ENSMUSG00000017485


Mus musculus

Features
Gene ID: ENSMUSG00000017485
  
Biological name :Top2b
  
Synonyms : DNA topoisomerase 2-beta / Q64511 / Top2b
  
Possible biological names infered from orthology : DNA topoisomerase II beta / Q02880
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A2
Gene start: 16365179
Gene end: 16435462
  
Corresponding Affymetrix probe sets: 10412844 (MoGene1.0st)   1416731_at (Mouse Genome 430 2.0 Array)   1416732_at (Mouse Genome 430 2.0 Array)   1448458_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124889
Ensembl peptide - ENSMUSP00000017629
Ensembl peptide - ENSMUSP00000123992
NCBI entrez gene - 21974     See in Manteia.
MGI - MGI:98791
RefSeq - NM_009409
RefSeq Peptide - NP_033435
swissprot - Q64511
swissprot - F6U5K2
swissprot - F6XX57
Ensembl - ENSMUSG00000017485
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top2bENSDARG00000034195Danio rerio
 TOP2BENSGALG00000011300Gallus gallus
 TOP2BENSG00000077097Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Top2a / Q01320 / DNA topoisomerase 2-alpha / P11388* / DNA topoisomerase II alpha*ENSMUSG0000002091465


Protein motifs (from Interpro)
Interpro ID Name
 IPR001154  DNA topoisomerase II, eukaryotic-type
 IPR001241  DNA topoisomerase, type IIA
 IPR002205  DNA topoisomerase, type IIA, subunit A/C-terminal
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR006171  TOPRIM domain
 IPR012542  DTHCT
 IPR013506  DNA topoisomerase, type IIA, subunit B, domain 2
 IPR013757  Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
 IPR013758  DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
 IPR013759  DNA topoisomerase, type IIA, subunit B, C-terminal
 IPR013760  DNA topoisomerase, type IIA-like domain superfamily
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR018522  DNA topoisomerase, type IIA, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR031660  C-terminal associated domain of TOPRIM
 IPR034157  DNA topoisomerase 2, TOPRIM domain
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0000819 sister chromatid segregation IBA
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006265 DNA topological change IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0044774 mitotic DNA integrity checkpoint IBA
 cellular_componentGO:0000792 heterochromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity ISS
 molecular_functionGO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0008285 abnormal hippocampus granule cell layer 
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Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0008442 disorganized cortical plate "derangement of the patterned arrangement of the cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0008443 absent subplate "absence of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8210173]
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Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex






 

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