ENSGALG00000042333


Gallus gallus

Features
Gene ID: ENSGALG00000042333
  
Biological name :DDB1
  
Synonyms : DDB1 / DNA damage-binding protein 1 / Q805F9
  
Possible biological names infered from orthology : damage specific DNA binding protein 1 / Q16531 / Q3U1J4
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 49831
Gene end: 63871
  
Corresponding Affymetrix probe sets: Gga.12977.1.S1_at (Chicken Array)   Gga.12977.1.S1_s_at (Chicken Array)   Gga.5146.1.S1_at (Chicken Array)   Gga.5146.1.S1_s_at (Chicken Array)   GgaAffx.11882.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000058261
Ensembl peptide - ENSGALP00000050113
NCBI entrez gene - 374050     See in Manteia.
RefSeq - NM_204216
RefSeq Peptide - NP_989547
swissprot - Q805F9
swissprot - A0A1D5PBI5
Ensembl - ENSGALG00000042333
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddb1ENSDARG00000074431Danio rerio
 DDB1ENSG00000167986Homo sapiens
 Ddb1ENSMUSG00000024740Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SF3B3* / Q15393* / Q921M3* / splicing factor 3b subunit 3*ENSGALG0000000253123


Protein motifs (from Interpro)
Interpro ID Name
 IPR004871  Cleavage/polyadenylation specificity factor, A subunit, C-terminal
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair IBA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010498 proteasomal protein catabolic process IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0035518 histone H2A monoubiquitination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0046726 positive regulation by virus of viral protein levels in host cell IEA
 biological_processGO:0051702 interaction with symbiont IEA
 biological_processGO:0070914 UV-damage excision repair IEA
 biological_processGO:1901990 regulation of mitotic cell cycle phase transition IEA
 biological_processGO:1902188 positive regulation of viral release from host cell IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IBA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IEA
 cellular_componentGO:0031465 Cul4B-RING E3 ubiquitin ligase complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0071987 WD40-repeat domain binding IEA
 molecular_functionGO:0097602 cullin family protein binding IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Nucleotide Excision Repair
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008559 CUL4B / cullin 4B / A2A432* / Q13620*  / complex
 ENSGALG00000006254 ERCC6 / ERCC excision repair 6, chromatin remodeling factor / P0DP91* / Q03468* / Q8N328*  / complex / reaction
 ENSGALG00000006357 XPC / XPC complex subunit, DNA damage recognition and repair factor / P51612* / Q01831* / xeroderma pigmentosum, complementation group C*  / complex / reaction
 ENSGALG00000008218 DDB2 / Q5ZJL7 / DNA damage-binding protein 2 / Q92466* / Q99J79* / damage specific DNA binding protein 2*  / complex
 ENSGALG00000007510 CETN2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / reaction / complex
 ENSGALG00000008931 COMMD1 / copper metabolism domain containing 1 / Q8K4M5* / Q8N668* / Gm28048* / COMM domain-containing protein 1 *  / complex
 ENSGALG00000014732 ERCC8 / ERCC excision repair 8, CSA ubiquitin ligase complex subunit / Q13216* / Q8CFD5* / DNA excision repair protein ERCC-8 *  / complex
 ENSGALG00000009837 DTL / Q5ZJW8 / Denticleless protein homolog / Q3TLR7* / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*  / complex
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / reaction / complex
 ENSGALG00000009228 PARP1 / poly / P09874* / poly(ADP-ribose) polymerase 1* / poly (ADP-ribose) polymerase family, member 1*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / reaction / complex
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / reaction / complex






 

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