ENSMUSG00000005897


Mus musculus

Features
Gene ID: ENSMUSG00000005897
  
Biological name :Nr2c1
  
Synonyms : Nr2c1 / Nuclear receptor subfamily 2 group C member 1 / Q505F1
  
Possible biological names infered from orthology : P13056
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C2
Gene start: 94148023
Gene end: 94197211
  
Corresponding Affymetrix probe sets: 10365870 (MoGene1.0st)   1418605_at (Mouse Genome 430 2.0 Array)   1439490_at (Mouse Genome 430 2.0 Array)   1446194_at (Mouse Genome 430 2.0 Array)   1449157_at (Mouse Genome 430 2.0 Array)   1458338_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089858
Ensembl peptide - ENSMUSP00000096945
Ensembl peptide - ENSMUSP00000100927
NCBI entrez gene - 22025     See in Manteia.
MGI - MGI:1352465
RefSeq - NM_011629
RefSeq - XM_006513592
RefSeq Peptide - NP_035759
swissprot - Q505F1
Ensembl - ENSMUSG00000005897
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr2c1ENSDARG00000045527Danio rerio
 NR2C1ENSGALG00000011327Gallus gallus
 NR2C1ENSG00000120798Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr2c2 / P49117 / nuclear receptor subfamily 2, group C, member 2 / P49116*ENSMUSG0000000589362
Rxra / P28700 / retinoid X receptor alpha / P19793*ENSMUSG0000001584624
Nr2f1 / nuclear receptor subfamily 2, group F, member 1 / P10589*ENSMUSG0000006917124
Nr2f2 / P43135 / nuclear receptor subfamily 2, group F, member 2 / P24468*ENSMUSG0000003055124
Rxrg / P28705 / Retinoic acid receptor RXR-gamma / P48443* / retinoid X receptor gamma*ENSMUSG0000001584323
Rxrb / P28704 / retinoid X receptor beta / P28702*ENSMUSG0000003965623
Nr2e1 / Q64104 / nuclear receptor subfamily 2, group E, member 1 / Q9Y466*ENSMUSG0000001980322
Nr2f6 / P43136 / Nuclear receptor subfamily 2 group F member 6 / P10588*ENSMUSG0000000239322
Nr2e3 / Q9QXZ7 / Photoreceptor-specific nuclear receptor / Q9Y5X4* / nuclear receptor subfamily 2 group E member 3*ENSMUSG0000003229221
Hnf4a / P49698 / Hepatocyte nuclear factor 4-alpha / P41235*ENSMUSG0000001795020
Hnf4g / hepatocyte nuclear factor 4 gamma / Q14541*ENSMUSG0000001768819


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048386 positive regulation of retinoic acid receptor signaling pathway IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001588 hemoglobin abnormalities "defects in the levels or the function of the oxygen-carrying protein of erythrocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr