ENSGALG00000041267


Gallus gallus

Features
Gene ID: ENSGALG00000041267
  
Biological name :BMI1
  
Synonyms : BMI1 / Polycomb complex protein BMI-1 / Q5SDR3
  
Possible biological names infered from orthology : BMI1 proto-oncogene, polycomb ring finger / COMMD3-BMI1 / COMMD3-BMI1 readthrough / P25916 / P35226
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 17748562
Gene end: 17758699
  
Corresponding Affymetrix probe sets: Gga.6243.1.S1_at (Chicken Array)   Gga.6376.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047015
Ensembl peptide - ENSGALP00000051910
NCBI entrez gene - 493647     See in Manteia.
RefSeq - NM_001007988
RefSeq Peptide - NP_001007989
swissprot - Q5SDR3
Ensembl - ENSGALG00000041267
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmi1aENSDARG00000006010Danio rerio
 bmi1bENSDARG00000013076Danio rerio
 BMI1ENSG00000168283Homo sapiens
 COMMD3-BMI1ENSG00000269897Homo sapiens
 Bmi1ENSMUSG00000026739Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PCGF2 / P23798* / P35227* / polycomb group ring finger 2* / Polycomb group RING finger protein 2 *ENSGALG0000001881562
PCGF2* / P23798* / P35227* / polycomb group ring finger 2* / Polycomb group RING finger protein 2 *ENSGALG0000004050161
PCGF6 / polycomb group ring finger 6 / Q99NA9* / Q9BYE7* / Polycomb group RING finger protein 6 *ENSGALG0000000823025
PCGF3 / polycomb group ring finger 3 / Q3KNV8* / Q8BTQ0* / Polycomb group RING finger protein 3 *ENSGALG0000001533325
PCGF5 / polycomb group ring finger 5 / Q3UK78* / Q86SE9* / Polycomb group RING finger protein 5 *ENSGALG0000000650223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR032443  RAWUL domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006306 DNA methylation IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006959 humoral immune response IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0016574 histone ubiquitination IEA
 biological_processGO:0021903 rostrocaudal neural tube patterning IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0033092 positive regulation of immature T cell proliferation in thymus IEA
 biological_processGO:0036353 histone H2A-K119 monoubiquitination ISS
 biological_processGO:0045814 negative regulation of gene expression, epigenetic ISS
 biological_processGO:0048103 somatic stem cell division IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity ISS
 biological_processGO:2000011 regulation of adaxial/abaxial pattern formation IEA
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0000151 ubiquitin ligase complex ISS
 cellular_componentGO:0000792 heterochromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031519 PcG protein complex ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding ISS


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex
 ENSGALG00000014263 PHC1 / polyhomeotic-like protein 1 / P78364* / polyhomeotic homolog 1* / Mus musculus polyhomeotic 1 (Phc1), transcript variant 5, mRNA.*  / complex
 ENSGALG00000009372 PHC3* / Q8CHP6* / Q8NDX5* / polyhomeotic homolog 3* / Polyhomeotic-like protein 3 *  / complex






 

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