ENSMUSG00000037369


Mus musculus

Features
Gene ID: ENSMUSG00000037369
  
Biological name :Kdm6a
  
Synonyms : Kdm6a / Lysine-specific demethylase 6A / O70546
  
Possible biological names infered from orthology : lysine demethylase 6A / O15550
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.2
Gene start: 18162575
Gene end: 18279936
  
Corresponding Affymetrix probe sets: 10598798 (MoGene1.0st)   1427235_at (Mouse Genome 430 2.0 Array)   1427672_a_at (Mouse Genome 430 2.0 Array)   1440524_at (Mouse Genome 430 2.0 Array)   1445198_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153167
Ensembl peptide - ENSMUSP00000061539
Ensembl peptide - ENSMUSP00000153215
Ensembl peptide - ENSMUSP00000153609
Ensembl peptide - ENSMUSP00000153267
Ensembl peptide - ENSMUSP00000045862
NCBI entrez gene - 22289     See in Manteia.
MGI - MGI:1095419
RefSeq - XM_017318461
RefSeq - NM_009483
RefSeq - XM_006527594
RefSeq - XM_006527595
RefSeq - XM_006527596
RefSeq - XM_006527597
RefSeq - XM_006527599
RefSeq - XM_006527600
RefSeq - NM_001310444
RefSeq Peptide - NP_001297373
RefSeq Peptide - NP_033509
swissprot - A0A286YD05
swissprot - A0A286YDX1
swissprot - A0A286YCW2
swissprot - O70546
swissprot - A0A286YD51
Ensembl - ENSMUSG00000037369
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm6aENSDARG00000061759Danio rerio
 ENSGALG00000016217Gallus gallus
 KDM6AENSG00000147050Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Uty / ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome / O14607* / ubiquitously transcribed tetratricopeptide repeat containing, Y-linked*ENSMUSG0000006845766
Kdm6b / Q5NCY0 / Lysine-specific demethylase 6B / O15054* / lysine demethylase 6B*ENSMUSG0000001847632


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR029516  Histone demethylase UTY


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0032525 somite rostral/caudal axis specification IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0048333 mesodermal cell differentiation IMP
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0048570 notochord morphogenesis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0071557 histone H3-K27 demethylation IEA
 biological_processGO:0072358 cardiovascular system development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0035097 histone methyltransferase complex IEA
 cellular_componentGO:0044666 MLL3/4 complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0071558 histone demethylase activity (H3-K27 specific) IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Y
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6aGt(RRA094)Byg/Y,X/UtyGt(XS0378)Wtsi
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja,Pank3tm1.1Suja/Pank3tm1.1Suja
Genetic Background: involves: 129S/SvEv

Allelic Composition: Kdm6atm1.2Afst/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Kdm6atm1.2Afst/Kdm6atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Kdm6atm1b(EUCOMM)Jae/Kdm6atm1b(EUCOMM)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Y
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6aGt(RRA094)Byg/Y,X/UtyGt(XS0378)Wtsi
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja,Pank3tm1.1Suja/Pank3tm1.1Suja
Genetic Background: involves: 129S/SvEv

Allelic Composition: Kdm6aGt(RRA094)Byg/Y
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Y
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0000919 cranioschisis "incomplete closure of the skull, usually congenital " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Kdm6atm1.2Afst/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Kdm6atm1.2Afst/Kdm6atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Kdm6atm1a(EUCOMM)Jhha/Kdm6atm1b(EUCOMM)Jhha,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Kdm6aGt(RRA094)Byg/Kdm6aGt(RRA094)Byg
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja,Pank3tm1.1Suja/Pank3tm1.1Suja
Genetic Background: involves: 129S/SvEv

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Aco1*)Mwh/Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Genetic Background: B6.129P2(129S1)-Gt(ROSA)26Sortm1.1(Aco1*)Mwh

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Sox4+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Y
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja,Pank3tm1.1Suja/Pank3tm1.1Suja
Genetic Background: involves: 129S/SvEv

Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

Allelic Composition: Kdm6atm1.2Afst/Kdm6atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Kdm6aGt(RRA094)Byg
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Kdm6aGt(RRA094)Byg
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kdm6atm1b(EUCOMM)Jae/Kdm6atm1b(EUCOMM)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Y
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6aGt(RRA094)Byg/Y,X/UtyGt(XS0378)Wtsi
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja,Pank3tm1.1Suja/Pank3tm1.1Suja
Genetic Background: involves: 129S/SvEv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Sox4+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Y
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zbtb7btm7Itan/Zbtb7btm7Itan
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zbtb7btm7Itan/Zbtb7btm7Itan
Genetic Background: Not Specified

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Y
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6aGt(RRA094)Byg/Y,X/UtyGt(XS0378)Wtsi
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja,Pank3tm1.1Suja/Pank3tm1.1Suja
Genetic Background: involves: 129S/SvEv

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Kdm6aGt(RRA094)Byg
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja,Pank3tm1.1Suja/Pank3tm1.1Suja
Genetic Background: involves: 129S/SvEv

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Kdm6atm1b(EUCOMM)Jae/Kdm6atm1b(EUCOMM)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003794 delayed somite formation "late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]
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Allelic Composition: Kdm6atm1b(EUCOMM)Jae/Kdm6atm1b(EUCOMM)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003795 abnormal bone structure 
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Kdm6atm1.2Afst/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Kdm6atm1.2Afst/Kdm6atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja,Pank3tm1.1Suja/Pank3tm1.1Suja
Genetic Background: involves: 129S/SvEv

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Kdm6atm1b(EUCOMM)Jae/Kdm6atm1b(EUCOMM)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Kdm6aGt(RRA094)Byg
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6aGt(RRA094)Byg/Y,X/UtyGt(XS0378)Wtsi
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja,Pank3tm1.1Suja/Pank3tm1.1Suja
Genetic Background: involves: 129S/SvEv

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kdm6atm1a(EUCOMM)Jhha/Kdm6atm1b(EUCOMM)Jhha,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0009397 increased trophoblast giant cell number "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6atm1b(EUCOMM)Jae/Kdm6atm1b(EUCOMM)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Kdm6atm1b(EUCOMM)Jae/Kdm6atm1b(EUCOMM)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Y
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Y
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0010503 myocardial trabeculae hypoplasia "underdevelopment or reduced size of the supporting bundles of muscular fibers lining the walls of the heart, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Kdm6aGt(RRA094)Byg
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6aGt(RRA094)Byg/Y,X/UtyGt(XS0378)Wtsi
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Kdm6aGt(RRA094)Byg
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6aGt(RRA094)Byg/Y,X/UtyGt(XS0378)Wtsi
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Kdm6aGt(RRA094)Byg/Y
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Y
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1c(EUCOMM)Wtsi/Y
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pank2tm1.1Suja/Pank2tm1.1Suja,Pank3tm1.1Suja/Pank3tm1.1Suja
Genetic Background: involves: 129S/SvEv

Allelic Composition: Kdm6atm1.2Afst/Kdm6atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Kdm6aGt(RRA094)Byg/Kdm6aGt(RRA094)Byg
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6aGt(RRA094)Byg/Y,X/UtyGt(XS0378)Wtsi
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

Allelic Composition: Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
Genetic Background: either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Kdm6atm1.2Afst/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Kdm6atm1b(EUCOMM)Jae/Kdm6atm1b(EUCOMM)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Kdm6atm1b(EUCOMM)Jae/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0012185 abnormal muscle precursor cell morphology "any structural anomaly of cells that will develop into muscle cells" [MGI:mnk]
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Allelic Composition: Atp6ap2tm1.1Ics/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Kdm6atm1.1Kaig/Y,Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kdm6atm2.1Kaig/Y
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kdm6atm2.1Kaig/Kdm6atm2.1Kaig
Genetic Background: involves: 129 * C57BL/6

 MP:0013239 impaired skeletal muscle regeneration "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Atp6ap2tm1.1Ics/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Kdm6atm1.1Kaig/Y,Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kdm6atm1.1Kaig/Y,Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kdm6atm2.1Kaig/Y
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kdm6atm2.1Kaig/Kdm6atm2.1Kaig
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex






 

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