ENSG00000134046


Homo sapiens

Features
Gene ID: ENSG00000134046
  
Biological name :MBD2
  
Synonyms : MBD2 / methyl-CpG binding domain protein 2 / Q9UBB5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q21.2
Gene start: 54151601
Gene end: 54224788
  
Corresponding Affymetrix probe sets: 202484_s_at (Human Genome U133 Plus 2.0 Array)   202485_s_at (Human Genome U133 Plus 2.0 Array)   214396_s_at (Human Genome U133 Plus 2.0 Array)   214397_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464554
Ensembl peptide - ENSP00000256429
Ensembl peptide - ENSP00000381435
Ensembl peptide - ENSP00000462393
NCBI entrez gene - 8932     See in Manteia.
OMIM - 603547
RefSeq - NM_015832
RefSeq - NM_003927
RefSeq Peptide - NP_003918
RefSeq Peptide - NP_056647
swissprot - X6RBL6
swissprot - A0A024R2B8
swissprot - J3KSA7
swissprot - Q9UBB5
Ensembl - ENSG00000134046
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mbd2ENSDARG00000075952Danio rerio
 Mbd2ENSMUSG00000024513Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MBD3 / O95983 / methyl-CpG binding domain protein 3ENSG0000007165543
MBD3L1 / Q8WWY6 / methyl-CpG binding domain protein 3 like 1ENSG0000017094817
MBD3L2 / Q8NHZ7 / methyl-CpG binding domain protein 3 like 2ENSG0000023052214
A6NE82 / MBD3L3 / methyl-CpG binding domain protein 3 like 3ENSG0000018231514
A6NJ08 / MBD3L5 / methyl-CpG binding domain protein 3 like 5ENSG0000023724714
A6NDZ8 / MBD3L4 / methyl-CpG binding domain protein 3 like 4ENSG0000020571814
MBD3L2B / A0A1B0GVZ6 / methyl-CpG binding domain protein 3 like 2BENSG0000019658914


Protein motifs (from Interpro)
Interpro ID Name
 IPR001739  Methyl-CpG DNA binding
 IPR016177  DNA-binding domain superfamily
 IPR025884  Methyl-CpG binding protein 2/3, C-terminal domain
 IPR032343  Methyl-CpG-binding domain protein 2/3, p55-binding region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006346 methylation-dependent chromatin silencing IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0035563 positive regulation of chromatin binding IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042711 maternal behavior IEA
 biological_processGO:0043044 ATP-dependent chromatin remodeling HDA
 biological_processGO:0044030 regulation of DNA methylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated NAS
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0000792 heterochromatin IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0032991 protein-containing complex HDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding HDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding HDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003696 satellite DNA binding TAS
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008327 methyl-CpG binding NAS
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0031492 nucleosomal DNA binding HDA
 molecular_functionGO:0035197 siRNA binding IEA
 molecular_functionGO:0070742 C2H2 zinc finger domain binding IPI


Pathways (from Reactome)
Pathway description
NoRC negatively regulates rRNA expression
RNA Polymerase I Promoter Opening


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction / complex






 

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