ENSGALG00000003922


Gallus gallus

Features
Gene ID: ENSGALG00000003922
  
Biological name :TOP2A
  
Synonyms : DNA topoisomerase 2-alpha / TOP2A
  
Possible biological names infered from orthology : DNA topoisomerase II alpha / P11388 / Q01320
  
Species: Gallus gallus
  
Chr. number: 27
Strand: -1
Band:
Gene start: 4838538
Gene end: 4857184
  
Corresponding Affymetrix probe sets: Gga.2010.1.S1_at (Chicken Array)   Gga.2010.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000039270
Ensembl peptide - ENSGALP00000052941
Ensembl peptide - ENSGALP00000049348
Ensembl peptide - ENSGALP00000046626
NCBI entrez gene - 395570     See in Manteia.
RefSeq - NM_204791
RefSeq Peptide - NP_990122
swissprot - A0A1D5PJE8
swissprot - A0A1D5P9E6
swissprot - A0A1D5P1T6
swissprot - F1NZF0
Ensembl - ENSGALG00000003922
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top2aENSDARG00000024488Danio rerio
 TOP2AENSG00000131747Homo sapiens
 Top2aENSMUSG00000020914Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TOP2B / DNA topoisomerase 2-beta / Q02880* / Q64511* / DNA topoisomerase II beta*ENSGALG0000001130066


Protein motifs (from Interpro)
Interpro ID Name
 IPR001154  DNA topoisomerase II, eukaryotic-type
 IPR001241  DNA topoisomerase, type IIA
 IPR002205  DNA topoisomerase, type IIA, subunit A/C-terminal
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR006171  TOPRIM domain
 IPR012542  DTHCT
 IPR013506  DNA topoisomerase, type IIA, subunit B, domain 2
 IPR013757  Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
 IPR013758  DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
 IPR013759  DNA topoisomerase, type IIA, subunit B, C-terminal
 IPR013760  DNA topoisomerase, type IIA-like domain superfamily
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR018522  DNA topoisomerase, type IIA, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR031660  C-terminal associated domain of TOPRIM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006265 DNA topological change IEA
 biological_processGO:0006266 DNA ligation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0030261 chromosome condensation IEA
 biological_processGO:0030263 apoptotic chromosome condensation IEA
 biological_processGO:0040016 embryonic cleavage IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1905463 negative regulation of DNA duplex unwinding IEA
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0009330 DNA topoisomerase complex (ATP-hydrolyzing) IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008301 DNA binding, bending IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / reaction






 

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