ENSMUSG00000037876


Mus musculus

Features
Gene ID: ENSMUSG00000037876
  
Biological name :Jmjd1c
  
Synonyms : Jmjd1c / Probable JmjC domain-containing histone demethylation protein 2C / Q69ZK6
  
Possible biological names infered from orthology : jumonji domain containing 1C / Q15652
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B5.1
Gene start: 67096125
Gene end: 67256326
  
Corresponding Affymetrix probe sets: 10363703 (MoGene1.0st)   10363706 (MoGene1.0st)   1426900_at (Mouse Genome 430 2.0 Array)   1439998_at (Mouse Genome 430 2.0 Array)   1448049_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056227
Ensembl peptide - ENSMUSP00000133700
Ensembl peptide - ENSMUSP00000134246
Ensembl peptide - ENSMUSP00000134551
NCBI entrez gene - 108829     See in Manteia.
MGI - MGI:1918614
RefSeq - XM_006513044
RefSeq - XM_006513037
RefSeq - XM_006513038
RefSeq - XM_006513039
RefSeq - XM_006513040
RefSeq - XM_006513041
RefSeq - XM_006513042
RefSeq - NM_001242396
RefSeq - NM_207221
RefSeq - XM_006513035
RefSeq - XM_006513036
RefSeq Peptide - NP_001229325
RefSeq Peptide - NP_997104
swissprot - G3UZM1
swissprot - G3UYW3
swissprot - Q69ZK6
swissprot - A0A0A0MQ98
Ensembl - ENSMUSG00000037876
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jmjd1cbENSDARG00000079939Danio rerio
 JMJD1CENSGALG00000002942Gallus gallus
 JMJD1CENSG00000171988Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdm3b / lysine demethylase 3B / Q7LBC6*ENSMUSG0000003877325
Kdm3a / Q6PCM1 / Lysine-specific demethylase 3A / Q9Y4C1* / lysine demethylase 3A*ENSMUSG0000005347020
Hr / Q61645 / Lysine-specific demethylase hairless / O43593* / HR, lysine demethylase and nuclear receptor corepressor*ENSMUSG0000002209612


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003382 epithelial cell morphogenesis IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0033169 histone H3-K9 demethylation IBA
 biological_processGO:0036098 male germ-line stem cell population maintenance IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0072520 seminiferous tubule development IMP
 biological_processGO:0098727 maintenance of cell number IMP
 biological_processGO:1990636 reproductive senescence IMP
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IBA
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Xcr1tm1Ksho/Xcr1+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Xcr1tm1Ksho/Xcr1+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Xcr1tm1Ksho/Xcr1+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xcr1tm1Ksho/Xcr1+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Xcr1tm1Ksho/Xcr1+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xcr1tm1Ksho/Xcr1+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xcr1tm1Ksho/Xcr1+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Xcr1tm1Ksho/Xcr1+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Xcr1tm1Ksho/Xcr1+
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction






 

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