ENSGALG00000011300


Gallus gallus

Features
Gene ID: ENSGALG00000011300
  
Biological name :TOP2B
  
Synonyms : DNA topoisomerase 2-beta / TOP2B
  
Possible biological names infered from orthology : DNA topoisomerase II beta / Q02880 / Q64511
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 37979550
Gene end: 38041303
  
Corresponding Affymetrix probe sets: Gga.1331.1.S1_at (Chicken Array)   Gga.1331.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018410
NCBI entrez gene - 395966     See in Manteia.
RefSeq - XM_015281302
RefSeq - NM_205082
RefSeq - XM_015281300
RefSeq - XM_015281301
RefSeq Peptide - NP_990413
swissprot - E1BZ19
Ensembl - ENSGALG00000011300
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top2bENSDARG00000034195Danio rerio
 TOP2BENSG00000077097Homo sapiens
 Top2bENSMUSG00000017485Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TOP2A / DNA topoisomerase 2-alpha / P11388* / Q01320* / DNA topoisomerase II alpha*ENSGALG0000000392265


Protein motifs (from Interpro)
Interpro ID Name
 IPR001154  DNA topoisomerase II, eukaryotic-type
 IPR001241  DNA topoisomerase, type IIA
 IPR002205  DNA topoisomerase, type IIA, subunit A/C-terminal
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR006171  TOPRIM domain
 IPR012542  DTHCT
 IPR013506  DNA topoisomerase, type IIA, subunit B, domain 2
 IPR013757  Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
 IPR013758  DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
 IPR013759  DNA topoisomerase, type IIA, subunit B, C-terminal
 IPR013760  DNA topoisomerase, type IIA-like domain superfamily
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR018522  DNA topoisomerase, type IIA, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR031660  C-terminal associated domain of TOPRIM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006265 DNA topological change IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0030900 forebrain development IEA
 cellular_componentGO:0000792 heterochromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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