ENSGALG00000001245


Gallus gallus

Features
Gene ID: ENSGALG00000001245
  
Biological name :SIRT6
  
Synonyms : NAD-dependent protein deacetylase sirtuin-6 / SIRT6
  
Possible biological names infered from orthology : P59941 / Q8N6T7 / sirtuin 6
  
Species: Gallus gallus
  
Chr. number: 28
Strand: 1
Band:
Gene start: 2625855
Gene end: 2632332
  
Corresponding Affymetrix probe sets: Gga.1726.1.S1_s_at (Chicken Array)   GgaAffx.11419.1.S1_at (Chicken Array)   GgaAffx.23594.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000001888
Ensembl peptide - ENSGALP00000062638
Ensembl peptide - ENSGALP00000059675
Ensembl peptide - ENSGALP00000059125
Ensembl peptide - ENSGALP00000052430
NCBI entrez gene - 428332     See in Manteia.
RefSeq - NM_001039320
RefSeq Peptide - NP_001034409
swissprot - A0A1L1RK62
swissprot - A0A1L1RUY8
swissprot - F1P0C4
swissprot - A0A1D5PHZ8
swissprot - A0A1L1RLQ2
Ensembl - ENSGALG00000001245
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt6ENSDARG00000102963Danio rerio
 SIRT6ENSG00000077463Homo sapiens
 Sirt6ENSMUSG00000034748Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT7 / sirtuin 7 / Q8BKJ9* / Q9NRC8* / NAD-dependent protein deacetylase sirtuin-7 *ENSGALG0000000728634


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026590  Sirtuin family, catalytic core domain
 IPR026591  Sirtuin, catalytic core small domain superfamily
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0031940 positive regulation of chromatin silencing at telomere IEA
 biological_processGO:0032206 positive regulation of telomere maintenance IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0045820 negative regulation of glycolytic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0046325 negative regulation of glucose import IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0061647 histone H3-K9 modification IEA
 biological_processGO:1902732 positive regulation of chondrocyte proliferation IEA
 biological_processGO:1905549 positive regulation of telomeric heterochromatin assembly IEA
 biological_processGO:1905555 positive regulation blood vessel branching IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:1990619 histone H3-K9 deacetylation IEA
 biological_processGO:2000648 positive regulation of stem cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005724 nuclear telomeric heterochromatin IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA
 molecular_functionGO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) IEA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Processing of DNA double-strand break ends


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr