ENSMUSG00000051977


Mus musculus

Features
Gene ID: ENSMUSG00000051977
  
Biological name :Prdm9
  
Synonyms : Prdm9 / PR domain containing 9 / Q96EQ9
  
Possible biological names infered from orthology : PR/SET domain 9 / Q9NQV7
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A2
Gene start: 15543079
Gene end: 15564354
  
Corresponding Affymetrix probe sets: 10448064 (MoGene1.0st)   1426107_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118454
Ensembl peptide - ENSMUSP00000131871
NCBI entrez gene - 213389     See in Manteia.
MGI - MGI:2384854
RefSeq - XM_017317380
RefSeq - NM_144809
RefSeq - XM_006523989
RefSeq - XM_006523990
RefSeq - XM_011246355
RefSeq - XM_006523988
RefSeq Peptide - NP_659058
swissprot - Q96EQ9
swissprot - E9Q4V2
Ensembl - ENSMUSG00000051977
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRDM9ENSG00000164256Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zfp169 / zinc finger protein 169ENSMUSG0000005095427


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR001909  Krueppel-associated box
 IPR003655  Krueppel-associated box-related
 IPR013087  Zinc finger C2H2-type
 IPR019041  SSXRD motif
 IPR036051  KRAB domain superfamily
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006311 meiotic gene conversion IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0010845 positive regulation of reciprocal meiotic recombination IEA
 biological_processGO:0016571 histone methylation IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051568 histone H3-K4 methylation IEA
 biological_processGO:0060903 positive regulation of meiosis I IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0010844 recombination hotspot binding IMP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) EXP
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
Meiotic recombination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Apctm1.1Alew/Apctm1.1Alew
Genetic Background: B6.129-Apctm1.1Alew

Allelic Composition: Prdm9M1045Lja/Prdm9+
Genetic Background: involves: C57BL/6J * DBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Prdm9repro7/Prdm9repro7
Genetic Background: B6;C3Fe-Prdm9repro7/J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Prdm9repro7/Prdm9repro7
Genetic Background: B6;C3Fe-Prdm9repro7/J

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg,Tg(CAG-XBP1*/Venus)#Miur/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm9M1045Lja/Prdm9+
Genetic Background: involves: C57BL/6J * DBA

 MP:0002208 abnormal germ cell morphology "anomalous structure of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apctm1.1Alew/Apctm1.1Alew
Genetic Background: B6.129-Apctm1.1Alew

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm9repro7/Prdm9repro7
Genetic Background: B6;C3Fe-Prdm9repro7/J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Prdm9repro7/Prdm9repro7
Genetic Background: B6;C3Fe-Prdm9repro7/J

Allelic Composition: Prdm9M1045Lja/Prdm9M1045Lja
Genetic Background: involves: C57BL/6J * DBA

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm9M1045Lja/Prdm9+
Genetic Background: involves: C57BL/6J * DBA

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Prdm9repro7/Prdm9repro7
Genetic Background: B6;C3Fe-Prdm9repro7/J

Allelic Composition: Prdm9M1045Lja/Prdm9M1045Lja
Genetic Background: involves: C57BL/6J * DBA

Allelic Composition: Prdm9M1045Lja/Prdm9+
Genetic Background: involves: C57BL/6J * DBA

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm9M1045Lja/Prdm9+
Genetic Background: involves: C57BL/6J * DBA

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Prdm9repro7/Prdm9repro7
Genetic Background: B6;C3Fe-Prdm9repro7/J

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr