ENSMUSG00000028964


Mus musculus

Features
Gene ID: ENSMUSG00000028964
  
Biological name :Park7
  
Synonyms : Park7 / Protein/nucleic acid deglycase DJ-1 / Q99LX0
  
Possible biological names infered from orthology : Parkinsonism associated deglycase / Q99497
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 150897133
Gene end: 150914437
  
Corresponding Affymetrix probe sets: 10518774 (MoGene1.0st)   1416526_a_at (Mouse Genome 430 2.0 Array)   1456194_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101300
Ensembl peptide - ENSMUSP00000122265
Ensembl peptide - ENSMUSP00000120832
Ensembl peptide - ENSMUSP00000115875
Ensembl peptide - ENSMUSP00000101301
Ensembl peptide - ENSMUSP00000030805
Ensembl peptide - ENSMUSP00000101298
Ensembl peptide - ENSMUSP00000101299
NCBI entrez gene - 57320     See in Manteia.
MGI - MGI:2135637
RefSeq - NM_020569
RefSeq Peptide - NP_065594
swissprot - A2A813
swissprot - A2A817
swissprot - Q99LX0
swissprot - A2A816
swissprot - A2A815
Ensembl - ENSMUSG00000028964
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 park7ENSDARG00000116835Danio rerio
 PARK7ENSGALG00000036214Gallus gallus
 PARK7ENSG00000116288Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002818  DJ-1/PfpI
 IPR006287  Protein/nucleic acid deglycase DJ-1
 IPR029062  Class I glutamine amidotransferase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation ISO
 biological_processGO:0001963 synaptic transmission, dopaminergic IMP
 biological_processGO:0002866 positive regulation of acute inflammatory response to antigenic stimulus IMP
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006469 negative regulation of protein kinase activity ISO
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006517 protein deglycosylation ISS
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0010273 detoxification of copper ion ISS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0018323 enzyme active site formation via L-cysteine sulfinic acid IMP
 biological_processGO:0019249 lactate biosynthetic process ISO
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0032091 negative regulation of protein binding ISS
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0032757 positive regulation of interleukin-8 production ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0033234 negative regulation of protein sumoylation ISO
 biological_processGO:0033864 positive regulation of NAD(P)H oxidase activity IMP
 biological_processGO:0034599 cellular response to oxidative stress ISO
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0036471 cellular response to glyoxal IMP
 biological_processGO:0036526 peptidyl-cysteine deglycation ISO
 biological_processGO:0036527 peptidyl-arginine deglycation ISO
 biological_processGO:0036528 peptidyl-lysine deglycation ISO
 biological_processGO:0036529 protein deglycation, glyoxal removal ISO
 biological_processGO:0036531 glutathione deglycation ISO
 biological_processGO:0042177 negative regulation of protein catabolic process IMP
 biological_processGO:0042542 response to hydrogen peroxide IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0042743 hydrogen peroxide metabolic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043523 regulation of neuron apoptotic process ISO
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046295 glycolate biosynthetic process IDA
 biological_processGO:0046826 negative regulation of protein export from nucleus ISO
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050787 detoxification of mercury ion ISO
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051444 negative regulation of ubiquitin-protein transferase activity IC
 biological_processGO:0051583 dopamine uptake involved in synaptic transmission IMP
 biological_processGO:0051881 regulation of mitochondrial membrane potential ISO
 biological_processGO:0051899 membrane depolarization IMP
 biological_processGO:0060081 membrane hyperpolarization IMP
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0060765 regulation of androgen receptor signaling pathway ISO
 biological_processGO:0070301 cellular response to hydrogen peroxide ISO
 biological_processGO:0090073 positive regulation of protein homodimerization activity ISO
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:0106044 guanine deglycation ISO
 biological_processGO:0106045 guanine deglycation, methylglyoxal removal ISO
 biological_processGO:0106046 guanine deglycation, glyoxal removal ISO
 biological_processGO:1900182 positive regulation of protein localization to nucleus ISO
 biological_processGO:1901215 negative regulation of neuron death ISO
 biological_processGO:1901671 positive regulation of superoxide dismutase activity ISO
 biological_processGO:1901984 negative regulation of protein acetylation ISO
 biological_processGO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone IMP
 biological_processGO:1903094 negative regulation of protein K48-linked deubiquitination ISO
 biological_processGO:1903122 negative regulation of TRAIL-activated apoptotic signaling pathway ISO
 biological_processGO:1903168 positive regulation of pyrroline-5-carboxylate reductase activity ISO
 biological_processGO:1903178 positive regulation of tyrosine 3-monooxygenase activity ISO
 biological_processGO:1903181 positive regulation of dopamine biosynthetic process ISO
 biological_processGO:1903189 glyoxal metabolic process IDA
 biological_processGO:1903197 positive regulation of L-dopa biosynthetic process ISO
 biological_processGO:1903200 positive regulation of L-dopa decarboxylase activity ISO
 biological_processGO:1903202 negative regulation of oxidative stress-induced cell death ISO
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death IMP
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death ISO
 biological_processGO:1903208 negative regulation of hydrogen peroxide-induced neuron death IMP
 biological_processGO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
 biological_processGO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903427 negative regulation of reactive oxygen species biosynthetic process IMP
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process IDA
 biological_processGO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway ISO
 biological_processGO:2000157 negative regulation of ubiquitin-specific protease activity ISO
 biological_processGO:2000277 positive regulation of oxidative phosphorylation uncoupler activity IMP
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding ISO
 biological_processGO:2000825 positive regulation of androgen receptor activity ISO
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway ISO
 biological_processGO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
 cellular_componentGO:0000785 chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005747 mitochondrial respiratory chain complex I ISO
 cellular_componentGO:0005758 mitochondrial intermembrane space IDA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016605 PML body ISO
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003729 mRNA binding ISS
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005507 copper ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0016532 superoxide dismutase copper chaperone activity ISO
 molecular_functionGO:0016684 oxidoreductase activity, acting on peroxide as acceptor ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019900 kinase binding ISO
 molecular_functionGO:0019955 cytokine binding ISO
 molecular_functionGO:0036470 tyrosine 3-monooxygenase activator activity ISO
 molecular_functionGO:0036478 L-dopa decarboxylase activator activity ISO
 molecular_functionGO:0036524 protein deglycase activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0044388 small protein activating enzyme binding ISO
 molecular_functionGO:0044390 ubiquitin-like protein conjugating enzyme binding ISO
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0045340 mercury ion binding ISO
 molecular_functionGO:0050681 androgen receptor binding ISO
 molecular_functionGO:0051920 peroxiredoxin activity IMP
 molecular_functionGO:0070491 repressing transcription factor binding ISO
 molecular_functionGO:0097110 scaffold protein binding ISO
 molecular_functionGO:1903135 cupric ion binding ISO
 molecular_functionGO:1903136 cuprous ion binding ISO
 molecular_functionGO:1990381 ubiquitin-specific protease binding ISO


