ENSGALG00000008559


Gallus gallus

Features
Gene ID: ENSGALG00000008559
  
Biological name :CUL4B
  
Synonyms : CUL4B / cullin 4B
  
Possible biological names infered from orthology : A2A432 / Q13620
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 16458726
Gene end: 16479086
  
Corresponding Affymetrix probe sets: Gga.10466.1.S1_s_at (Chicken Array)   Gga.8809.1.S1_at (Chicken Array)   GgaAffx.22632.1.S1_at (Chicken Array)   GgaAffx.22632.1.S1_s_at (Chicken Array)   GgaAffx.22632.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013926
Ensembl peptide - ENSGALP00000048714
NCBI entrez gene - 422364     See in Manteia.
RefSeq - XM_420335
swissprot - A0A1D5P7M3
swissprot - E1BQK9
Ensembl - ENSGALG00000008559
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul4bENSDARG00000060510Danio rerio
 CUL4BENSG00000158290Homo sapiens
 Cul4bENSMUSG00000031095Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CUL4A / cullin 4A / Q13619* / Q3TCH7*ENSGALG0000001683072
CUL3 / cullin 3 / Q13618* / Q9JLV5*ENSGALG0000000510833
CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*ENSGALG0000003694126
CUL2 / cullin-2 / Q13617* / Q9D4H8*ENSGALG0000000709524
CUL5 / cullin 5 / Q93034*ENSGALG0000001716523


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR011991  ArsR-like helix-turn-helix domain
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain
 IPR033044  Cullin-4B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0010498 proteasomal protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0035518 histone H2A monoubiquitination IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0070914 UV-damage excision repair IEA
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031465 Cul4B-RING E3 ubiquitin ligase complex IBA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006254 ERCC6 / ERCC excision repair 6, chromatin remodeling factor / P0DP91* / Q03468* / Q8N328*  / reaction / complex
 ENSGALG00000042333 DDB1 / Q805F9 / DNA damage-binding protein 1 / Q16531* / Q3U1J4* / damage specific DNA binding protein 1*  / complex
 ENSGALG00000007510 CETN2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / complex / reaction
 ENSGALG00000009837 DTL / Q5ZJW8 / Denticleless protein homolog / Q3TLR7* / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*  / complex
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / reaction / complex
 ENSGALG00000009228 PARP1 / poly / P09874* / poly(ADP-ribose) polymerase 1* / poly (ADP-ribose) polymerase family, member 1*  / reaction / complex
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / reaction / complex
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / reaction / complex
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSGALG00000006357 XPC / XPC complex subunit, DNA damage recognition and repair factor / P51612* / Q01831* / xeroderma pigmentosum, complementation group C*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000008218 DDB2 / Q5ZJL7 / DNA damage-binding protein 2 / Q92466* / Q99J79* / damage specific DNA binding protein 2*  / complex
 ENSGALG00000008931 COMMD1 / copper metabolism domain containing 1 / Q8K4M5* / Q8N668* / Gm28048* / COMM domain-containing protein 1 *  / complex
 ENSGALG00000014732 ERCC8 / ERCC excision repair 8, CSA ubiquitin ligase complex subunit / Q13216* / Q8CFD5* / DNA excision repair protein ERCC-8 *  / complex






 

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