ENSG00000203852


Homo sapiens

Features
Gene ID: ENSG00000203852
  
Biological name :HIST2H3A
  
Synonyms : HIST2H3A / histone cluster 2 H3 family member a / Q71DI3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q21.2
Gene start: 149852619
Gene end: 149854274
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000385479
NCBI entrez gene - 333932     See in Manteia.
RefSeq - NM_001005464
RefSeq Peptide - NP_001005464
swissprot - Q71DI3
Ensembl - ENSG00000203852
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P84229ENSGALG00000038969Gallus gallus
 P84228ENSMUSG00000074403Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q71DI3 / HIST2H3D / histone cluster 2 H3 family member dENSG00000183598100
Q71DI3 / HIST2H3C / histone cluster 2 H3 family member cENSG00000203811100
P68431 / HIST1H3F / histone cluster 1 H3 family member fENSG0000027777599
P68431 / HIST1H3J / histone cluster 1 H3 family member jENSG0000019715399
P68431 / HIST1H3E / histone cluster 1 H3 family member eENSG0000027475099
P68431 / HIST1H3C / histone cluster 1 H3 family member cENSG0000027827299
P68431 / HIST1H3A / histone cluster 1 H3 family member aENSG0000027571499
P68431 / HIST1H3D / histone cluster 1 H3 family member dENSG0000019740999
P68431 / HIST1H3B / histone cluster 1 H3 family member bENSG0000027426799
P68431 / HIST1H3H / histone cluster 1 H3 family member hENSG0000027882899
P68431 / HIST1H3I / histone cluster 1 H3 family member iENSG0000027537999
P68431 / HIST1H3G / histone cluster 1 H3 family member gENSG0000027398399
H3F3B / P84243 / H3 histone family member 3BENSG0000013247597
H3F3A / P84243 / H3 histone family member 3AENSG0000016304197
HIST2H3PS2 / histone cluster 2 H3 pseudogene 2ENSG0000020381897
Q16695 / HIST3H3 / histone cluster 3 H3ENSG0000016814896
H3F3C / Q6NXT2 / H3 histone family member 3CENSG0000018837594
H3.Y / histone cluster 2, H3c pseudogeneENSG0000026946679
P04908 / HIST1H2AE / histone cluster 1 H2A family member eENSG0000027707520
P04908 / HIST1H2AB / histone cluster 1 H2A family member bENSG0000027846320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000164  Histone H3/CENP-A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006325 chromatin organization TAS
 biological_processGO:0006334 nucleosome assembly IDA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0038111 interleukin-7-mediated signaling pathway TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045814 negative regulation of gene expression, epigenetic TAS
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 cellular_componentGO:0000786 nucleosome IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031492 nucleosomal DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
RMTs methylate histone arginines
Chromatin modifying enzymes
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Amyloid fiber formation
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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