ENSG00000144852


Homo sapiens

Features
Gene ID: ENSG00000144852
  
Biological name :NR1I2
  
Synonyms : NR1I2 / nuclear receptor subfamily 1 group I member 2 / O75469
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q13.33
Gene start: 119780484
Gene end: 119818485
  
Corresponding Affymetrix probe sets: 207202_s_at (Human Genome U133 Plus 2.0 Array)   207203_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000492881
Ensembl peptide - ENSP00000377319
Ensembl peptide - ENSP00000336528
Ensembl peptide - ENSP00000420297
Ensembl peptide - ENSP00000492264
NCBI entrez gene - 8856     See in Manteia.
OMIM - 603065
RefSeq - NM_033013
RefSeq - NM_003889
RefSeq - NM_022002
RefSeq Peptide - NP_003880
RefSeq Peptide - NP_148934
RefSeq Peptide - NP_071285
swissprot - O75469
swissprot - F1D8P9
swissprot - H0Y8E2
swissprot - J3KPQ3
Ensembl - ENSG00000144852
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr1i2ENSDARG00000029766Danio rerio
 Nr1i2ENSMUSG00000022809Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VDR / P11473 / vitamin D receptorENSG0000011142437
NR1I3 / Q14994 / nuclear receptor subfamily 1 group I member 3ENSG0000014325735
THRB / P10828 / thyroid hormone receptor betaENSG0000015109025
RARB / P10826 / retinoic acid receptor betaENSG0000007709225
NR1H4 / Q96RI1 / nuclear receptor subfamily 1 group H member 4ENSG0000001250425
RARA / P10276 / retinoic acid receptor alphaENSG0000013175925
NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2ENSG0000013140825
NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3ENSG0000002543425
RARG / P13631 / retinoic acid receptor gammaENSG0000017281924
THRA / P10827 / thyroid hormone receptor, alphaENSG0000012635123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR001728  Thyroid hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006805 xenobiotic metabolic process IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008202 steroid metabolic process TAS
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0042738 exogenous drug catabolic process IDA
 biological_processGO:0042908 xenobiotic transport IDA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046618 drug export IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0004879 nuclear receptor activity IDA
 molecular_functionGO:0004887 thyroid hormone receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction






 

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