ENSMUSG00000053914


Mus musculus

Features
Gene ID: ENSMUSG00000053914
  
Biological name :Kdm4d
  
Synonyms : Kdm4d / Lysine-specific demethylase 4D / Q3U2K5
  
Possible biological names infered from orthology : B2RXH2 / KDM4E / KDM4F / lysine demethylase 4D / lysine demethylase 4E / lysine demethylase 4F / Q6B0I6
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A2
Gene start: 14462548
Gene end: 14500482
  
Corresponding Affymetrix probe sets: 10590915 (MoGene1.0st)   1440105_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061632
Ensembl peptide - ENSMUSP00000111311
NCBI entrez gene - 244694     See in Manteia.
MGI - MGI:3606484
RefSeq - NM_173433
RefSeq - XM_006510270
RefSeq - XM_006510271
RefSeq Peptide - NP_775609
swissprot - Q3U2K5
swissprot - Z4YLE9
Ensembl - ENSMUSG00000053914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KDM4DENSG00000186280Homo sapiens
 KDM4EENSG00000235268Homo sapiens
 KDM4FENSG00000255855Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*ENSMUSG0000002420153
Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*ENSMUSG0000003332651
Kdm4c / Q8VCD7 / Mus musculus lysine (K)-specific demethylase 4C (Kdm4c), transcript variant 3, mRNA. / Q9H3R0* / lysine demethylase 4C*ENSMUSG0000002839751


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain
 IPR003349  JmjN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination ISO
 biological_processGO:0001932 regulation of protein phosphorylation ISO
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0033169 histone H3-K9 demethylation ISO
 biological_processGO:0035563 positive regulation of chromatin binding ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071479 cellular response to ionizing radiation ISO
 biological_processGO:1900113 negative regulation of histone H3-K9 trimethylation IDA
 biological_processGO:2001034 positive regulation of double-strand break repair via nonhomologous end joining ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005721 pericentric heterochromatin IDA
 cellular_componentGO:0035861 site of double-strand break ISO
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0032452 histone demethylase activity IDA
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001148 enlarged testes "increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6-Pln)11Egk/?
Genetic Background: involves: 129S2/SvPas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6-Pln)11Egk/?
Genetic Background: involves: 129S2/SvPas

 MP:0006308 enlarged seminiferous tubules "increased diameter of the tubules in the testes where spermatogenesis occurs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6-Pln)11Egk/?
Genetic Background: involves: 129S2/SvPas

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6-Pln)11Egk/?
Genetic Background: involves: 129S2/SvPas

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6-Pln)11Egk/?
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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