ENSG00000142182


Homo sapiens

Features
Gene ID: ENSG00000142182
  
Biological name :DNMT3L
  
Synonyms : DNA methyltransferase 3 like / DNMT3L / Q9UJW3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.3
Gene start: 44246339
Gene end: 44262216
  
Corresponding Affymetrix probe sets: 220139_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400242
Ensembl peptide - ENSP00000486001
Ensembl peptide - ENSP00000411608
Ensembl peptide - ENSP00000270172
NCBI entrez gene - 29947     See in Manteia.
OMIM - 606588
RefSeq - NM_013369
RefSeq - NM_175867
RefSeq Peptide - NP_037501
RefSeq Peptide - NP_787063
swissprot - Q9UJW3
swissprot - H7C3F7
swissprot - C9J0T5
Ensembl - ENSG00000142182
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Dnmt3lENSMUSG00000000730Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FP565260.4ENSG0000027949340
DNMT3A / Q9Y6K1 / DNA methyltransferase 3 alphaENSG0000011977237
DNMT3B / Q9UBC3 / DNA methyltransferase 3 betaENSG0000008830535


Protein motifs (from Interpro)
Interpro ID Name
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR025766  ADD domain
 IPR030486  DNA (cytosine-5)-methyltransferase 3-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006306 DNA methylation IEA
 biological_processGO:0006349 regulation of gene expression by genetic imprinting NAS
 biological_processGO:0007141 male meiosis I ISS
 biological_processGO:0007283 spermatogenesis NAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032776 DNA methylation on cytosine ISS
 biological_processGO:0043046 DNA methylation involved in gamete generation ISS
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048863 stem cell differentiation ISS
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:1905642 negative regulation of DNA methylation ISS
 biological_processGO:1905643 positive regulation of DNA methylation ISS
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005829 cytosol HDA
 cellular_componentGO:0035098 ESC/E(Z) complex ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IDA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030234 enzyme regulator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
DNA methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088305 DNMT3B / Q9UBC3 / DNA methyltransferase 3 beta  / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction / complex
 ENSG00000119772 DNMT3A / Q9Y6K1 / DNA methyltransferase 3 alpha  / complex
 ENSG00000142182 DNMT3L / Q9UJW3 / DNA methyltransferase 3 like  / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction






 

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