ENSDARG00000034195


Danio rerio

Features
Gene ID: ENSDARG00000034195
  
Biological name :top2b
  
Synonyms : DNA topoisomerase II beta / top2b
  
Possible biological names infered from orthology : DNA topoisomerase 2-beta / Q02880 / Q64511
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 17688350
Gene end: 17774884
  
Corresponding Affymetrix probe sets: Dr.17989.1.A1_at (Zebrafish Array)   Dr.17989.2.S1_at (Zebrafish Array)   Dr.23837.1.A1_s_at (Zebrafish Array)   DrAffx.2.79.A1_at (Zebrafish Array)   DrAffx.2.79.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000108088
Ensembl peptide - ENSDARP00000126193
NCBI entrez gene - 569877     See in Manteia.
RefSeq - XM_005159507
RefSeq Peptide - NP_001038656
swissprot - Q1LUT2
swissprot - I3ITD0
ZFIN ID - ZDB-GENE-041008-136
Ensembl - ENSDARG00000034195
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TOP2BENSGALG00000011300Gallus gallus
 TOP2BENSG00000077097Homo sapiens
 Top2bENSMUSG00000017485Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
top2a / DNA topoisomerase II alpha / P11388* / Q01320* / DNA topoisomerase 2-alpha *ENSDARG0000002448863


Protein motifs (from Interpro)
Interpro ID Name
 IPR001154  DNA topoisomerase II, eukaryotic-type
 IPR001241  DNA topoisomerase, type IIA
 IPR002205  DNA topoisomerase, type IIA, subunit A/C-terminal
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR006171  TOPRIM domain
 IPR012542  DTHCT
 IPR013506  DNA topoisomerase, type IIA, subunit B, domain 2
 IPR013757  Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
 IPR013758  DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
 IPR013759  DNA topoisomerase, type IIA, subunit B, C-terminal
 IPR013760  DNA topoisomerase, type IIA-like domain superfamily
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR018522  DNA topoisomerase, type IIA, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR031660  C-terminal associated domain of TOPRIM
 IPR034157  DNA topoisomerase 2, TOPRIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0000819 sister chromatid segregation IBA
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006265 DNA topological change IEA
 biological_processGO:0007412 axon target recognition IMP
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0044774 mitotic DNA integrity checkpoint IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000445 optic tectum optic tectum neuron projection mislocalised , abnormal
optic tectum neuron projection disorganized , abnormal
Show

 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer deformed , abnormal
Show

 ZFA:0001347 stratum fibrosum et griseum superficiale stratum fibrosum et griseum superficiale increased width , abnormal
stratum fibrosum et griseum superficiale axon mislocalised , abnormal
Show

 ZFA:0009255 amacrine cell amacrine cell neuron projection morphology , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell dendrite morphology , abnormal
Show

 ZFA:0009318 retinal bipolar neuron retinal bipolar neuron axon morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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