ENSMUSG00000020135


Mus musculus

Features
Gene ID: ENSMUSG00000020135
  
Biological name :Apc2
  
Synonyms : Apc2 / APC2, WNT signaling pathway regulator
  
Possible biological names infered from orthology : O95996
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 80295977
Gene end: 80318263
  
Corresponding Affymetrix probe sets: 10364769 (MoGene1.0st)   1422129_at (Mouse Genome 430 2.0 Array)   1435199_at (Mouse Genome 430 2.0 Array)   1450497_at (Mouse Genome 430 2.0 Array)   1455231_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020349
Ensembl peptide - ENSMUSP00000121324
Ensembl peptide - ENSMUSP00000118171
Ensembl peptide - ENSMUSP00000116795
Ensembl peptide - ENSMUSP00000100996
NCBI entrez gene - 23805     See in Manteia.
MGI - MGI:1346052
RefSeq - XM_006513646
RefSeq - NM_011789
RefSeq - XM_006513643
RefSeq - XM_006513644
RefSeq - XM_006513645
RefSeq Peptide - NP_035919
swissprot - D3Z3K9
swissprot - D3YYQ9
swissprot - D3YTR0
swissprot - G5E832
swissprot - D3Z344
Ensembl - ENSMUSG00000020135
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apc2ENSDARG00000063007Danio rerio
 APC2ENSGALG00000042153Gallus gallus
 APC2ENSG00000115266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Apc / APC, WNT signaling pathway regulator / P25054*ENSMUSG0000000587138


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR009223  Adenomatous polyposis coli protein repeat
 IPR009224  SAMP
 IPR009234  Adenomatous polyposis coli protein basic domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR026818  Adenomatous polyposis coli (APC) family
 IPR026831  Adenomatous polyposis coli protein
 IPR026837  Adenomatous polyposis coli 2
 IPR032038  Adenomatous polyposis coli, N-terminal dimerisation domain
 IPR036149  APC, N-terminal coiled-coil domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005881 cytoplasmic microtubule IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016342 catenin complex IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0031941 filamentous actin IEA
 cellular_componentGO:0045171 intercellular bridge IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008284 abnormal hippocampus pyramidal cell layer 
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008285 abnormal hippocampus granule cell layer 
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009946 abnormal olfactory bulb layer morphology "any structural anomaly of the laminar structure of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009951 abnormal olfactory bulb mitral cell layer morphology 
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009956 abnormal cerebellar layer morphology "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010011 ectopic hippocampus pyramidal cells "the hippocampus pyramidal cell body resides in places other than the pyramidal cell layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010540 long stride length "increased average distance between steps" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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