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J

Allelic Composition: Park7tm1Cai/Park7tm1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fbn1Tsk/Fbn1+
Genetic Background: B6.Cg-Fbn1Tsk +/+ Bloc1s6pa/JKcc

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Gpx1tm1Ysh Prkntm1Shn

Allelic Composition: Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Prkntm1Shn

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Park7tm1Cai/Park7tm1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Park7tm1Cai/Park7tm1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Gpx1tm1Ysh Prkntm1Shn

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

Allelic Composition: Park7tm1Xz/Park7tm1Xz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Park7tm1Cai/Park7tm1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0003444 abnormal neurotransmitter uptake "aberration in the reabsorbtion of endogenous signaling molecules normally taken in by neurons that alter the behavior of neurons or effector cells" [J:95639, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0003661 abnormal locus ceruleus "anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-icre)9190Gsc/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0008830 abnormal nucleolus morphology "any structural anomaly of the small rounded nuclear substructure that produces ribonucleoprotein" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Park7Gt(XE726)Byg/Park7Gt(XE726)Byg,Pink1tm1.1Wrst/Pink1tm1.1Wrst,Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-cre/ERT2)1Span/0
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Park7tm1Cai/Park7tm1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Gpx1tm1Ysh Prkntm1Shn

Allelic Composition: Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Prkntm1Shn

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010958 abnormal tricarboxylic acid cycle "any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD

 MP:0013219 abnormal substantia nigra pars compacta morphology "any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species" [MGI:anna]
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Allelic Composition: Cyp27b1tm1Hfd/Cyp27b1tm1Hfd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction






 

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