Manteia

ENSMUSG00000035478

Mus musculus

Features

Gene ID:	ENSMUSG00000035478

Biological name :	Mbd3

Synonyms :	Mbd3 / Methyl-CpG-binding domain protein 3 / Q9Z2D8

Possible biological names infered from orthology :	O95983

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	C1
Gene start:	80392539
Gene end:	80399550

Corresponding Affymetrix probe sets:	10370824 (MoGene1.0st) 1417728_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000089948 Ensembl peptide - ENSMUSP00000100985 Ensembl peptide - ENSMUSP00000100986 Ensembl peptide - ENSMUSP00000120675 Ensembl peptide - ENSMUSP00000100984 NCBI entrez gene - 17192 See in Manteia. MGI - MGI:1333812 RefSeq - XM_006513303 RefSeq - NM_001306143 RefSeq - NM_013595 RefSeq - XM_006513301 RefSeq Peptide - NP_001293072 RefSeq Peptide - NP_038623 swissprot - D3YTR4 swissprot - F6WZH1 swissprot - D3YTR5 swissprot - Q9Z2D8 Ensembl - ENSMUSG00000035478

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mbd3a	ENSDARG00000061774	Danio rerio
MBD3	ENSG00000071655	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Mbd2 / Q9Z2E1 / Methyl-CpG-binding domain protein 2 / Q9UBB5*	ENSMUSG00000024513	61
Mbd3l1 / Q9D9H3 / methyl-CpG binding domain protein 3-like 1 / Q8WWY6*	ENSMUSG00000038691	22
Mbd3l2 / A6NE82* / A6NJ08* / Q8NHZ7* / A6NDZ8* / MBD3L3* / MBD3L4* / MBD3L5* / MBD3L2B* / A0A1B0GVZ6* / methyl-CpG binding domain protein 3 like 3* / methyl-CpG binding domain protein 3 lik...	ENSMUSG00000047508	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR001739	Methyl-CpG DNA binding
IPR016177	DNA-binding domain superfamily
IPR025884	Methyl-CpG binding protein 2/3, C-terminal domain
IPR032343	Methyl-CpG-binding domain protein 2/3, p55-binding region

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0006346	methylation-dependent chromatin silencing	IDA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007420	brain development	IEA
biological_process	GO:0007507	heart development	IEA
biological_process	GO:0007568	aging	IEA
biological_process	GO:0009888	tissue development	IMP
biological_process	GO:0014070	response to organic cyclic compound	IEA
biological_process	GO:0016573	histone acetylation	IMP
biological_process	GO:0031667	response to nutrient levels	IEA
biological_process	GO:0032355	response to estradiol	IEA
biological_process	GO:0044030	regulation of DNA methylation	IEA
biological_process	GO:0048568	embryonic organ development	IEA
cellular_component	GO:0000785	chromatin	IDA
cellular_component	GO:0000792	heterochromatin	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005694	chromosome	IEA
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0016581	NuRD complex	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008327	methyl-CpG binding	IEA

Pathways (from Reactome)

Pathway description

HDACs deacetylate histones

Regulation of TP53 Activity through Acetylation

RNA Polymerase I Transcription Initiation

Regulation of PTEN gene transcription

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0003721	increased tumor growth/size	"greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cited2^tm1Ycy/Cited2^tm1Ycy Genetic Background: B6.Cg-Cited2^tm1Ycy
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cited2^tm1Ycy/Cited2^tm1Ycy Genetic Background: B6.Cg-Cited2^tm1Ycy
MP:0008537	increased susceptibility to induced colitis	"increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cited2^tm1Ycy/Cited2^tm1Ycy Genetic Background: B6.Cg-Cited2^tm1Ycy
MP:0010157	abnormal small intestinal crypt cell proliferation	"anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cited2^tm1Ycy/Cited2^tm1Ycy Genetic Background: B6.Cg-Cited2^tm1Ycy
MP:0011096	complete embryonic lethality before somite formation	"death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Apc^Min/Apc⁺,Mbd2^tm1Bh/Mbd2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Apc^Min/Apc⁺,Mbd2^tm1Bh/Mbd2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr