ENSG00000120798


Homo sapiens

Features
Gene ID: ENSG00000120798
  
Biological name :NR2C1
  
Synonyms : NR2C1 / nuclear receptor subfamily 2 group C member 1 / P13056
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q22
Gene start: 95020229
Gene end: 95073703
  
Corresponding Affymetrix probe sets: 204791_at (Human Genome U133 Plus 2.0 Array)   210530_s_at (Human Genome U133 Plus 2.0 Array)   210531_at (Human Genome U133 Plus 2.0 Array)   229956_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450225
Ensembl peptide - ENSP00000446906
Ensembl peptide - ENSP00000478728
Ensembl peptide - ENSP00000328843
Ensembl peptide - ENSP00000333275
Ensembl peptide - ENSP00000376813
Ensembl peptide - ENSP00000446817
NCBI entrez gene - 7181     See in Manteia.
OMIM - 601529
RefSeq - XM_011538717
RefSeq - NM_001032287
RefSeq - NM_001127362
RefSeq - NM_003297
RefSeq - XM_005269133
RefSeq - XM_006719584
RefSeq - XM_006719585
RefSeq - XM_011538716
RefSeq Peptide - NP_001027458
RefSeq Peptide - NP_003288
RefSeq Peptide - NP_001120834
swissprot - H0YIV1
swissprot - H9NIM2
swissprot - H9NIM3
swissprot - A0A087WUK4
swissprot - P13056
swissprot - F8W1Q1
swissprot - H0YHC6
Ensembl - ENSG00000120798
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr2c1ENSDARG00000045527Danio rerio
 NR2C1ENSGALG00000011327Gallus gallus
 Nr2c1ENSMUSG00000005897Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR2C2 / P49116 / nuclear receptor subfamily 2 group C member 2ENSG0000017746362
NR2F2 / P24468 / nuclear receptor subfamily 2 group F member 2ENSG0000018555124
NR2F1 / P10589 / nuclear receptor subfamily 2 group F member 1ENSG0000017574524
RXRG / P48443 / retinoid X receptor gammaENSG0000014317123
RXRA / P19793 / retinoid X receptor alphaENSG0000018635023
RXRB / P28702 / retinoid X receptor betaENSG0000020423123
NR2F6 / P10588 / nuclear receptor subfamily 2 group F member 6ENSG0000016011322
NR2E1 / Q9Y466 / nuclear receptor subfamily 2 group E member 1ENSG0000011233321
NR2E3 / Q9Y5X4 / nuclear receptor subfamily 2 group E member 3ENSG0000027857020
HNF4A / P41235 / hepatocyte nuclear factor 4 alphaENSG0000010107620
HNF4G / Q14541 / hepatocyte nuclear factor 4 gammaENSG0000016474919


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048386 positive regulation of retinoic acid receptor signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction






 

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