ENSG00000077463


Homo sapiens

Features
Gene ID: ENSG00000077463
  
Biological name :SIRT6
  
Synonyms : Q8N6T7 / SIRT6 / sirtuin 6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 4174109
Gene end: 4182604
  
Corresponding Affymetrix probe sets: 219613_s_at (Human Genome U133 Plus 2.0 Array)   233179_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473085
Ensembl peptide - ENSP00000471837
Ensembl peptide - ENSP00000472023
Ensembl peptide - ENSP00000305310
Ensembl peptide - ENSP00000337332
Ensembl peptide - ENSP00000469001
Ensembl peptide - ENSP00000470215
Ensembl peptide - ENSP00000471123
NCBI entrez gene - 51548     See in Manteia.
OMIM - 606211
RefSeq - NM_001321059
RefSeq - NM_001193285
RefSeq - NM_001321058
RefSeq - NM_001321060
RefSeq - NM_001321061
RefSeq - NM_001321062
RefSeq - NM_001321063
RefSeq - NM_001321064
RefSeq - NM_016539
RefSeq Peptide - NP_001307991
RefSeq Peptide - NP_001307992
RefSeq Peptide - NP_001307993
RefSeq Peptide - NP_057623
RefSeq Peptide - NP_001180214
RefSeq Peptide - NP_001307987
RefSeq Peptide - NP_001307988
RefSeq Peptide - NP_001307989
RefSeq Peptide - NP_001307990
swissprot - M0R1F6
swissprot - Q8N6T7
swissprot - M0R1N9
swissprot - M0QXA0
swissprot - M0QZ09
swissprot - M0R0B2
Ensembl - ENSG00000077463
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt6ENSDARG00000102963Danio rerio
 SIRT6ENSGALG00000001245Gallus gallus
 Sirt6ENSMUSG00000034748Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT7 / Q9NRC8 / sirtuin 7ENSG0000018753135


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003247 post-embryonic cardiac muscle cell growth involved in heart morphogenesis IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IDA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0031940 positive regulation of chromatin silencing at telomere IMP
 biological_processGO:0032206 positive regulation of telomere maintenance IMP
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0045820 negative regulation of glycolytic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0046325 negative regulation of glucose import IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0061647 histone H3-K9 modification IEA
 biological_processGO:1902732 positive regulation of chondrocyte proliferation IMP
 biological_processGO:1905549 positive regulation of telomeric heterochromatin assembly IMP
 biological_processGO:1905555 positive regulation blood vessel branching IMP
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IMP
 biological_processGO:1990619 histone H3-K9 deacetylation IEA
 biological_processGO:2000648 positive regulation of stem cell proliferation IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005724 nuclear telomeric heterochromatin IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity TAS
 molecular_functionGO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity ISS
 molecular_functionGO:0033558 protein deacetylase activity IEA
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
Processing of DNA double-strand break ends


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000077463 SIRT6 / Q8N6T7 / sirtuin 6  / reaction
 ENSG00000101773 RBBP8 / Q99708 / RB binding protein 8, endonuclease  / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction






 

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