ENSG00000277075


Homo sapiens

Features
Gene ID: ENSG00000277075
  
Biological name :HIST1H2AE
  
Synonyms : HIST1H2AE / histone cluster 1 H2A family member e / P04908
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.2
Gene start: 26216975
Gene end: 26217483
  
Corresponding Affymetrix probe sets: 214469_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000303373
NCBI entrez gene - 3012     See in Manteia.
OMIM - 602786
RefSeq - NM_021052
RefSeq Peptide - NP_066390
swissprot - P04908
swissprot - Q08AJ9
Ensembl - ENSG00000277075
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q4QRF4ENSDARG00000105484Danio rerio
 C0HKE1ENSMUSG00000094777Mus musculus
 C0HKE1ENSMUSG00000094248Mus musculus
 Q8CGP6ENSMUSG00000069302Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P04908 / HIST1H2AB / histone cluster 1 H2A family member bENSG00000278463100
HIST2H3PS2 / histone cluster 2 H3 pseudogene 2ENSG0000020381821
P68431 / HIST1H3F / histone cluster 1 H3 family member fENSG0000027777521
H3F3C / Q6NXT2 / H3 histone family member 3CENSG0000018837521
P68431 / HIST1H3E / histone cluster 1 H3 family member eENSG0000027475021
H3F3B / P84243 / H3 histone family member 3BENSG0000013247521
P68431 / HIST1H3H / histone cluster 1 H3 family member hENSG0000027882821
P68431 / HIST1H3B / histone cluster 1 H3 family member bENSG0000027426721
Q71DI3 / HIST2H3A / histone cluster 2 H3 family member aENSG0000020385221
P68431 / HIST1H3I / histone cluster 1 H3 family member iENSG0000027537921
Q71DI3 / HIST2H3D / histone cluster 2 H3 family member dENSG0000018359821
P68431 / HIST1H3G / histone cluster 1 H3 family member gENSG0000027398321
P68431 / HIST1H3C / histone cluster 1 H3 family member cENSG0000027827221
P68431 / HIST1H3A / histone cluster 1 H3 family member aENSG0000027571421
Q71DI3 / HIST2H3C / histone cluster 2 H3 family member cENSG0000020381121
H3F3A / P84243 / H3 histone family member 3AENSG0000016304121
P68431 / HIST1H3D / histone cluster 1 H3 family member dENSG0000019740921
P68431 / HIST1H3J / histone cluster 1 H3 family member jENSG0000019715321
Q16695 / HIST3H3 / histone cluster 3 H3ENSG0000016814820
H3.Y / histone cluster 2, H3c pseudogeneENSG0000026946616


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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