ENSG00000071655


Homo sapiens

Features
Gene ID: ENSG00000071655
  
Biological name :MBD3
  
Synonyms : MBD3 / methyl-CpG binding domain protein 3 / O95983
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 1573596
Gene end: 1592801
  
Corresponding Affymetrix probe sets: 202463_s_at (Human Genome U133 Plus 2.0 Array)   222183_x_at (Human Genome U133 Plus 2.0 Array)   41160_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000412302
Ensembl peptide - ENSP00000484202
Ensembl peptide - ENSP00000482276
Ensembl peptide - ENSP00000479427
Ensembl peptide - ENSP00000477547
Ensembl peptide - ENSP00000466670
Ensembl peptide - ENSP00000464718
Ensembl peptide - ENSP00000156825
NCBI entrez gene - 53615     See in Manteia.
OMIM - 603573
RefSeq - NM_001281453
RefSeq - NM_001281454
RefSeq Peptide - NP_001268382
RefSeq Peptide - NP_001268383
swissprot - K7EIE8
swissprot - A0A0A0MTS6
swissprot - O95983
swissprot - A0A087X1H1
swissprot - A0A087WZ12
swissprot - A0A087WVG6
swissprot - A0A087WT34
Ensembl - ENSG00000071655
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mbd3aENSDARG00000061774Danio rerio
 Mbd3ENSMUSG00000035478Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MBD2 / Q9UBB5 / methyl-CpG binding domain protein 2ENSG0000013404660
MBD3L1 / Q8WWY6 / methyl-CpG binding domain protein 3 like 1ENSG0000017094829
A6NJ08 / MBD3L5 / methyl-CpG binding domain protein 3 like 5ENSG0000023724721
MBD3L2B / A0A1B0GVZ6 / methyl-CpG binding domain protein 3 like 2BENSG0000019658921
A6NE82 / MBD3L3 / methyl-CpG binding domain protein 3 like 3ENSG0000018231521
MBD3L2 / Q8NHZ7 / methyl-CpG binding domain protein 3 like 2ENSG0000023052221
A6NDZ8 / MBD3L4 / methyl-CpG binding domain protein 3 like 4ENSG0000020571821


Protein motifs (from Interpro)
Interpro ID Name
 IPR001739  Methyl-CpG DNA binding
 IPR016177  DNA-binding domain superfamily
 IPR025884  Methyl-CpG binding protein 2/3, C-terminal domain
 IPR032343  Methyl-CpG-binding domain protein 2/3, p55-binding region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006346 methylation-dependent chromatin silencing IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009888 tissue development IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0043044 ATP-dependent chromatin remodeling HDA
 biological_processGO:0044030 regulation of DNA methylation IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin HDA
 cellular_componentGO:0000792 heterochromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016581 NuRD complex IEA
 cellular_componentGO:0032991 protein-containing complex HDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding HDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding HDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004407 histone deacetylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008327 methyl-CpG binding IEA
 molecular_functionGO:0031492 nucleosomal DNA binding HDA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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