ENSGALG00000009228


Gallus gallus

Features
Gene ID: ENSGALG00000009228
  
Biological name :PARP1
  
Synonyms : PARP1 / poly
  
Possible biological names infered from orthology : P09874 / poly(ADP-ribose) polymerase 1 / poly (ADP-ribose) polymerase family, member 1
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 17031435
Gene end: 17061424
  
Corresponding Affymetrix probe sets: Gga.5209.1.S1_a_at (Chicken Array)   Gga.5209.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000061194
Ensembl peptide - ENSGALP00000038037
NCBI entrez gene - 396199     See in Manteia.
RefSeq - NM_205263
RefSeq Peptide - NP_990594
swissprot - F1NL05
swissprot - A0A1L1RQW4
Ensembl - ENSGALG00000009228
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 parp1ENSDARG00000019529Danio rerio
 PARP1ENSG00000143799Homo sapiens
 Parp1ENSMUSG00000026496Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PARP3 / poly(ADP-ribose) polymerase family member 3 / Q9Y6F1*ENSGALG0000000451717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR001510  Zinc finger, PARP-type
 IPR004102  Poly(ADP-ribose) polymerase, regulatory domain
 IPR008288  Poly [ADP-ribose] polymerase
 IPR008893  WGR domain
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR012982  PADR1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0018312 peptidyl-serine ADP-ribosylation IEA
 biological_processGO:0032042 mitochondrial DNA metabolic process IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0036211 protein modification process IEA
 biological_processGO:0043504 mitochondrial DNA repair IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0070212 protein poly-ADP-ribosylation IEA
 biological_processGO:1903518 positive regulation of single strand break repair IEA
 biological_processGO:1903827 regulation of cellular protein localization IEA
 biological_processGO:1990966 ATP generation from poly-ADP-D-ribose IEA
 biological_processGO:2001170 negative regulation of ATP biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:1990404 protein ADP-ribosylase activity IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002117 PARG / poly(ADP-ribose) glycohydrolase / O88622* / Q86W56*  / reaction
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / reaction
 ENSGALG00000008559 CUL4B / cullin 4B / A2A432* / Q13620*  / complex / reaction
 ENSGALG00000006357 XPC / XPC complex subunit, DNA damage recognition and repair factor / P51612* / Q01831* / xeroderma pigmentosum, complementation group C*  / complex / reaction
 ENSGALG00000008218 DDB2 / Q5ZJL7 / DNA damage-binding protein 2 / Q92466* / Q99J79* / damage specific DNA binding protein 2*  / reaction / complex
 ENSGALG00000007510 CETN2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / complex / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000042333 DDB1 / Q805F9 / DNA damage-binding protein 1 / Q16531* / Q3U1J4* / damage specific DNA binding protein 1*  / reaction / complex
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSGALG00000033781 FEN1 / Q5ZLN4 / Flap endonuclease 1 / P39748* / flap structure-specific endonuclease 1*  / complex / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSGALG00000009228 PARP1 / poly / P09874* / poly(ADP-ribose) polymerase 1* / poly (ADP-ribose) polymerase family, member 1*  / complex
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction






 

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