ENSMUSG00000024513


Mus musculus

Features
Gene ID: ENSMUSG00000024513
  
Biological name :Mbd2
  
Synonyms : Mbd2 / Methyl-CpG-binding domain protein 2 / Q9Z2E1
  
Possible biological names infered from orthology : Q9UBB5
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E2
Gene start: 70568189
Gene end: 70626131
  
Corresponding Affymetrix probe sets: 10456566 (MoGene1.0st)   1417165_at (Mouse Genome 430 2.0 Array)   1425803_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073701
Ensembl peptide - ENSMUSP00000110596
Ensembl peptide - ENSMUSP00000120508
NCBI entrez gene - 17191     See in Manteia.
MGI - MGI:1333813
RefSeq - XM_006525711
RefSeq - NM_001311071
RefSeq - NM_010773
RefSeq - XM_006525710
RefSeq Peptide - NP_034903
RefSeq Peptide - NP_001298000
swissprot - Q9Z2E1
swissprot - F6UPR7
Ensembl - ENSMUSG00000024513
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mbd2ENSDARG00000075952Danio rerio
 MBD2ENSG00000134046Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mbd3 / Q9Z2D8 / Methyl-CpG-binding domain protein 3 / O95983*ENSMUSG0000003547842
Mbd3l1 / Q9D9H3 / methyl-CpG binding domain protein 3-like 1 / Q8WWY6*ENSMUSG0000003869114
Mbd3l2 / A6NE82* / A6NJ08* / Q8NHZ7* / A6NDZ8* / MBD3L3* / MBD3L4* / MBD3L5* / MBD3L2B* / A0A1B0GVZ6* / methyl-CpG binding domain protein 3 like 3* / methyl-CpG binding domain protein 3 lik...ENSMUSG0000004750811


Protein motifs (from Interpro)
Interpro ID Name
 IPR001739  Methyl-CpG DNA binding
 IPR016177  DNA-binding domain superfamily
 IPR025884  Methyl-CpG binding protein 2/3, C-terminal domain
 IPR032343  Methyl-CpG-binding domain protein 2/3, p55-binding region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006346 methylation-dependent chromatin silencing IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IGI
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0035563 positive regulation of chromatin binding IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042711 maternal behavior IMP
 biological_processGO:0044030 regulation of DNA methylation IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0000118 histone deacetylase complex IDA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008327 methyl-CpG binding ISO
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0035197 siRNA binding IDA
 molecular_functionGO:0070742 C2H2 zinc finger domain binding ISO


Pathways (from Reactome)
Pathway description
NoRC negatively regulates rRNA expression
RNA Polymerase I Promoter Opening


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: CrygeENU449/Cryge+
Genetic Background: involves: 102/El * C3H * T STOCK

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: CrygeENU449/Cryge+
Genetic Background: involves: 102/El * C3H * T STOCK

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: CrygeENU449/Cryge+
Genetic Background: involves: 102/El * C3H * T STOCK

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Mbd2tm1Bh/Mbd2tm1Bh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: ApcMin/Apc+,Mbd2tm1Bh/Mbd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbd2tm1Bh/Mbd2tm1Bh,Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Mbd2tm1Bh/Mbd2tm1Bh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Mbd2tm1Bh/Mbd2tm1Bh,Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: ApcMin/Apc+,Mbd2tm1Bh/Mbd2tm1Bh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: ApcMin/Apc+,Mbd2tm1Bh/Mbd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction






 

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