ENSGALG00000036214


Gallus gallus

Features
Gene ID: ENSGALG00000036214
  
Biological name :PARK7
  
Synonyms : PARK7 / protein/nucleic acid deglycase DJ-1
  
Possible biological names infered from orthology : Parkinsonism associated deglycase / Q99497 / Q99LX0
  
Species: Gallus gallus
  
Chr. number: 21
Strand: -1
Band:
Gene start: 245686
Gene end: 252851
  
Corresponding Affymetrix probe sets: Gga.3836.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048532
Ensembl peptide - ENSGALP00000063513
Ensembl peptide - ENSGALP00000060130
Ensembl peptide - ENSGALP00000054278
NCBI entrez gene - 395277     See in Manteia.
RefSeq - NM_204585
RefSeq - XM_015296819
RefSeq Peptide - NP_989916
swissprot - D5M8S2
swissprot - A0A1L1RXD5
swissprot - A0A1D5PN39
Ensembl - ENSGALG00000036214
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 park7ENSDARG00000116835Danio rerio
 PARK7ENSG00000116288Homo sapiens
 Park7ENSMUSG00000028964Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002818  DJ-1/PfpI
 IPR006287  Protein/nucleic acid deglycase DJ-1
 IPR029062  Class I glutamine amidotransferase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001963 synaptic transmission, dopaminergic IEA
 biological_processGO:0002866 positive regulation of acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006517 protein deglycosylation IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009438 methylglyoxal metabolic process IEA
 biological_processGO:0010273 detoxification of copper ion IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0018323 enzyme active site formation via L-cysteine sulfinic acid IEA
 biological_processGO:0019249 lactate biosynthetic process IEA
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033234 negative regulation of protein sumoylation IEA
 biological_processGO:0033864 positive regulation of NAD(P)H oxidase activity IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0036471 cellular response to glyoxal IEA
 biological_processGO:0036526 peptidyl-cysteine deglycation IEA
 biological_processGO:0036527 peptidyl-arginine deglycation IEA
 biological_processGO:0036528 peptidyl-lysine deglycation IEA
 biological_processGO:0036529 protein deglycation, glyoxal removal IEA
 biological_processGO:0036530 protein deglycation, methylglyoxal removal IEA
 biological_processGO:0036531 glutathione deglycation IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042743 hydrogen peroxide metabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046295 glycolate biosynthetic process IEA
 biological_processGO:0046826 negative regulation of protein export from nucleus IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050787 detoxification of mercury ion IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051444 negative regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0051583 dopamine uptake involved in synaptic transmission IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0060081 membrane hyperpolarization IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0060765 regulation of androgen receptor signaling pathway IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0090073 positive regulation of protein homodimerization activity IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:0106044 guanine deglycation IEA
 biological_processGO:0106045 guanine deglycation, methylglyoxal removal IEA
 biological_processGO:0106046 guanine deglycation, glyoxal removal IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901671 positive regulation of superoxide dismutase activity IEA
 biological_processGO:1901984 negative regulation of protein acetylation IEA
 biological_processGO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone IEA
 biological_processGO:1903094 negative regulation of protein K48-linked deubiquitination IEA
 biological_processGO:1903122 negative regulation of TRAIL-activated apoptotic signaling pathway IEA
 biological_processGO:1903168 positive regulation of pyrroline-5-carboxylate reductase activity IEA
 biological_processGO:1903178 positive regulation of tyrosine 3-monooxygenase activity IEA
 biological_processGO:1903181 positive regulation of dopamine biosynthetic process IEA
 biological_processGO:1903189 glyoxal metabolic process IEA
 biological_processGO:1903197 positive regulation of L-dopa biosynthetic process IEA
 biological_processGO:1903200 positive regulation of L-dopa decarboxylase activity IEA
 biological_processGO:1903202 negative regulation of oxidative stress-induced cell death IEA
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death IEA
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death IEA
 biological_processGO:1903208 negative regulation of hydrogen peroxide-induced neuron death IEA
 biological_processGO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903427 negative regulation of reactive oxygen species biosynthetic process IEA
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process IEA
 biological_processGO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:2000157 negative regulation of ubiquitin-specific protease activity IEA
 biological_processGO:2000277 positive regulation of oxidative phosphorylation uncoupler activity IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2000825 positive regulation of androgen receptor activity IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005747 mitochondrial respiratory chain complex I IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016532 superoxide dismutase copper chaperone activity IEA
 molecular_functionGO:0016684 oxidoreductase activity, acting on peroxide as acceptor IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019955 cytokine binding IEA
 molecular_functionGO:0036470 tyrosine 3-monooxygenase activator activity IEA
 molecular_functionGO:0036478 L-dopa decarboxylase activator activity IEA
 molecular_functionGO:0036524 protein deglycase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044388 small protein activating enzyme binding IEA
 molecular_functionGO:0044390 ubiquitin-like protein conjugating enzyme binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0045340 mercury ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding IEA
 molecular_functionGO:0051920 peroxiredoxin activity IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA
 molecular_functionGO:1903135 cupric ion binding IEA
 molecular_functionGO:1903136 cuprous ion binding IEA
 molecular_functionGO:1990381 ubiquitin-specific protease binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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