0012435 | decreased colon tumor incidence | "less than the expected number of neoplasms in the colon, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith] |
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Allelic Composition: Bmi1tm1Brn/Bmi1tm1Brn,Apctm2Cip/Apc+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Bmi1tm1.1Lees/Bmi1tm1.1Lees,Apctm2Cip/Apc+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
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| MP:0012436 | increased colon tumor incidence | "greater than the expected number of neoplasms in the colon, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith] |
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Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N
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| MP:0012700 | abnormal endocardial heart tube morphology | "any structural anomaly of the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube" [MGI:anna] |
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Allelic Composition: Apctm3Mmt/Apctm3Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6N
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| MP:0013184 | hemorrhagic ascites | "the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity" [MGI:anna] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0013443 | Harderian gland hyperplasia | "overdevelopment or increased size, usually due to an increased number of cells, of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane" [MGI:Anna] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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| MP:0013654 | increased CD103-positive CD11b-low dendritic cell number | "increase in the number of CD11b-low dendritic cells expressing CD103, a marker of tissue residency" [MGI:Saran, PMID:23516985] |
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
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| MP:0013751 | increased cystadenoma incidence | "greater than the expected number of a histologically benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed, occurring in a specific population in a given time period; in some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic" [http://medical-dictionary.thefreedictionary.com/cystoadenoma, MGI:Anna] |
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Allelic Composition: Apctm2Rak/Apc+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL
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| MP:0013795 | abnormal colon goblet cell morphology | "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481] |
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Allelic Composition: ApcMin/Apc+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
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| MP:0020324 | jejunum polyps | "development of numerous growths that are connected to and protrude from the mucous membrane of the jejunum" [ORCID: orcid.org/0000-0003-4606-0597, PMID:25578479] |
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Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J
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| MP:0030053 | increased forehead pigmentation | "visually detectable excess of pigment present in the forehead" [MGI:anna] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
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