ENSG00000115548


Homo sapiens

Features
Gene ID: ENSG00000115548
  
Biological name :KDM3A
  
Synonyms : KDM3A / lysine demethylase 3A / Q9Y4C1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p11.2
Gene start: 86440647
Gene end: 86492716
  
Corresponding Affymetrix probe sets: 212689_s_at (Human Genome U133 Plus 2.0 Array)   242758_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394691
Ensembl peptide - ENSP00000438324
Ensembl peptide - ENSP00000397660
Ensembl peptide - ENSP00000396561
Ensembl peptide - ENSP00000323659
Ensembl peptide - ENSP00000386516
Ensembl peptide - ENSP00000386660
NCBI entrez gene - 55818     See in Manteia.
OMIM - 611512
RefSeq - XM_017004494
RefSeq - NM_001146688
RefSeq - NM_018433
RefSeq - XM_006712051
RefSeq - XM_017004493
RefSeq Peptide - NP_001140160
RefSeq Peptide - NP_060903
swissprot - F5H070
swissprot - F8WE62
swissprot - Q9Y4C1
swissprot - C9J7Q7
swissprot - C9JC73
Ensembl - ENSG00000115548
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KDM3AENSGALG00000015803Gallus gallus
 Kdm3aENSMUSG00000053470Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM3B / Q7LBC6 / lysine demethylase 3BENSG0000012073350
JMJD1C / Q15652 / jumonji domain containing 1CENSG0000017198839
HR / O43593 / HR, lysine demethylase and nuclear receptor corepressorENSG0000016845317


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007290 spermatid nucleus elongation IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IDA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030521 androgen receptor signaling pathway IDA
 biological_processGO:0033169 histone H3-K9 demethylation IMP
 biological_processGO:0036123 histone H3-K9 dimethylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046293 formaldehyde biosynthetic process IDA
 biological_processGO:0051573 negative regulation of histone H3-K9 methylation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000036 regulation of stem cell population maintenance IEA
 biological_processGO:2000736 regulation of stem cell differentiation IEA
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005506 iron ion binding IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IBA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding IDA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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