21973


Mus musculus (NCBI)

Features
Gene ID: 21973
  
Biological name :
  
Synonyms : Top-2 / Top2a / topoisomerase (DNA) II alpha
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1427724_at (Mouse Genome 430 2.0 Array)   1442454_at (Mouse Genome 430 2.0 Array)   1454694_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - XP_006533218.1
RefSeq - 568973595
RefSeq - 568973597
RefSeq - 568973599
RefSeq - NC_000077.6
RefSeq - NP_035753.2
RefSeq - XP_006533216.1
RefSeq - XP_006533217.1
RefSeq - 153945749
RefSeq - NM_011623.2
RefSeq - XM_006533155.2
RefSeq - XM_006533153.2
RefSeq - XM_006533154.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000020914 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0000819 sister chromatid segregation IBA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006265 DNA topological change ISO
 biological_processGO:0006266 DNA ligation ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0007143 female meiotic nuclear division IMP
 biological_processGO:0030261 chromosome condensation IMP
 biological_processGO:0030263 apoptotic chromosome condensation ISO
 biological_processGO:0040016 embryonic cleavage IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0044774 mitotic DNA integrity checkpoint IBA
 biological_processGO:0045070 positive regulation of viral genome replication ISO
 biological_processGO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051309 female meiosis chromosome separation TAS
 biological_processGO:1905463 negative regulation of DNA duplex unwinding ISO
 cellular_componentGO:0000228 nuclear chromosome ISO
 cellular_componentGO:0000793 condensed chromosome IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005814 centriole ISO
 cellular_componentGO:0009330 DNA topoisomerase complex (ATP-hydrolyzing) ISO
 cellular_componentGO:0032991 protein-containing complex ISO
 cellular_componentGO:1990904 ribonucleoprotein complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0003916 DNA topoisomerase activity ISO
 molecular_functionGO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity ISO
 molecular_functionGO:0005080 protein kinase C binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008094 DNA-dependent ATPase activity ISO
 molecular_functionGO:0008144 drug binding ISO
 molecular_functionGO:0008301 DNA binding, bending ISO
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0042826 histone deacetylase binding ISO
 molecular_functionGO:0043130 ubiquitin binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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