ENSMUSG00000028397


Mus musculus

Features
Gene ID: ENSMUSG00000028397
  
Biological name :Kdm4c
  
Synonyms : Kdm4c / Mus musculus lysine (K)-specific demethylase 4C (Kdm4c), transcript variant 3, mRNA. / Q8VCD7
  
Possible biological names infered from orthology : lysine demethylase 4C / Q9H3R0
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C3
Gene start: 74242497
Gene end: 74405860
  
Corresponding Affymetrix probe sets: 10505587 (MoGene1.0st)   1424458_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030102
Ensembl peptide - ENSMUSP00000077017
Ensembl peptide - ENSMUSP00000118728
NCBI entrez gene - 76804     See in Manteia.
MGI - MGI:1924054
RefSeq - XM_006538354
RefSeq - NM_001172095
RefSeq - NM_001356561
RefSeq - NM_144787
RefSeq - XM_006538350
RefSeq - XM_006538351
RefSeq - XM_006538352
RefSeq Peptide - NP_659036
RefSeq Peptide - NP_001165566
RefSeq Peptide - NP_001343490
swissprot - I7HLQ5
swissprot - Q8VCD7
swissprot - A2BEG5
Ensembl - ENSMUSG00000028397
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm4cENSDARG00000061504Danio rerio
 KDM4CENSGALG00000020557Gallus gallus
 KDM4CENSG00000107077Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*ENSMUSG0000002420152
Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*ENSMUSG0000003332651
Kdm4d / Q3U2K5 / Lysine-specific demethylase 4D / KDM4E* / KDM4F* / B2RXH2* / Q6B0I6* / lysine demethylase 4E* / lysine demethylase 4D* / lysine demethylase 4F*ENSMUSG0000005391425


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002999  Tudor domain
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR034732  Extended PHD (ePHD) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001825 blastocyst formation IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0033169 histone H3-K9 demethylation ISS
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation ISO
 biological_processGO:1900113 negative regulation of histone H3-K9 trimethylation IDA
 biological_processGO:2000036 regulation of stem cell population maintenance IGI
 biological_processGO:2000736 regulation of stem cell differentiation IDA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005721 pericentric heterochromatin IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0032452 histone demethylase activity ISO
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding IPI
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) ISO


Pathways (from Reactome)
Pathway description
HDMs demethylate histones
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

Allelic Composition: Kdm4cGt(897)Tgen/Kdm4c+
Genetic Background: B6.Cg-Kdm4cGt(897)Tgen

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdm4cGt(897)Tgen/Kdm4c+
Genetic Background: B6.Cg-Kdm4cGt(897)Tgen

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sec24ctm1d(EUCOMM)Wtsi/Sec24c+,Sec24dGt(RRT226)Byg/Sec24d+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N * FVB/N

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
Show

Allelic Composition: Prmt8tm1d(EUCOMM)Wtsi/Prmt8+
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057672 Pkn1 / P70268 / Serine/threonine-protein kinase N1 / Q16512* / protein kinase N1*  / reaction / complex
 ENSMUSG00000046532 Ar / P19091 / Androgen receptor / P10275*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr