ENSG00000163041


Homo sapiens

Features
Gene ID: ENSG00000163041
  
Biological name :H3F3A
  
Synonyms : H3F3A / H3 histone family member 3A / P84243
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q42.12
Gene start: 226061851
Gene end: 226072001
  
Corresponding Affymetrix probe sets: 200080_s_at (Human Genome U133 Plus 2.0 Array)   208755_x_at (Human Genome U133 Plus 2.0 Array)   211940_x_at (Human Genome U133 Plus 2.0 Array)   213826_s_at (Human Genome U133 Plus 2.0 Array)   213828_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355778
Ensembl peptide - ENSP00000355781
Ensembl peptide - ENSP00000355780
Ensembl peptide - ENSP00000355779
NCBI entrez gene - 3020     See in Manteia.
OMIM - 601128
RefSeq - NM_002107
RefSeq Peptide - NP_002098
swissprot - B4DEB1
swissprot - B2R4P9
swissprot - P84243
Ensembl - ENSG00000163041
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6PI20ENSDARG00000068434Danio rerio
 H3F3CENSGALG00000020078Gallus gallus
 H3f3aENSMUSG00000060743Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H3F3B / P84243 / H3 histone family member 3BENSG00000132475100
Q71DI3 / HIST2H3A / histone cluster 2 H3 family member aENSG0000020385297
Q71DI3 / HIST2H3D / histone cluster 2 H3 family member dENSG0000018359897
Q71DI3 / HIST2H3C / histone cluster 2 H3 family member cENSG0000020381197
P68431 / HIST1H3I / histone cluster 1 H3 family member iENSG0000027537996
P68431 / HIST1H3H / histone cluster 1 H3 family member hENSG0000027882896
P68431 / HIST1H3D / histone cluster 1 H3 family member dENSG0000019740996
H3F3C / Q6NXT2 / H3 histone family member 3CENSG0000018837596
P68431 / HIST1H3E / histone cluster 1 H3 family member eENSG0000027475096
P68431 / HIST1H3B / histone cluster 1 H3 family member bENSG0000027426796
P68431 / HIST1H3A / histone cluster 1 H3 family member aENSG0000027571496
P68431 / HIST1H3C / histone cluster 1 H3 family member cENSG0000027827296
P68431 / HIST1H3G / histone cluster 1 H3 family member gENSG0000027398396
P68431 / HIST1H3J / histone cluster 1 H3 family member jENSG0000019715396
P68431 / HIST1H3F / histone cluster 1 H3 family member fENSG0000027777596
HIST2H3PS2 / histone cluster 2 H3 pseudogene 2ENSG0000020381894
Q16695 / HIST3H3 / histone cluster 3 H3ENSG0000016814893
H3.Y / histone cluster 2, H3c pseudogeneENSG0000026946681
P04908 / HIST1H2AB / histone cluster 1 H2A family member bENSG0000027846320
P04908 / HIST1H2AE / histone cluster 1 H2A family member eENSG0000027707520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000164  Histone H3/CENP-A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0006334 nucleosome assembly IMP
 biological_processGO:0006336 DNA replication-independent nucleosome assembly IDA
 biological_processGO:0006997 nucleus organization IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0031508 pericentric heterochromatin assembly IEA
 biological_processGO:0031509 telomeric heterochromatin assembly IEA
 biological_processGO:0032200 telomere organization TAS
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0042692 muscle cell differentiation IEA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045814 negative regulation of gene expression, epigenetic TAS
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 biological_processGO:0048477 oogenesis IEA
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:0090230 regulation of centromere complex assembly IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 biological_processGO:1902340 negative regulation of chromosome condensation IEA
 cellular_componentGO:0000228 nuclear chromosome IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0000786 nucleosome IDA
 cellular_componentGO:0000788 nuclear nucleosome IDA
 cellular_componentGO:0001740 Barr body IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031492 nucleosomal DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Amyloid fiber formation
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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