ENSMUSG00000025138


Mus musculus

Features
Gene ID: ENSMUSG00000025138
  
Biological name :Sirt7
  
Synonyms : NAD-dependent protein deacetylase sirtuin-7 / Q8BKJ9 / Sirt7
  
Possible biological names infered from orthology : Q9NRC8 / sirtuin 7
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120618372
Gene end: 120625240
  
Corresponding Affymetrix probe sets: 10393866 (MoGene1.0st)   1424238_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079093
Ensembl peptide - ENSMUSP00000120405
Ensembl peptide - ENSMUSP00000101789
NCBI entrez gene - 209011     See in Manteia.
MGI - MGI:2385849
RefSeq - NM_153056
RefSeq - XM_017314408
RefSeq Peptide - NP_694696
swissprot - A2ABY8
swissprot - Q8BKJ9
swissprot - A2ABY6
Ensembl - ENSMUSG00000025138
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt7ENSDARG00000060645Danio rerio
 SIRT7ENSGALG00000007286Gallus gallus
 SIRT7ENSG00000187531Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sirt6 / P59941 / sirtuin 6 / Q8N6T7*ENSMUSG0000003474830


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007072 positive regulation of transcription involved in exit from mitosis IEA
 biological_processGO:0009303 rRNA transcription IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0070933 histone H4 deacetylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005731 nucleolus organizer region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070403 NAD+ binding IEA
 molecular_functionGO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific) IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0008842 lipofuscinosis "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr