ENSG00000131408


Homo sapiens

Features
Gene ID: ENSG00000131408
  
Biological name :NR1H2
  
Synonyms : NR1H2 / nuclear receptor subfamily 1 group H member 2 / P55055
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.33
Gene start: 50329653
Gene end: 50382982
  
Corresponding Affymetrix probe sets: 218215_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000469778
Ensembl peptide - ENSP00000471194
Ensembl peptide - ENSP00000471294
Ensembl peptide - ENSP00000472271
Ensembl peptide - ENSP00000472526
Ensembl peptide - ENSP00000473099
Ensembl peptide - ENSP00000253727
Ensembl peptide - ENSP00000396151
Ensembl peptide - ENSP00000470518
Ensembl peptide - ENSP00000472138
NCBI entrez gene - 7376     See in Manteia.
OMIM - 600380
RefSeq - NM_001256647
RefSeq - NM_007121
RefSeq Peptide - NP_001243576
RefSeq Peptide - NP_009052
swissprot - P55055
swissprot - M0QYE6
swissprot - M0QZF5
swissprot - M0R0K3
swissprot - M0R1V8
swissprot - M0R229
swissprot - M0R2F9
swissprot - M0R3A7
Ensembl - ENSG00000131408
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Nr1h2ENSMUSG00000060601Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3ENSG0000002543460
NR1H4 / Q96RI1 / nuclear receptor subfamily 1 group H member 4ENSG0000001250433
RARG / P13631 / retinoic acid receptor gammaENSG0000017281928
RARA / P10276 / retinoic acid receptor alphaENSG0000013175927
RARB / P10826 / retinoic acid receptor betaENSG0000007709227
VDR / P11473 / vitamin D receptorENSG0000011142426
NR1I2 / O75469 / nuclear receptor subfamily 1 group I member 2ENSG0000014485225
THRB / P10828 / thyroid hormone receptor betaENSG0000015109025
NR1I3 / Q14994 / nuclear receptor subfamily 1 group I member 3ENSG0000014325724
THRA / P10827 / thyroid hormone receptor, alphaENSG0000012635124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR023257  Liver X receptor
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IC
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IMP
 biological_processGO:0010875 positive regulation of cholesterol efflux IMP
 biological_processGO:0010884 positive regulation of lipid storage IEA
 biological_processGO:0010887 negative regulation of cholesterol storage IMP
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IMP
 biological_processGO:0032369 negative regulation of lipid transport IMP
 biological_processGO:0032376 positive regulation of cholesterol transport IDA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0044255 cellular lipid metabolic process IEA
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process IMP
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048384 retinoic acid receptor signaling pathway IEA
 biological_processGO:0048550 negative regulation of pinocytosis IMP
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity IMP
 biological_processGO:0055088 lipid homeostasis IEA
 biological_processGO:0060336 negative regulation of interferon-gamma-mediated signaling pathway NAS
 biological_processGO:0090108 positive regulation of high-density lipoprotein particle assembly IEA
 biological_processGO:0090187 positive regulation of pancreatic juice secretion IEA
 biological_processGO:0090340 positive regulation of secretion of lysosomal enzymes IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0034191 apolipoprotein A-I receptor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding IEA
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
VLDLR internalisation and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101849 TBL1X / O60907 / transducin beta like 1 X-linked  / complex
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / complex
 ENSG00000141027 NCOR1 / O75376 / nuclear receptor corepressor 1  / complex
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000177565 Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1  / complex
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / complex
 ENSG00000196498 NCOR2 / Q9Y618 / nuclear receptor corepressor 2  / complex
 ENSG00000132522 GPS2 / Q13227 / G protein pathway suppressor 2  / complex






 

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