ENSG00000077097


Homo sapiens

Features
Gene ID: ENSG00000077097
  
Biological name :TOP2B
  
Synonyms : DNA topoisomerase II beta / Q02880 / TOP2B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p24.2
Gene start: 25597905
Gene end: 25664907
  
Corresponding Affymetrix probe sets: 211987_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396704
Ensembl peptide - ENSP00000264331
Ensembl peptide - ENSP00000388216
Ensembl peptide - ENSP00000391112
NCBI entrez gene - 7155     See in Manteia.
OMIM - 126431
RefSeq - XM_011534057
RefSeq - NM_001068
RefSeq - NM_001330700
RefSeq - XM_005265427
RefSeq Peptide - NP_001059
RefSeq Peptide - NP_001317629
swissprot - H7BZ82
swissprot - Q02880
swissprot - E9PCY5
Ensembl - ENSG00000077097
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top2bENSDARG00000034195Danio rerio
 TOP2BENSGALG00000011300Gallus gallus
 Top2bENSMUSG00000017485Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TOP2A / P11388 / DNA topoisomerase II alphaENSG0000013174765


Protein motifs (from Interpro)
Interpro ID Name
 IPR001154  DNA topoisomerase II, eukaryotic-type
 IPR001241  DNA topoisomerase, type IIA
 IPR002205  DNA topoisomerase, type IIA, subunit A/C-terminal
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR006171  TOPRIM domain
 IPR012542  DTHCT
 IPR013506  DNA topoisomerase, type IIA, subunit B, domain 2
 IPR013757  Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
 IPR013758  DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
 IPR013759  DNA topoisomerase, type IIA, subunit B, C-terminal
 IPR013760  DNA topoisomerase, type IIA-like domain superfamily
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR018522  DNA topoisomerase, type IIA, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR031660  C-terminal associated domain of TOPRIM
 IPR034157  DNA topoisomerase 2, TOPRIM domain
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0000819 sister chromatid segregation IBA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006265 DNA topological change IDA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0044774 mitotic DNA integrity checkpoint IBA
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity IDA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043021 ribonucleoprotein complex binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction






 

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