ENSGALG00000004288


Gallus gallus

Features
Gene ID: ENSGALG00000004288
  
Biological name :HDAC4
  
Synonyms : HDAC4 / Histone deacetylase 4 / P83038
  
Possible biological names infered from orthology : P56524 / Q6NZM9
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 6185856
Gene end: 6415782
  
Corresponding Affymetrix probe sets: Gga.3689.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000049845
Ensembl peptide - ENSGALP00000057708
Ensembl peptide - ENSGALP00000033098
NCBI entrez gene - 374207     See in Manteia.
RefSeq - XM_015289096
RefSeq - XM_015289091
RefSeq - XM_015289092
RefSeq - XM_015289093
RefSeq - XM_015289094
RefSeq - XM_015289095
RefSeq - NM_204313
RefSeq - XM_015289087
RefSeq - XM_015289088
RefSeq - XM_015289089
RefSeq - XM_015289090
RefSeq Peptide - NP_989644
swissprot - A0A1D5PXL2
swissprot - F1NP26
swissprot - A0A1D5PAT1
swissprot - P83038
Ensembl - ENSGALG00000004288
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac4ENSDARG00000098349Danio rerio
 HDAC4ENSG00000068024Homo sapiens
 Hdac4ENSMUSG00000026313Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HDAC9 / histone deacetylase 9 / Q9UKV0*ENSGALG0000001085458
HDAC7 / histone deacetylase 7 / Q8C2B3* / Q8WUI4*ENSGALG0000003971046
HDAC10 / histone deacetylase 10 / Q6P3E7* / Q969S8*ENSGALG000000412519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR017320  Histone deacetylase class II, eukaryotic
 IPR023801  Histone deacetylase domain
 IPR024643  Histone deacetylase, glutamine rich N-terminal domain
 IPR033660  Histone deacetylase 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010832 negative regulation of myotube differentiation IEA
 biological_processGO:0010882 regulation of cardiac muscle contraction by calcium ion signaling IEA
 biological_processGO:0014894 response to denervation involved in regulation of muscle adaptation IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0030183 B cell differentiation TAS
 biological_processGO:0033235 positive regulation of protein sumoylation IEA
 biological_processGO:0034983 peptidyl-lysine deacetylation IEA
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0042113 B cell activation TAS
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045820 negative regulation of glycolytic process IEA
 biological_processGO:0045843 negative regulation of striated muscle tissue development TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048742 regulation of skeletal muscle fiber development IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051153 regulation of striated muscle cell differentiation IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0070933 histone H4 deacetylation IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IEA
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0042641 actomyosin IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030955 potassium ion binding IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033558 protein deacetylase activity IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
RUNX3 regulates p14-ARF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000000156 BRD2 / bromodomain-containing protein 2 / P25440* / Q7JJ13* / bromodomain containing 2*  / complex / reaction






 

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