Manteia - Molecule gene

ENSMUSG00000034748

Mus musculus

Features

Gene ID:	ENSMUSG00000034748

Biological name :	Sirt6

Synonyms :	P59941 / Sirt6 / sirtuin 6

Possible biological names infered from orthology :	Q8N6T7

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	C1
Gene start:	81621785
Gene end:	81627797

Corresponding Affymetrix probe sets:	10371256 (MoGene1.0st) 1429631_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000048971 Ensembl peptide - ENSMUSP00000113953 Ensembl peptide - ENSMUSP00000118238 NCBI entrez gene - 50721 See in Manteia. MGI - MGI:1354161 RefSeq - XM_011243507 RefSeq - NM_001163430 RefSeq - NM_181586 RefSeq - XM_006513861 RefSeq - XM_006513863 RefSeq Peptide - NP_001156902 RefSeq Peptide - NP_853617 swissprot - P59941 swissprot - Q3UKP1 swissprot - D3YY89 Ensembl - ENSMUSG00000034748

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
sirt6	ENSDARG00000102963	Danio rerio
SIRT6	ENSGALG00000001245	Gallus gallus
SIRT6	ENSG00000077463	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Sirt7 / Q8BKJ9 / NAD-dependent protein deacetylase sirtuin-7 / Q9NRC8* / sirtuin 7*	ENSMUSG00000025138	36

Protein motifs (from Interpro)

Interpro ID	Name
IPR003000	Sirtuin family
IPR026590	Sirtuin family, catalytic core domain
IPR029035	DHS-like NAD/FAD-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0003247	post-embryonic cardiac muscle cell growth involved in heart morphogenesis	IEA
biological_process	GO:0006284	base-excision repair	IMP
biological_process	GO:0006471	protein ADP-ribosylation	IDA
biological_process	GO:0006476	protein deacetylation	IEA
biological_process	GO:0008285	negative regulation of cell proliferation	IMP
biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	IEA
biological_process	GO:0016575	histone deacetylation	IEA
biological_process	GO:0031648	protein destabilization	IMP
biological_process	GO:0031667	response to nutrient levels	IEA
biological_process	GO:0031940	positive regulation of chromatin silencing at telomere	IEA
biological_process	GO:0032206	positive regulation of telomere maintenance	IEA
biological_process	GO:0042593	glucose homeostasis	IMP
biological_process	GO:0045820	negative regulation of glycolytic process	IMP
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IMP
biological_process	GO:0046325	negative regulation of glucose import	IMP
biological_process	GO:0048146	positive regulation of fibroblast proliferation	IMP
biological_process	GO:0061647	histone H3-K9 modification	IEA
biological_process	GO:1902732	positive regulation of chondrocyte proliferation	IEA
biological_process	GO:1905549	positive regulation of telomeric heterochromatin assembly	IEA
biological_process	GO:1905555	positive regulation blood vessel branching	IEA
biological_process	GO:1905564	positive regulation of vascular endothelial cell proliferation	IEA
biological_process	GO:1990619	histone H3-K9 deacetylation	IEA
biological_process	GO:2000648	positive regulation of stem cell proliferation	IMP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005724	nuclear telomeric heterochromatin	IEA
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003714	transcription corepressor activity	IGI
molecular_function	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	IDA
molecular_function	GO:0008270	zinc ion binding	ISS
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0017136	NAD-dependent histone deacetylase activity	ISS
molecular_function	GO:0033558	protein deacetylase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	IMP
molecular_function	GO:0070403	NAD+ binding	IEA

Pathways (from Reactome)

Pathway description

Processing of DNA double-strand break ends

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0000120	malocclusion	"perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0000162	lordosis	"anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Ccl11^tm1Mer/Ccl11^tm1Mer,Ccl24^tm1Mer/Ccl24^tm1Mer Genetic Background: involves: 129S6/SvEvTac
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N * NIH Black Swiss
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0001382	abnormal nursing	"females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N * NIH Black Swiss
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ccl11^tm1Mer/Ccl11^tm1Mer,Ccl24^tm1Mer/Ccl24^tm1Mer Genetic Background: involves: 129S6/SvEvTac
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0002816	colitis	"local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Ccl11^tm1Mer/Ccl11^tm1Mer,Ccl24^tm1Mer/Ccl24^tm1Mer Genetic Background: involves: 129S6/SvEvTac
MP:0003786	premature aging	"earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0004029	spontaneous chromosome breakage	"chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004227	increased cellular sensitivity to ionizing radiation	"increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004701	decreased circulating insulin-like growth factor I level	"reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Otud7b^{tm1(NCOM)Cmhd}/Otud7b^{tm1(NCOM)Cmhd} Genetic Background: C57BL/6N-Otud7b^{tm1(NCOM)Cmhd}/Tcp
MP:0005287	narrow eye opening	"less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Ccl11^tm1Mer/Ccl11^tm1Mer,Ccl24^tm1Mer/Ccl24^tm1Mer Genetic Background: involves: 129S6/SvEvTac
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N * NIH Black Swiss
MP:0005641	increased mean corpuscular hemoglobin concentration	"greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]	Show Allelic Composition: Otud7b^{tm1(NCOM)Cmhd}/Otud7b^{tm1(NCOM)Cmhd} Genetic Background: C57BL/6N-Otud7b^{tm1(NCOM)Cmhd}/Tcp
MP:0008008	early cellular replicative senescence	"increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0008402	increased cellular sensitivity to alkylating agents	"greater incidence of cell death following exposure to agents that cause DNA damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008737	abnormal spleen physiology	"any anomaly in the function of the organ that filters blood and stores red corpuscles and platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0011083	complete lethality at weaning	"premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]	Show Allelic Composition: Esx1^tm1Bhr/Esx1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000041238	Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*	/ reaction
ENSMUSG00000060981	P62806 / Hist1h4h / Histone H4	/ complex / reaction
ENSMUSG00000034748	Sirt6 / P59941 / sirtuin 6 / Q8N6T7*	/ reaction
ENSMUSG00000100210	P84228 / Hist1h3f / Histone H3.2	/ complex / reaction
ENSMUSG00000099517	P68433 / Hist1h3g / Histone H3.1	/ reaction / complex
ENSMUSG00000060743	H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr