ENSMUSG00000053470


Mus musculus

Features
Gene ID: ENSMUSG00000053470
  
Biological name :Kdm3a
  
Synonyms : Kdm3a / Lysine-specific demethylase 3A / Q6PCM1
  
Possible biological names infered from orthology : lysine demethylase 3A / Q9Y4C1
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C1
Gene start: 71588972
Gene end: 71632990
  
Corresponding Affymetrix probe sets: 10545308 (MoGene1.0st)   1426810_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145959
Ensembl peptide - ENSMUSP00000145992
Ensembl peptide - ENSMUSP00000065716
Ensembl peptide - ENSMUSP00000128789
Ensembl peptide - ENSMUSP00000145719
NCBI entrez gene - 104263     See in Manteia.
MGI - MGI:98847
RefSeq - XM_006505264
RefSeq - XM_006505265
RefSeq - NM_001038695
RefSeq - NM_173001
RefSeq Peptide - NP_001033784
RefSeq Peptide - NP_766589
swissprot - Q6PCM1
swissprot - A0A0U1RPI3
swissprot - A0A0U1RNV6
Ensembl - ENSMUSG00000053470
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KDM3AENSGALG00000015803Gallus gallus
 KDM3AENSG00000115548Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdm3b / lysine demethylase 3B / Q7LBC6*ENSMUSG0000003877349
Jmjd1c / Q69ZK6 / Probable JmjC domain-containing histone demethylation protein 2C / Q15652* / jumonji domain containing 1C*ENSMUSG0000003787637
Hr / Q61645 / Lysine-specific demethylase hairless / O43593* / HR, lysine demethylase and nuclear receptor corepressor*ENSMUSG0000002209617


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007290 spermatid nucleus elongation IMP
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030521 androgen receptor signaling pathway IEA
 biological_processGO:0033169 histone H3-K9 demethylation IEA
 biological_processGO:0036123 histone H3-K9 dimethylation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046293 formaldehyde biosynthetic process IEA
 biological_processGO:0051573 negative regulation of histone H3-K9 methylation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000036 regulation of stem cell population maintenance IGI
 biological_processGO:2000736 regulation of stem cell differentiation IMP
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IBA
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Daglatm1Pado/Daglatm1Pado
Genetic Background: C57BL/6-Daglatm1Pado

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kdm3atm1Jxu/Kdm3atm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

Allelic Composition: Kdm3atm1Jxu/Kdm3atm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kdm3atm1Jxu/Kdm3atm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kdm3atm1Jxu/Kdm3atm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kdm3atm1Jxu/Kdm3atm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdm3atm1Jxu/Kdm3atm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
Show

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kdm3atm1Jxu/Kdm3atm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdm3atm1Jxu/Kdm3atm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009121 increased white fat cell lipid droplet size "increase in the size of the single large lipid droplet or vacuole of white fat cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0009304 increased retroperitoneal fat pad weight 
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Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

Allelic Composition: Kdm3atm1.1Jsak/Kdm3atm1.1Jsak
Genetic Background: involves: C57BL/6 * CBA

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
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Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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