ENSDARG00000074431


Danio rerio

Features
Gene ID: ENSDARG00000074431
  
Biological name :ddb1
  
Synonyms : damage-specific DNA binding protein 1 / ddb1
  
Possible biological names infered from orthology : DNA damage-binding protein 1 / Q16531 / Q3U1J4
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 50826764
Gene end: 50839033
  
Corresponding Affymetrix probe sets: Dr.4371.1.A1_at (Zebrafish Array)   Dr.4371.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000130126
swissprot - A0A0G2KCW6
ZFIN ID - ZDB-GENE-040426-1272
Ensembl - ENSDARG00000074431
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DDB1ENSGALG00000042333Gallus gallus
 DDB1ENSG00000167986Homo sapiens
 Ddb1ENSMUSG00000024740Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sf3b3 / Q1LVE8 / splicing factor 3b, subunit 3 / Q15393* / Q921M3*ENSDARG0000010355322


Protein motifs (from Interpro)
Interpro ID Name
 IPR004871  Cleavage/polyadenylation specificity factor, A subunit, C-terminal
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR031297  DNA damage-binding protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair IBA
 biological_processGO:0010564 regulation of cell cycle process IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IBA
 molecular_functionGO:0003684 damaged DNA binding IBA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
brain proliferative region decreased amount , abnormal
Show

 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
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 ZFA:0000100 cerebellum cerebellum apoptotic process increased occurrence , abnormal
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 ZFA:0000107 eye eye cell death increased occurrence , abnormal
eye decreased size , abnormal
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 ZFA:0000109 forebrain forebrain cell death increased occurrence , abnormal
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 ZFA:0000128 midbrain midbrain cell death increased occurrence , abnormal
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 ZFA:0000152 retina retina dopaminergic neuron decreased amount , abnormal
retina cell death increased occurrence , abnormal
retina decreased size , abnormal
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 ZFA:0000418 pretectum pretectum dopaminergic neuron decreased amount , abnormal
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 ZFA:0000445 optic tectum optic tectum cell death increased occurrence , abnormal
optic tectum apoptotic process increased occurrence , abnormal
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 ZFA:0001094 whole organism whole organism dead , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head flattened , abnormal
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 ZFA:0001289 ciliary marginal zone ciliary marginal zone apoptotic process increased occurrence , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage decreased size , abnormal
cranial cartilage hypoplastic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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