ENSMUSG00000000730


Mus musculus

Features
Gene ID: ENSMUSG00000000730
  
Biological name :Dnmt3l
  
Synonyms : DNA (cytosine-5)-methyltransferase 3-like / Dnmt3l / Q9CWR8
  
Possible biological names infered from orthology : DNA methyltransferase 3 like / FP565260.4 / Q9UJW3
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 78041947
Gene end: 78063622
  
Corresponding Affymetrix probe sets: 10364346 (MoGene1.0st)   1425035_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121562
Ensembl peptide - ENSMUSP00000119571
Ensembl peptide - ENSMUSP00000123015
Ensembl peptide - ENSMUSP00000000746
Ensembl peptide - ENSMUSP00000116970
Ensembl peptide - ENSMUSP00000117827
NCBI entrez gene - 54427     See in Manteia.
MGI - MGI:1859287
RefSeq - NM_001284197
RefSeq - NM_001081695
RefSeq - NM_001284198
RefSeq - NM_001284199
RefSeq - NM_001284200
RefSeq - NM_019448
RefSeq Peptide - NP_062321
RefSeq Peptide - NP_001271127
RefSeq Peptide - NP_001271128
RefSeq Peptide - NP_001271129
RefSeq Peptide - NP_001075164
RefSeq Peptide - NP_001271126
swissprot - Q9CWR8
swissprot - D3YUQ4
swissprot - A3EWM2
Ensembl - ENSMUSG00000000730
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DNMT3LENSG00000142182Homo sapiens
 FP565260.4ENSG00000279493Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*ENSMUSG0000002066133
Dnmt3b / O88509 / DNA (cytosine-5)-methyltransferase 3B / Q9UBC3* / DNA methyltransferase 3 beta*ENSMUSG0000002747832
Dnmt3c / DNMT3B* / Q9UBC3* / DNA methyltransferase 3 beta*ENSMUSG0000008207931


Protein motifs (from Interpro)
Interpro ID Name
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR025766  ADD domain
 IPR030486  DNA (cytosine-5)-methyltransferase 3-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006306 DNA methylation IEA
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010529 negative regulation of transposition IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032259 methylation IMP
 biological_processGO:0032776 DNA methylation on cytosine IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0060718 chorionic trophoblast cell differentiation IMP
 biological_processGO:0071514 genetic imprinting IMP
 biological_processGO:1905642 negative regulation of DNA methylation IMP
 biological_processGO:1905643 positive regulation of DNA methylation IMP
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity ISO
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030234 enzyme regulator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001116 small gonad "reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Dnmt3ltm1Scot/Dnmt3ltm1Scot
Genetic Background: C57BL/6-Dnmt3ltm1Scot

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dnmt3ltm1Scot/Dnmt3ltm1Scot
Genetic Background: C57BL/6-Dnmt3ltm1Scot

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0005032 abnormal ectoplacental cone 
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dnmt3ltm1Scot/Dnmt3ltm1Scot
Genetic Background: C57BL/6-Dnmt3ltm1Scot

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dnmt3ltm1Scot/Dnmt3ltm1Scot
Genetic Background: C57BL/6-Dnmt3ltm1Scot

 MP:0009397 increased trophoblast giant cell number "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Dnmt3ltm1Scot/Dnmt3ltm1Scot
Genetic Background: C57BL/6-Dnmt3ltm1Scot

 MP:0020515 abnormal visceral yolk sac endoderm morphology "any structural anomaly of the portion of the visceral yolk sac consisting of endoderm-derived cells that is responsible for absorption of nutrients" [https://discovery.lifemapsc.com/in-vivo-development/yolk-sac/yolk-sac-endoderm, PMID:20672346]
Show

Allelic Composition: Dnmt3ltm1Bes/Dnmt3ltm1Bes
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction / complex
 ENSMUSG00000000730 Dnmt3l / Q9CWR8 / DNA (cytosine-5)-methyltransferase 3-like / Q9UJW3* / FP565260.4* / DNA methyltransferase 3 like*  / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000020661 Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*  / complex
 ENSMUSG00000027478 Dnmt3b / O88509 / DNA (cytosine-5)-methyltransferase 3B / Q9UBC3* / DNA methyltransferase 3 beta*  / complex






 

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