ENSG00000132522


Homo sapiens

Features
Gene ID: ENSG00000132522
  
Biological name :GPS2
  
Synonyms : G protein pathway suppressor 2 / GPS2 / Q13227
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.1
Gene start: 7311324
Gene end: 7315564
  
Corresponding Affymetrix probe sets: 209350_s_at (Human Genome U133 Plus 2.0 Array)   213757_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000460836
Ensembl peptide - ENSP00000461624
Ensembl peptide - ENSP00000370104
Ensembl peptide - ENSP00000379841
Ensembl peptide - ENSP00000458837
Ensembl peptide - ENSP00000459357
NCBI entrez gene - 2874     See in Manteia.
OMIM - 601935
RefSeq - NM_004489
RefSeq Peptide - NP_004480
swissprot - I3L3Y9
swissprot - I3L4X7
swissprot - Q13227
swissprot - I3L1H4
swissprot - I3L242
Ensembl - ENSG00000132522
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gps2ENSDARG00000035558Danio rerio
 Gps2ENSMUSG00000023170Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026094  G protein pathway suppressor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000188 inactivation of MAPK activity TAS
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0046329 negative regulation of JNK cascade IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005095 GTPase inhibitor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030332 cyclin binding IPI


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
HDACs deacetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169057 MECP2 / P51608 / methyl-CpG binding protein 2  / reaction / complex
 ENSG00000204231 RXRB / P28702 / retinoid X receptor beta  / complex
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / complex
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / complex
 ENSG00000177565 Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1  / complex
 ENSG00000132522 GPS2 / Q13227 / G protein pathway suppressor 2  / complex
 ENSG00000025434 NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3  / complex
 ENSG00000101849 TBL1X / O60907 / transducin beta like 1 X-linked  / complex
 ENSG00000141027 NCOR1 / O75376 / nuclear receptor corepressor 1  / complex
 ENSG00000131408 NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2  / complex
 ENSG00000196498 NCOR2 / Q9Y618 / nuclear receptor corepressor 2  / complex






 

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