ENSMUSG00000020914


Mus musculus

Features
Gene ID: ENSMUSG00000020914
  
Biological name :Top2a
  
Synonyms : DNA topoisomerase 2-alpha / Q01320 / Top2a
  
Possible biological names infered from orthology : DNA topoisomerase II alpha / P11388
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 98992943
Gene end: 99024189
  
Corresponding Affymetrix probe sets: 10390707 (MoGene1.0st)   10390746 (MoGene1.0st)   10394731 (MoGene1.0st)   10408329 (MoGene1.0st)   1427724_at (Mouse Genome 430 2.0 Array)   1442454_at (Mouse Genome 430 2.0 Array)   1454694_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068896
NCBI entrez gene - 21973     See in Manteia.
MGI - MGI:98790
RefSeq - XM_006533155
RefSeq - NM_011623
RefSeq - XM_006533153
RefSeq - XM_006533154
RefSeq Peptide - NP_035753
swissprot - Q01320
Ensembl - ENSMUSG00000020914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top2aENSDARG00000024488Danio rerio
 TOP2AENSGALG00000003922Gallus gallus
 TOP2AENSG00000131747Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Top2b / Q64511 / DNA topoisomerase 2-beta / Q02880* / DNA topoisomerase II beta*ENSMUSG0000001748569


Protein motifs (from Interpro)
Interpro ID Name
 IPR001154  DNA topoisomerase II, eukaryotic-type
 IPR001241  DNA topoisomerase, type IIA
 IPR002205  DNA topoisomerase, type IIA, subunit A/C-terminal
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR006171  TOPRIM domain
 IPR012542  DTHCT
 IPR013506  DNA topoisomerase, type IIA, subunit B, domain 2
 IPR013757  Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
 IPR013758  DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
 IPR013759  DNA topoisomerase, type IIA, subunit B, C-terminal
 IPR013760  DNA topoisomerase, type IIA-like domain superfamily
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR018522  DNA topoisomerase, type IIA, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR031660  C-terminal associated domain of TOPRIM
 IPR034157  DNA topoisomerase 2, TOPRIM domain
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0000819 sister chromatid segregation IBA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006265 DNA topological change ISO
 biological_processGO:0006266 DNA ligation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0030261 chromosome condensation IMP
 biological_processGO:0030263 apoptotic chromosome condensation IEA
 biological_processGO:0040016 embryonic cleavage IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0044774 mitotic DNA integrity checkpoint IBA
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:1905463 negative regulation of DNA duplex unwinding IEA
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000793 condensed chromosome IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0009330 DNA topoisomerase complex (ATP-hydrolyzing) IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity ISO
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008301 DNA binding, bending IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr