ENSMUSG00000069171


Mus musculus

Features
Gene ID: ENSMUSG00000069171
  
Biological name :Nr2f1
  
Synonyms : Nr2f1 / nuclear receptor subfamily 2, group F, member 1
  
Possible biological names infered from orthology : P10589
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C1
Gene start: 78188973
Gene end: 78199757
  
Corresponding Affymetrix probe sets: 10410766 (MoGene1.0st)   1418157_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133704
Ensembl peptide - ENSMUSP00000153321
Ensembl peptide - ENSMUSP00000089036
Ensembl peptide - ENSMUSP00000118161
Ensembl peptide - ENSMUSP00000122618
NCBI entrez gene - 13865     See in Manteia.
MGI - MGI:1352451
RefSeq - XM_017315378
RefSeq - XM_006517086
RefSeq - XM_006517085
RefSeq - NM_010151
RefSeq - XM_017315379
RefSeq Peptide - NP_034281
RefSeq Peptide - NP_001334467
RefSeq Peptide - NP_001334468
swissprot - Q32NY6
swissprot - B8JJI9
swissprot - A0A286YD96
swissprot - F7CII1
Ensembl - ENSMUSG00000069171
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr2f1aENSDARG00000052695Danio rerio
 NR2F1ENSGALG00000027907Gallus gallus
 NR2F1ENSG00000175745Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr2f2 / P43135 / nuclear receptor subfamily 2, group F, member 2 / P24468*ENSMUSG0000003055187
Nr2f6 / P43136 / Nuclear receptor subfamily 2 group F member 6 / P10588*ENSMUSG0000000239360
Rxra / P28700 / retinoid X receptor alpha / P19793*ENSMUSG0000001584638
Nr2c2 / P49117 / nuclear receptor subfamily 2, group C, member 2 / P49116*ENSMUSG0000000589337
Rxrg / P28705 / Retinoic acid receptor RXR-gamma / P48443* / retinoid X receptor gamma*ENSMUSG0000001584336
Nr2e3 / Q9QXZ7 / Photoreceptor-specific nuclear receptor / Q9Y5X4* / nuclear receptor subfamily 2 group E member 3*ENSMUSG0000003229235
Rxrb / P28704 / retinoid X receptor beta / P28702*ENSMUSG0000003965635
Nr2e1 / Q64104 / nuclear receptor subfamily 2, group E, member 1 / Q9Y466*ENSMUSG0000001980333
Nr2c1 / Q505F1 / Nuclear receptor subfamily 2 group C member 1 / P13056*ENSMUSG0000000589733
Hnf4a / P49698 / Hepatocyte nuclear factor 4-alpha / P41235*ENSMUSG0000001795031
Hnf4g / hepatocyte nuclear factor 4 gamma / Q14541*ENSMUSG0000001768829


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003068  Transcription factor COUP
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044323 retinoic acid-responsive element binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Nr2f1tm1Mist/Nr2f1tm1Mist
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Nr2f1tm2.1Mist/Nr2f1tm2.1Mist,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000860 abnormal primary somatosensory cortex morphology "any malformation or absence of the area of the postcentral gyrus and central sulcus that is involved in somatic sensation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nr2f1tm2.1Mist/Nr2f1tm2.1Mist,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000862 absent barrels in primary somatosensory cortex "missing pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:64064]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0001096 abnormal glossopharyngeal ganglion morphology "malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001437 no swallowing reflex "inability to pull food through the esophagus to the stomach in response to feeding" [J:56847]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cluap1tm1.2Hmd/Cluap1tm1.2Hmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm2Rak/Apctm2Rak,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Nr2f1tm1Mist/Nr2f1tm1Mist
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nr2f1tm1Mist/Nr2f1tm1Mist
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003308 abnormal cochlear sensory epithelium 
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0003989 abnormal barrel cortex morphology "malformation of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nr2f1tm2.1Mist/Nr2f1tm2.1Mist,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004167 abnormal cingulate gyrus morphology "any malformation or absence of the ridge in the cerebral cortex located dorsal to the corpus callosum that controls autonomic functions regulating heart rate and blood pressure as well as cognitive and attentional processing" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr2f1tm1Mist/Nr2f1tm1Mist
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004268 abnormal optic stalk morphology "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0004407 increased cochlear hair cell number "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0004589 abnormal cochlear hair cell development "atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0004840 increased Dieters cell number "increased number of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005262 coloboma "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Nr2f1tm2.1Mjts/Nr2f1+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr2f1tm1Mist/Nr2f1tm1Mist
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008221 abnormal hippocampal commissure morphology "any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nr2f1tm1Mist/Nr2f1tm1Mist
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nr2f1tm1Mist/Nr2f1tm1Mist
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008304 abnormal supporting cell differentiation "atypical production of or inability to produce the highly differentiated epithelial cells with distinctive morphological features that surround the hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0008307 short scala media "reduced length of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Nr2f1tm1Mist/Nr2f1tm1Mist
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011389 absent optic disc "absence of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0012535 abnormal optic fissure closure "failure to initiate and/or complete closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk; failure or late closure of the optic fissure prevents the establishment of normal fetal intraocular pressure and can result in microphthalmia associataed with colobomas" [MGI:anna]
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Allelic Composition: Nr2f1tm2.1Mjts/Nr2f1+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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